Argonaute-independent, Dicer-dependent antiviral defense against RNA viruses.

Ribonuclease III / metabolism RNA Viruses / immunology Argonaute Proteins / metabolism Ascomycota / virology RNA Interference Virus Replication / genetics RNA, Viral / metabolism Fungal Proteins / metabolism RNA, Double-Stranded / metabolism
Argonaute Dicer RNAi chestnut blight fungal virus

Journal

Proceedings of the National Academy of Sciences of the United States of America
ISSN: 1091-6490
Titre abrégé: Proc Natl Acad Sci U S A
Pays: United States
ID NLM: 7505876

Informations de publication

Date de publication:
18 Jun 2024
Historique:
medline: 12 6 2024
pubmed: 12 6 2024
entrez: 12 6 2024
Statut: ppublish

Résumé

Antiviral RNA interference (RNAi) is conserved from yeasts to mammals. Dicer recognizes and cleaves virus-derived double-stranded RNA (dsRNA) and/or structured single-stranded RNA (ssRNA) into small-interfering RNAs, which guide effector Argonaute to homologous viral RNAs for digestion and inhibit virus replication. Thus, Argonaute is believed to be essential for antiviral RNAi. Here, we show Argonaute-independent, Dicer-dependent antiviral defense against dsRNA viruses using

Identifiants

DOI: 10.1073/pnas.2322765121 PMID: 38865263
pubmed: 38865263
doi: 10.1073/pnas.2322765121
doi:

Substances chimiques

Ribonuclease III EC 3.1.26.3
Argonaute Proteins 0
RNA, Viral 0
Fungal Proteins 0
RNA, Double-Stranded 0

Types de publication

Journal Article

Langues

eng

Sous-ensembles de citation

IM

Pagination

e2322765121

Subventions

Organisme : MEXT | Japan Society for the Promotion of Science (JSPS)
ID : 22F22095 21H05035 21K18222 16H06436 16H06429
Organisme : MEXT | Japan Society for the Promotion of Science (JSPS)
ID : 19J00261

Déclaration de conflit d'intérêts

Competing interests statement:The authors declare no competing interest.

Auteurs

Yukiyo Sato (Y)

Institute of Plant Science and Resources, Okayama University, Kurashiki, Okayama 710-0046, Japan.

Hideki Kondo (H)

Institute of Plant Science and Resources, Okayama University, Kurashiki, Okayama 710-0046, Japan.
ORCID: 0000-0001-9220-5350

Nobuhiro Suzuki (N)

Institute of Plant Science and Resources, Okayama University, Kurashiki, Okayama 710-0046, Japan.
ORCID: 0000-0003-0097-9856

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Classifications MeSH

questionsmedicales.fr › Enzymes et coenzymes › Enzymes › Hydrolases › Esterases › Ribonucléases › Endoribonucleases › Ribonuclease III › Argonaute-independent, Dicer-dependent...
questionsmedicales.fr › Virus › Virus à ARN › Argonaute-independent, Dicer-dependent...
questionsmedicales.fr › Acides aminés, peptides et protéines › Protéines › Nucléoprotéines › Protéines de liaison à l'ARN › Ribonucléoprotéines › Complexe réprimant l'expression de l'ARN › Protéines Argonaute › Argonaute-independent, Dicer-dependent...
questionsmedicales.fr › Eucaryotes › Champignons › Ascomycota › Argonaute-independent, Dicer-dependent...
questionsmedicales.fr › Phénomènes génétiques › Régulation de l'expression des gènes › Épigenèse génétique › Extinction de l'expression des gènes › Interférence par ARN › Argonaute-independent, Dicer-dependent...
questionsmedicales.fr › Phénomènes microbiologiques › Phénomènes physiologiques viraux › Réplication virale › Argonaute-independent, Dicer-dependent...
questionsmedicales.fr › Acides nucléiques, nucléotides et nucléosides › Acides nucléiques › ARN › ARN viral › Argonaute-independent, Dicer-dependent...
questionsmedicales.fr › Acides aminés, peptides et protéines › Protéines › Protéines fongiques › Argonaute-independent, Dicer-dependent...
questionsmedicales.fr › Phénomènes génétiques › Structures génétiques › Conformation d'acide nucléique › ARN double brin › Argonaute-independent, Dicer-dependent...