Effect of

Humans Leukemia, Myeloid, Acute / genetics DNA Methyltransferase 3A / genetics Promoter Regions, Genetic / genetics DEAD-box RNA Helicases / genetics DNA Methylation / genetics Male DNA (Cytosine-5-)-Methyltransferases / genetics Female Middle Aged Adult Mutation / genetics Aged Case-Control Studies Neoplasm Proteins

Journal

BioMed research international
ISSN: 2314-6141
Titre abrégé: Biomed Res Int
Pays: United States
ID NLM: 101600173

Informations de publication

Date de publication:
2024
Historique:
received: 16 02 2024
revised: 21 04 2024
accepted: 06 05 2024
medline: 29 5 2024
pubmed: 29 5 2024
entrez: 29 5 2024
Statut: epublish

Résumé

Epigenetic alterations have been observed in many hematological malignancies, including acute myeloid leukemia (AML). Many of these alterations result from mutations in DNA methyl transferase (DNMT) enzymes, disabling them to methylate target genes in a proper way. In this case-control study, we investigated the association between R882H mutation in

Identifiants

DOI: 10.1155/2024/9625043 PMID: 38807916 PMC: PMC11132831
pubmed: 38807916
doi: 10.1155/2024/9625043
pmc: PMC11132831
doi:

Substances chimiques

DNA Methyltransferase 3A EC 2.1.1.37
DNMT3A protein, human 0
DEAD-box RNA Helicases EC 3.6.4.13
DNA (Cytosine-5-)-Methyltransferases EC 2.1.1.37
DDX43 protein, human EC 3.6.1.-
Neoplasm Proteins 0

Types de publication

Journal Article

Langues

eng

Sous-ensembles de citation

IM

Pagination

9625043

Informations de copyright

Copyright © 2024 Tahere Tabatabaei et al.

Déclaration de conflit d'intérêts

The authors declare that they have no conflict of interest.

Auteurs

Tahere Tabatabaei (T)

Department of Hematology and Blood Transfusion, School of Allied Medical Sciences, Iran University of Medical Sciences, Tehran, Iran.
ORCID: 0000-0003-4061-6988

Mohammad Reza Rezvany (MR)

Department of Hematology and Blood Transfusion, School of Allied Medical Sciences, Iran University of Medical Sciences, Tehran, Iran.
ORCID: 0000-0003-0323-7671

Bahare Ghasemi (B)

Department of Hematology and Blood Transfusion, School of Allied Medical Sciences, Iran University of Medical Sciences, Tehran, Iran.
ORCID: 0000-0002-8149-9653

Farzane Vafaei (F)

Blood Transfusion Research Center, High Institute for Research and Education in Transfusion Medicine, Isfahan, Iran.
ORCID: 0009-0006-7867-9828

Masoumeh Kiani Zadeh (MK)

Blood Transfusion Research Center, High Institute for Research and Education in Transfusion Medicine, Tehran, Iran.
ORCID: 0009-0006-8073-6588

Farhad Zaker (F)

Department of Hematology and Blood Transfusion, School of Allied Medical Sciences, Iran University of Medical Sciences, Tehran, Iran.
ORCID: 0000-0002-5562-8992

Arash Salmaninejad (A)

Regenerative Medicine, Organ Procurement and Transplantation Multi-Disciplinary Center, Razi Hospital, School of Medicine, Guilan University of Medical Sciences, Rasht, Iran.
Department of Medical Genetics, Faculty of Medicine, Tehran University of Medical Sciences, Tehran, Iran.
ORCID: 0000-0001-6141-3915

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Classifications MeSH

questionsmedicales.fr › Eucaryotes › Animaux › Chordés › Vertébrés › Mammifères › Eutheria › Primates › Haplorhini › Catarrhini › Hominidae › Humains › Effect of
questionsmedicales.fr › Tumeurs › Tumeurs par type histologique › Leucémies › Leucémie myéloïde › Leucémie aigüe myéloïde › Effect of
questionsmedicales.fr › Enzymes et coenzymes › Enzymes › Transferases › One-carbon group transferases › Methyltransferases › DNA modification methylases › DNA-Cytosine Methylases › DNA (cytosine-5-)-methyltransferase › DNA methyltransferase 3A › Effect of
questionsmedicales.fr › Phénomènes génétiques › Structures génétiques › Génome › Composants de génome › Gènes › Composants de gène › Éléments de régulation transcriptionnelle › Régions promotrices (génétique) › Effect of
questionsmedicales.fr › Enzymes et coenzymes › Enzymes › Transferases › Phosphotransferases › Nucleotidyltransferases › RNA nucleotidyltransferases › RNA helicases › DEAD-box RNA helicases › Effect of
questionsmedicales.fr › Phénomènes génétiques › Méthylation de l'ADN › Effect of
questionsmedicales.fr › Enzymes et coenzymes › Enzymes › Transferases › One-carbon group transferases › Methyltransferases › DNA modification methylases › DNA-Cytosine Methylases › DNA (cytosine-5-)-methyltransferase › Effect of
questionsmedicales.fr › Personnes › Tranches d'âge › Adulte › Adulte d'âge moyen › Effect of
questionsmedicales.fr › Personnes › Tranches d'âge › Adulte › Effect of
questionsmedicales.fr › Phénomènes génétiques › Variation génétique › Mutation › Effect of
questionsmedicales.fr › Personnes › Tranches d'âge › Adulte › Sujet âgé › Effect of
questionsmedicales.fr › Environnement et santé publique › Santé publique › Méthodes épidémiologiques › Caractéristiques des études épidémiologiques › Études épidémiologiques › Études cas-témoins › Effect of
questionsmedicales.fr › Acides aminés, peptides et protéines › Protéines › Protéines tumorales › Effect of