OTULIN haploinsufficiency predisposes to environmentally directed inflammation.

Animals Haploinsufficiency Mice Inflammation / genetics Lipopolysaccharides Macrophages / immunology Disease Models, Animal Cytokines / metabolism Poly I-C Mice, Inbred C57BL Mice, Knockout Humans
OTULIN OTULIN deficiency OTULIN-related autoinflammatory syndrome inborn errors in immunity inflammation

Journal

Frontiers in immunology
ISSN: 1664-3224
Titre abrégé: Front Immunol
Pays: Switzerland
ID NLM: 101560960

Informations de publication

Date de publication:
2024
Historique:
received: 01 07 2022
accepted: 29 03 2024
medline: 3 6 2024
pubmed: 3 6 2024
entrez: 3 6 2024
Statut: epublish

Résumé

Recently, OTULIN haploinsufficiency was linked to enhanced susceptibility to

Identifiants

DOI: 10.3389/fimmu.2024.983686 PMID: 38827742 PMC: PMC11140568
pubmed: 38827742
doi: 10.3389/fimmu.2024.983686
pmc: PMC11140568
doi:

Substances chimiques

Lipopolysaccharides 0
Cytokines 0
Poly I-C O84C90HH2L

Types de publication

Journal Article

Langues

eng

Sous-ensembles de citation

IM

Pagination

983686

Informations de copyright

Copyright © 2024 Staels, Bücken, De Vuyst, Willemsen, Van Nieuwenhove, Gerbaux, Neumann, Malviya, Van Meerbeeck, Haughton, Seldeslachts, Gouwy, Martinod, Vande Velde, Proost, Yshii, Schlenner, Schrijvers, Liston and Humblet-Baron.

Déclaration de conflit d'intérêts

The authors declare that the research was conducted in the absence of any commercial or financial relationships that could be construed as a potential conflict of interest.

Auteurs

Frederik Staels (F)

Department of Microbiology, Immunology and Transplantation, Laboratory of Adaptive Immunology, KU Leuven, Leuven, Belgium.
Department of Microbiology, Immunology and Transplantation, Allergy and Clinical Immunology Research Group, KU Leuven, Leuven, Belgium.

Leoni Bücken (L)

Department of Microbiology, Immunology and Transplantation, Laboratory of Adaptive Immunology, KU Leuven, Leuven, Belgium.

Leana De Vuyst (L)

Department of Microbiology, Immunology and Transplantation, Laboratory of Adaptive Immunology, KU Leuven, Leuven, Belgium.

Mathijs Willemsen (M)

Department of Microbiology, Immunology and Transplantation, Laboratory of Adaptive Immunology, KU Leuven, Leuven, Belgium.

Erika Van Nieuwenhove (E)

Department of Microbiology, Immunology and Transplantation, Laboratory of Adaptive Immunology, KU Leuven, Leuven, Belgium.

Margaux Gerbaux (M)

Department of Microbiology, Immunology and Transplantation, Laboratory of Adaptive Immunology, KU Leuven, Leuven, Belgium.

Julika Neumann (J)

Department of Microbiology, Immunology and Transplantation, Laboratory of Adaptive Immunology, KU Leuven, Leuven, Belgium.
VIB-KU Leuven Center for Brain and Disease Research, Leuven, Belgium.

Vanshika Malviya (V)

Department of Microbiology, Immunology and Transplantation, Laboratory of Adaptive Immunology, KU Leuven, Leuven, Belgium.

Lize Van Meerbeeck (L)

Department of Microbiology, Immunology and Transplantation, Laboratory of Adaptive Immunology, KU Leuven, Leuven, Belgium.

Jeason Haughton (J)

Department of Microbiology, Immunology and Transplantation, Laboratory of Adaptive Immunology, KU Leuven, Leuven, Belgium.

Laura Seldeslachts (L)

Department of Imaging and Pathology, Biomedical MRI, KU Leuven, Leuven, Belgium.

Mieke Gouwy (M)

Department of Microbiology, Immunology and Transplantation, Molecular Immunology, KU Leuven, Leuven, Belgium.

Kimberly Martinod (K)

Department of Microbiology, Immunology and Transplantation, Molecular and Vascular Biology, KU Leuven, Leuven, Belgium.

Greetje Vande Velde (G)

Department of Imaging and Pathology, Biomedical MRI, KU Leuven, Leuven, Belgium.

Paul Proost (P)

Department of Microbiology, Immunology and Transplantation, Molecular Immunology, KU Leuven, Leuven, Belgium.

Lidia Yshii (L)

Department of Neuroscience, KU Leuven, Leuven, Belgium.

Susan Schlenner (S)

Department of Microbiology, Immunology and Transplantation, Laboratory of Adaptive Immunology, KU Leuven, Leuven, Belgium.

Rik Schrijvers (R)

Department of Microbiology, Immunology and Transplantation, Laboratory of Adaptive Immunology, KU Leuven, Leuven, Belgium.
Department of Microbiology, Immunology and Transplantation, Allergy and Clinical Immunology Research Group, KU Leuven, Leuven, Belgium.
Department of General Internal Medicine, University Hospitals Leuven, Leuven, Belgium.

Adrian Liston (A)

Department of Pathology, University of Cambridge, Cambridge, United Kingdom.

Stephanie Humblet-Baron (S)

Department of Microbiology, Immunology and Transplantation, Laboratory of Adaptive Immunology, KU Leuven, Leuven, Belgium.

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Classifications MeSH

questionsmedicales.fr › Eucaryotes › Animaux › OTULIN haploinsufficiency predisposes to...
questionsmedicales.fr › Phénomènes génétiques › Génotype › Dosage génique › Haploinsuffisance › OTULIN haploinsufficiency predisposes to...
questionsmedicales.fr › Eucaryotes › Animaux › Chordés › Vertébrés › Mammifères › Eutheria › Rodentia › Muridae › Murinae › Souris › OTULIN haploinsufficiency predisposes to...
questionsmedicales.fr › États, signes et symptômes pathologiques › Processus pathologiques › Inflammation › OTULIN haploinsufficiency predisposes to...
questionsmedicales.fr › Facteurs biologiques › Toxines biologiques › Toxines bactériennes › Endotoxines › Lipopolysaccharides › OTULIN haploinsufficiency predisposes to...
questionsmedicales.fr › Systèmes sanguin et immunitaire › Système immunitaire › Phagocytes › Macrophages › OTULIN haploinsufficiency predisposes to...
questionsmedicales.fr › Techniques d'investigation › Modèles théoriques › Modèles biologiques › Modèles animaux de maladie humaine › OTULIN haploinsufficiency predisposes to...
questionsmedicales.fr › Facteurs biologiques › Protéines et peptides de signalisation intercellulaire › Cytokines › OTULIN haploinsufficiency predisposes to...
questionsmedicales.fr › Acides nucléiques, nucléotides et nucléosides › Nucléotides › Polynucléotides › Polyribonucléotides › Poly I › Poly I-C › OTULIN haploinsufficiency predisposes to...
questionsmedicales.fr › Eucaryotes › Animaux › Chordés › Vertébrés › Mammifères › Eutheria › Rodentia › Muridae › Murinae › Souris › Lignées consanguines de souris › Souris de lignée C57BL › OTULIN haploinsufficiency predisposes to...
questionsmedicales.fr › Eucaryotes › Animaux › Chordés › Vertébrés › Mammifères › Eutheria › Rodentia › Muridae › Murinae › Souris › Souris transgéniques › Souris knockout › OTULIN haploinsufficiency predisposes to...
questionsmedicales.fr › Eucaryotes › Animaux › Chordés › Vertébrés › Mammifères › Eutheria › Primates › Haplorhini › Catarrhini › Hominidae › Humains › OTULIN haploinsufficiency predisposes to...