Association of Cortical Lesions With Regional Glutamate, GABA,
Humans
Middle Aged
Female
Male
Adult
Inositol
/ metabolism
Aspartic Acid
/ analogs & derivatives
Glutamic Acid
/ metabolism
gamma-Aminobutyric Acid
/ metabolism
Cross-Sectional Studies
Cerebral Cortex
/ metabolism
Aged
Multiple Sclerosis
/ metabolism
Magnetic Resonance Imaging
Magnetic Resonance Spectroscopy
Multiple Sclerosis, Chronic Progressive
/ metabolism
Multiple Sclerosis, Relapsing-Remitting
/ diagnostic imaging
Young Adult
Proton Magnetic Resonance Spectroscopy
Journal
Neurology
ISSN: 1526-632X
Titre abrégé: Neurology
Pays: United States
ID NLM: 0401060
Informations de publication
Date de publication:
Jul 2024
Jul 2024
Historique:
medline:
13
6
2024
pubmed:
13
6
2024
entrez:
13
6
2024
Statut:
ppublish
Résumé
Cortical lesions contribute to disability in multiple sclerosis (MS), but their impact on regional neurotransmitter levels remains to be clarified. We tested the hypothesis that cortical lesions are associated with regional glutamate and gamma-aminobutyric acid (GABA) concentrations within the affected cortical region. In this cross-sectional study, we used structural 7T MRI to segment cortical lesions and 7T proton MR-spectroscopy of the bilateral sensorimotor hand areas to quantify regional GABA, glutamate, Forty-seven patients with MS (34 RRMS, 13 SPMS; 45.1 ± 12.5 years; 31 women) and 23 healthy controls (44.4 ± 13 years, 15 women) were studied. In patients, higher regional glutamate and lower regional GABA concentrations were associated with larger cortical lesion volume within the MR-spectroscopy voxel [glutamate: 0.61 (95% CI 0.19-1.03) log(mm Cortical lesions are associated with local increases in glutamate and a reduction in GABA concentration within the lesional or perilesional tissue. Further studies are needed to investigate the causal relationship between cortical lesions and changes in neurotransmitter concentrations.
Sections du résumé
BACKGROUND AND OBJECTIVES
OBJECTIVE
Cortical lesions contribute to disability in multiple sclerosis (MS), but their impact on regional neurotransmitter levels remains to be clarified. We tested the hypothesis that cortical lesions are associated with regional glutamate and gamma-aminobutyric acid (GABA) concentrations within the affected cortical region.
METHODS
METHODS
In this cross-sectional study, we used structural 7T MRI to segment cortical lesions and 7T proton MR-spectroscopy of the bilateral sensorimotor hand areas to quantify regional GABA, glutamate,
RESULTS
RESULTS
Forty-seven patients with MS (34 RRMS, 13 SPMS; 45.1 ± 12.5 years; 31 women) and 23 healthy controls (44.4 ± 13 years, 15 women) were studied. In patients, higher regional glutamate and lower regional GABA concentrations were associated with larger cortical lesion volume within the MR-spectroscopy voxel [glutamate: 0.61 (95% CI 0.19-1.03) log(mm
DISCUSSION
CONCLUSIONS
Cortical lesions are associated with local increases in glutamate and a reduction in GABA concentration within the lesional or perilesional tissue. Further studies are needed to investigate the causal relationship between cortical lesions and changes in neurotransmitter concentrations.
Identifiants
pubmed: 38870443
doi: 10.1212/WNL.0000000000209543
doi:
Substances chimiques
N-acetylaspartate
997-55-7
Inositol
4L6452S749
Aspartic Acid
30KYC7MIAI
Glutamic Acid
3KX376GY7L
gamma-Aminobutyric Acid
56-12-2
Types de publication
Journal Article
Langues
eng
Sous-ensembles de citation
IM