Cognitive trajectories preluding the onset of different dementia entities: a descriptive longitudinal study using the NACC database.
Humans
Aged
Male
Female
Longitudinal Studies
Cognition
/ physiology
Dementia
/ epidemiology
Neuropsychological Tests
Middle Aged
Alzheimer Disease
/ psychology
Aged, 80 and over
Disease Progression
Databases, Factual
Frontotemporal Dementia
/ psychology
Lewy Body Disease
/ psychology
Dementia, Vascular
/ psychology
Memory, Episodic
Cognitive Dysfunction
/ diagnosis
Executive Function
/ physiology
Alzheimer’s disease
Frontotemporal Lobal degeneration
Lewy body dementia
Vascular dementia
Journal
Aging clinical and experimental research
ISSN: 1720-8319
Titre abrégé: Aging Clin Exp Res
Pays: Germany
ID NLM: 101132995
Informations de publication
Date de publication:
23 May 2024
23 May 2024
Historique:
received:
17
02
2024
accepted:
02
05
2024
medline:
23
5
2024
pubmed:
23
5
2024
entrez:
23
5
2024
Statut:
epublish
Résumé
To describe the 10-year preclinical cognitive trajectories of older, non-demented individuals towards the onset of the four most prevalent types of dementia, i.e., Alzheimer's disease(AD), Lewy body(LBD), vascular(VD) and frontotemporal dementia(FTD). Our analysis focused on data from older (≥ 60years) NACC (National Alzheimer's Coordinating Center) participants. Four distinct presymptomatic dementia groups (AD-LBD-VD-FTD) and a comparison group of cognitively unimpaired(CU) participants were formed. Comprehensive cognitive assessments involving verbal episodic memory, semantic verbal fluency, confrontation naming, mental processing speed - attention and executive function - cognitive flexibility were conducted at baseline and on an approximately yearly basis. Descriptive analyses (adjusted general linear models) were performed to determine and compare the yearly cognitive scores of each group throughout the follow-up. Exploratory analyses were conducted to estimate the rates of cognitive decline. There were 3343 participants who developed AD, 247 LBD, 108 FTD, 155 VD and 3398 composed the CU group. Participants with AD performed worse on episodic memory than those with VD and LBD for about 3 to 4 years prior to dementia onset (the FTD group documented an intermediate course). Presymptomatic verbal fluency and confrontation naming trajectories differentiated quite well between the FTD group and the remaining dementia entities. Participants with incident LBD and VD performed worse than those with AD on executive functions and mental processing speed-attention since about 5 years prior to the onset of dementia, and worse than those with FTD more proximally to the diagnosis of the disorder. Heterogeneous cognitive trajectories characterize the presymptomatic courses of the most prevalent dementia entities.
Identifiants
pubmed: 38780681
doi: 10.1007/s40520-024-02769-9
pii: 10.1007/s40520-024-02769-9
doi:
Types de publication
Journal Article
Langues
eng
Sous-ensembles de citation
IM
Pagination
119Informations de copyright
© 2024. The Author(s).
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