Macrophage-derived macrophage migration inhibitory factor mediates renal injury in anti-glomerular basement membrane glomerulonephritis.
Macrophage Migration-Inhibitory Factors
/ metabolism
Animals
Macrophages
/ immunology
Mice
Anti-Glomerular Basement Membrane Disease
/ immunology
Intramolecular Oxidoreductases
/ metabolism
Histocompatibility Antigens Class II
/ metabolism
Antigens, Differentiation, B-Lymphocyte
/ metabolism
Disease Models, Animal
NF-kappa B
/ metabolism
Mice, Knockout
p38 Mitogen-Activated Protein Kinases
/ metabolism
T-Lymphocytes, Regulatory
/ immunology
Mice, Inbred C57BL
Th17 Cells
/ immunology
Proteinuria
/ immunology
Signal Transduction
MIF
T cells
anti-GBM crescentic glomerulonephritis
inflammation
macrophages
Journal
Frontiers in immunology
ISSN: 1664-3224
Titre abrégé: Front Immunol
Pays: Switzerland
ID NLM: 101560960
Informations de publication
Date de publication:
2024
2024
Historique:
received:
25
12
2023
accepted:
30
04
2024
medline:
7
6
2024
pubmed:
7
6
2024
entrez:
7
6
2024
Statut:
epublish
Résumé
Macrophages are a rich source of macrophage migration inhibitory factor (MIF). It is well established that macrophages and MIF play a pathogenic role in anti-glomerular basement membrane crescentic glomerulonephritis (anti-GBM CGN). However, whether macrophages mediate anti-GBM CGN via MIF-dependent mechanism remains unexplored, which was investigated in this study by specifically deleting MIF from macrophages in MIF
Identifiants
pubmed: 38846956
doi: 10.3389/fimmu.2024.1361343
pmc: PMC11153660
doi:
Substances chimiques
Macrophage Migration-Inhibitory Factors
0
invariant chain
0
Mif protein, mouse
EC 5.3.2.1
Intramolecular Oxidoreductases
EC 5.3.-
Histocompatibility Antigens Class II
0
Antigens, Differentiation, B-Lymphocyte
0
NF-kappa B
0
p38 Mitogen-Activated Protein Kinases
EC 2.7.11.24
Types de publication
Journal Article
Langues
eng
Sous-ensembles de citation
IM
Pagination
1361343Informations de copyright
Copyright © 2024 Yang, Li, Huang, Bucala, Xu and Lan.
Déclaration de conflit d'intérêts
The authors declare that the research was conducted in the absence of any commercial or financial relationships that could be construed as a potential conflict of interest.