Interleukin-1β Polymorphisms Are Genetic Markers of Susceptibility to Periprosthetic Joint Infection in Total Hip and Knee Arthroplasty.
Humans
Arthroplasty, Replacement, Knee
/ adverse effects
Prosthesis-Related Infections
/ genetics
Arthroplasty, Replacement, Hip
/ adverse effects
Male
Female
Polymorphism, Single Nucleotide
Interleukin-1beta
/ genetics
Aged
C-Reactive Protein
/ genetics
Middle Aged
Genetic Predisposition to Disease
Case-Control Studies
Serum Amyloid P-Component
/ genetics
Genetic Markers
PTX3
association analysis
biomarker
epistasis
haplotype
periprosthetic infection
single-nucleotide polymorphism
Journal
Genes
ISSN: 2073-4425
Titre abrégé: Genes (Basel)
Pays: Switzerland
ID NLM: 101551097
Informations de publication
Date de publication:
08 May 2024
08 May 2024
Historique:
received:
15
04
2024
revised:
02
05
2024
accepted:
05
05
2024
medline:
25
5
2024
pubmed:
25
5
2024
entrez:
25
5
2024
Statut:
epublish
Résumé
Periprosthetic joint infections (PJIs) are serious complications of prosthetic surgery. The criteria for the diagnosis of PJI integrate clinical and laboratory findings in a complex and sometimes inconclusive workflow. Host immune factors hold potential as diagnostic biomarkers in bone and joint infections. We reported that the humoral pattern-recognition molecule long pentraxin 3 (PTX3) predicts PJI in total hip and knee arthroplasty (THA and TKA, respectively). If and how genetic variation in
Identifiants
pubmed: 38790226
pii: genes15050596
doi: 10.3390/genes15050596
pii:
doi:
Substances chimiques
Interleukin-1beta
0
C-Reactive Protein
9007-41-4
PTX3 protein
148591-49-5
Serum Amyloid P-Component
0
IL1B protein, human
0
Genetic Markers
0
Types de publication
Journal Article
Langues
eng
Sous-ensembles de citation
IM
Subventions
Organisme : Fondazione Beppe e Nuccy Angiolini ONLUS
ID : na