Longitudinal alcohol-related brain changes in older adults: The Sydney Memory and Ageing Study.
Humans
Male
Aged
Female
Longitudinal Studies
Brain
/ diagnostic imaging
White Matter
/ diagnostic imaging
Aged, 80 and over
Magnetic Resonance Imaging
Gray Matter
/ pathology
Alcohol Drinking
Atrophy
/ pathology
Aging
/ pathology
Binge Drinking
/ pathology
Thalamus
/ diagnostic imaging
Hippocampus
/ diagnostic imaging
Amygdala
/ diagnostic imaging
Corpus Callosum
/ diagnostic imaging
ageing
alcohol use
epidemiology
longitudinal neuroimaging
neurodegeneration
Journal
Addiction biology
ISSN: 1369-1600
Titre abrégé: Addict Biol
Pays: United States
ID NLM: 9604935
Informations de publication
Date de publication:
May 2024
May 2024
Historique:
revised:
25
03
2024
received:
09
11
2023
accepted:
22
04
2024
medline:
27
5
2024
pubmed:
27
5
2024
entrez:
26
5
2024
Statut:
ppublish
Résumé
Increases in harmful drinking among older adults indicate the need for a more thorough understanding of the relationship between later-life alcohol use and brain health. The current study investigated the relationships between alcohol use and progressive grey and white matter changes in older adults using longitudinal data. A total of 530 participants (aged 70 to 90 years; 46.0% male) were included. Brain outcomes assessed over 6 years included total grey and white matter volume, as well as volume of the hippocampus, thalamus, amygdala, corpus callosum, orbitofrontal cortex and insula. White matter integrity was also investigated. Average alcohol use across the study period was the main exposure of interest. Past-year binge drinking and reduction in drinking from pre-baseline were additional exposures of interest. Within the context of low-level average drinking (averaging 11.7 g per day), higher average amount of alcohol consumed was associated with less atrophy in the left (B = 7.50, pFDR = 0.010) and right (B = 5.98, pFDR = 0.004) thalamus. Past-year binge-drinking was associated with poorer white matter integrity (B = -0.013, pFDR = 0.024). Consuming alcohol more heavily in the past was associated with greater atrophy in anterior (B = -12.73, pFDR = 0.048) and posterior (B = -17.88, pFDR = 0.004) callosal volumes over time. Across alcohol exposures and neuroimaging markers, no other relationships were statistically significant. Within the context of low-level drinking, very few relationships between alcohol use and brain macrostructure were identified. Meanwhile, heavier drinking was negatively associated with white matter integrity.
Types de publication
Journal Article
Langues
eng
Sous-ensembles de citation
IM
Pagination
e13402Subventions
Organisme : NIH HHS
ID : R01AA030575
Pays : United States
Organisme : National Health and Medical Research Council
ID : ID350833
Organisme : National Health and Medical Research Council
ID : ID568969
Organisme : National Health and Medical Research Council
ID : APP1093083
Informations de copyright
© 2024 The Author(s). Addiction Biology published by John Wiley & Sons Ltd on behalf of Society for the Study of Addiction.
Références
Bryazka D, Reitsma MB, Griswold MG, et al. Population‐level risks of alcohol consumption by amount, geography, age, sex, and year: a systematic analysis for the Global Burden of Disease Study 2020. Lancet. 2022;400(10347):185‐235. doi:10.1016/S0140‐6736(22)00847‐9
Schwarzinger M, Pollock BG, Hasan OSM, et al. Contribution of alcohol use disorders to the burden of dementia in France 2008–13: a nationwide retrospective cohort study. Lancet Public Health. 2018;3(3):e124‐e132. doi:10.1016/S2468‐2667(18)30022‐7
Livingston G, Huntley J, Sommerlad A, et al. Dementia prevention, intervention, and care: 2020 report of the Lancet Commission. The Lancet. 2020;396(10248):413‐446. doi:10.1016/S0140‐6736(20)30367‐6
Han BH, Moore AA, Ferris R, Palamar JJ. Binge drinking among older adults in the United States, 2015 to 2017. J Am Geriatr Soc. 2019;67(10):2139‐2144. doi:10.1111/jgs.16071
Grucza RA, Sher KJ, Kerr WC, et al. Trends in adult alcohol use and binge drinking in the early 21st‐century United States: a meta‐analysis of 6 National Survey Series. Alcohol Clin Exp Res. 2018;42(10):1939‐1950. doi:10.1111/acer.13859
de Bruin EA, Hulshoff Pol HE, Bijl S, et al. Associations between alcohol intake and brain volumes in male and female moderate drinkers. Alcohol Clin Exp Res. 2005;29(4):656‐663. doi:10.1097/01.ALC.0000159110.17351.C0
McEvoy LK, Fennema‐Notestine C, Elman JA, et al. Alcohol intake and brain white matter in middle aged men: microscopic and macroscopic differences. NeuroImage Clin. 2018;18:390‐398. doi:10.1016/j.nicl.2018.02.006
Topiwala A, Allan CL, Valkanova V, et al. Moderate alcohol consumption as risk factor for adverse brain outcomes and cognitive decline: longitudinal cohort study. BMJ. 2017;357. doi:10.1136/bmj.j2353
Topiwala A, Ebmeier KP, Maullin‐Sapey T, Nichols TE. Alcohol consumption and MRI markers of brain structure and function: cohort study of 25,378 UK Biobank participants. NeuroImage Clin. 2022;35:103066. doi:10.1016/j.nicl.2022.103066
Daviet R, Aydogan G, Jagannathan K, et al. Associations between alcohol consumption and gray and white matter volumes in the UK Biobank. Nat Commun. 2022;13(1):1175. doi:10.1038/s41467‐022‐28735‐5
Evangelou E, Suzuki H, Bai W, et al. Alcohol consumption in the general population is associated with structural changes in multiple organ systems. Elife. 2021;10:e65325. doi:10.7554/eLife.65325
Immonen S, Launes J, Järvinen I, et al. Moderate alcohol use is associated with decreased brain volume in early middle age in both sexes. Sci Rep. 2020;10(1):13998. doi:10.1038/s41598‐020‐70910‐5
Gu Y, Scarmeas N, Short EE, et al. Alcohol intake and brain structure in a multiethnic elderly cohort. Clin Nutr. 2014;33(4):662‐667. doi:10.1016/j.clnu.2013.08.004
Anstey KJ, Jorm AF, Réglade‐Meslin C, et al. Weekly alcohol consumption, brain atrophy, and white matter hyperintensities in a community‐based sample aged 60 to 64 years. Psychosom Med. 2006;68(5):778‐785. doi:10.1097/01.psy.0000237779.56500.af
Sachdev PS, Chen X, Wen W, Anstry KJ. Light to moderate alcohol use is associated with increased cortical gray matter in middle‐aged men: a voxel‐based morphometric study. Psychiatry Res Neuroimaging. 2008;163(1):61‐69. doi:10.1016/j.pscychresns.2007.08.009
den Heijer T, Vermeer SE, van Dijk EJ, et al. Alcohol intake in relation to brain magnetic resonance imaging findings in older persons without dementia. Am J Clin Nutr. 2004;80(4):992‐997. doi:10.1093/ajcn/80.4.992
Koch M, Costanzo S, Fitzpatrick AL, et al. Alcohol consumption, brain amyloid‐β deposition, and brain structural integrity among older adults free of dementia. J Alzheimers Dis. 2020;74(2):509‐519. doi:10.3233/JAD‐190834
Mukamal KJ, Longstreth WT Jr, Mittleman MA, Crum RM, Siscovick DS. Alcohol consumption and subclinical findings on magnetic resonance imaging of the brain in older adults: the cardiovascular health study. Stroke. 2001;32(9):1939‐1946. doi:10.1161/hs0901.095723
Kapogiannis D, Kisser J, Davatzikos C, Ferrucci L, Metter J, Resnick SM. Alcohol consumption and premotor corpus callosum in older adults. Eur Neuropsychopharmacol. 2012;22(10):704‐710. doi:10.1016/j.euroneuro.2012.02.003
Sachdev PS, Brodaty H, Reppermund S, et al. The Sydney Memory and Ageing Study (MAS): methodology and baseline medical and neuropsychiatric characteristics of an elderly epidemiological non‐demented cohort of Australians aged 70–90 years. Int Psychogeriatr. 2010;22(8):1248‐1264. doi:10.1017/S1041610210001067
Topiwala A, Ebmeier KP. Effects of drinking on late‐life brain and cognition. BMJ Ment Health. 2018;21(1):12‐15. doi:10.1136/eb‐2017‐102820
Du J, Koch FC, Xia A, et al. Difference in distribution functions: A new diffusion weighted imaging metric for estimating white matter integrity. Neuroimage. 2021;240:118381. doi:10.1016/j.neuroimage.2021.118381
Baykara E, Gesierich B, Adam R, et al. A novel imaging marker for small vessel disease based on skeletonization of white matter tracts and diffusion histograms. Ann Neurol. 2016;80(4):581‐592. doi:10.1002/ana.24758
World Health Organization, Babor TF, Higgins‐Biddle JC, Saunders JB, Monteiro MG. AUDIT: The Alcohol Use Disorders Identification Test: Guidelines for Use in Primary Health Care [Internet]. World Health Organization; 2001 [cited 2023 Mar 22]. Report No.: WHO/MSD/MSB/01.6a. Available from: https://apps.who.int/iris/handle/10665/67205
Mewton L, Visontay R, Hoy N, et al. The relationship between alcohol use and dementia in adults aged more than 60 years: a combined analysis of prospective, individual‐participant data from 15 international studies. Addiction. 2023;118(3):412‐424. doi:10.1111/add.16035
Wood SN. Generalized Additive Models: An Introduction with R. Second ed. CRC Press; 2017. 497 p. doi:10.1201/9781315370279
Wood S, Wood MS. Package ‘mgcv.’ R Package Version 2015;1(29):729.
Bates D, Mächler M, Bolker B, Walker S. Fitting linear mixed‐effects models using lme4. ArXiv Prepr ArXiv14065823. 2014.
Kievit RA, Brandmaier AM, Ziegler G, et al. Developmental cognitive neuroscience using latent change score models: A tutorial and applications. Dev Cogn Neurosci. 2018;33:99‐117. doi:10.1016/j.dcn.2017.11.007
Del Boca FK, Darkes J. The validity of self‐reports of alcohol consumption: state of the science and challenges for research. Addict Abingdon Engl. 2003;98(Suppl 2):1‐12. doi:10.1046/j.1359‐6357.2003.00586.x
Visontay R, Rao RT, Mewton L. Alcohol use and dementia: new research directions. Curr Opin Psychiatry. 2021;34(2):165‐170. doi:10.1097/YCO.0000000000000679
Sullivan EV, Pfefferbaum A. Alcohol use disorder: neuroimaging evidence for accelerated aging of brain morphology and hypothesized contribution to age‐related dementia. Alcohol. 2023;107:44‐55.
Sullivan EV, Pfefferbaum A. Brain‐behavior relations and effects of aging and common comorbidities in alcohol use disorder: A review. Neuropsychology. 2019;33(6):760‐780. doi:10.1037/neu0000557
Sabia S, Fayosse A, Dumurgier J, et al. Alcohol consumption and risk of dementia: 23 year follow‐up of Whitehall II cohort study. BMJ. 2018;362.
Kim JW, Byun MS, Yi D, et al. Association of moderate alcohol intake with in vivo amyloid‐beta deposition in human brain: A cross‐sectional study. PLoS Med. 2020;17(2):e1003022. doi:10.1371/journal.pmed.1003022
Lundgaard I, Wang W, Eberhardt A, et al. Beneficial effects of low alcohol exposure, but adverse effects of high alcohol intake on glymphatic function. Sci Rep. 2018;8(1):2246. doi:10.1038/s41598‐018‐20424‐y
Topiwala A, Wang C, Ebmeier KP, et al. Associations between moderate alcohol consumption, brain iron, and cognition in UK Biobank participants: observational and mendelian randomization analyses. PLoS Med. 2022;19(7):e1004039. doi:10.1371/journal.pmed.1004039
Pfefferbaum A, Adalsteinsson E, Sullivan EV. Dysmorphology and microstructural degradation of the corpus callosum: interaction of age and alcoholism. Neurobiol Aging. 2006;27(7):994‐1009. doi:10.1016/j.neurobiolaging.2005.05.007
Fortier CB, Leritz EC, Salat DH, et al. Widespread effects of alcohol on white matter microstructure. Alcohol Clin Exp Res. 2014;38(12):2925‐2933. doi:10.1111/acer.12568
Spindler C, Mallien L, Trautmann S, Alexander N, Muehlhan M. A coordinate‐based meta‐analysis of white matter alterations in patients with alcohol use disorder. Transl Psychiatry. 2022;12(1):40. doi:10.1038/s41398‐022‐01809‐0
Pfefferbaum A, Rosenbloom MJ, Chu W, et al. White matter microstructural recovery with abstinence and decline with relapse in alcohol dependence interacts with normal ageing: a controlled longitudinal DTI study. Lancet Psychiatry. 2014;1(3):202‐212. doi:10.1016/S2215‐0366(14)70301‐3
Agunbiade K, Fonville L, McGonigle J, et al. Alterations in white matter microstructure in alcohol and alcohol‐polydrug dependence: associations with lifetime alcohol and nicotine exposure. Addict Biol. 2022;27(5):e13207. doi:10.1111/adb.13207
Pfefferbaum A, Sullivan EV. Microstructural but not macrostructural disruption of white matter in women with chronic alcoholism. Neuroimage. 2002;15(3):708‐718. doi:10.1006/nimg.2001.1018
Zhao Q, Sullivan EV, Honnorat N, et al. Association of heavy drinking with deviant fiber tract development in frontal brain systems in adolescents. JAMA Psychiatry. 2021;78(4):407‐415. doi:10.1001/jamapsychiatry.2020.4064
Heffernan M, Mather KA, Xu J, et al. Alcohol consumption and incident dementia: evidence from the Sydney Memory and Ageing Study. J Alzheimers Dis. 2016;52(2):529‐538. doi:10.3233/JAD‐150537