Targeting T cell plasticity in kidney and gut inflammation by pooled single-cell CRISPR screening.

Animals Humans Mice Single-Cell Analysis Th17 Cells / immunology Glomerulonephritis / immunology Cell Plasticity / immunology Kidney / immunology Mice, Inbred C57BL CRISPR-Cas Systems Colitis / immunology Inflammation / immunology Female Male Clustered Regularly Interspaced Short Palindromic Repeats / immunology

Journal

Science immunology
ISSN: 2470-9468
Titre abrégé: Sci Immunol
Pays: United States
ID NLM: 101688624

Informations de publication

Date de publication:
14 Jun 2024
Historique:
medline: 14 6 2024
pubmed: 14 6 2024
entrez: 14 6 2024
Statut: ppublish

Résumé

Pro-inflammatory CD4

Identifiants

DOI: 10.1126/sciimmunol.add6774 PMID: 38875317
pubmed: 38875317
doi: 10.1126/sciimmunol.add6774
doi:

Types de publication

Journal Article

Langues

eng

Sous-ensembles de citation

IM

Pagination

eadd6774

Auteurs

Leon U B Enk (LUB)

III. Department of Medicine, University Medical Center Hamburg-Eppendorf, Hamburg, Germany.
Hamburg Center for Translational Immunology (HCTI), University Medical Center Hamburg-Eppendorf, Hamburg, Germany.
Hamburg Center for Kidney Health (HCKH), University Medical Center Hamburg-Eppendorf, Hamburg, Germany.
ORCID: 0000-0003-4158-1772

Malte Hellmig (M)

III. Department of Medicine, University Medical Center Hamburg-Eppendorf, Hamburg, Germany.
Hamburg Center for Translational Immunology (HCTI), University Medical Center Hamburg-Eppendorf, Hamburg, Germany.
Hamburg Center for Kidney Health (HCKH), University Medical Center Hamburg-Eppendorf, Hamburg, Germany.
ORCID: 0000-0002-6692-5618

Kristoffer Riecken (K)

Department of Stem Cell Transplantation, Research Department Cell and Gene Therapy, University Medical Center Hamburg-Eppendorf, Hamburg, Germany.
ORCID: 0000-0001-9050-6766

Christoph Kilian (C)

III. Department of Medicine, University Medical Center Hamburg-Eppendorf, Hamburg, Germany.
I. Department of Medicine, University Medical Center Hamburg-Eppendorf, Hamburg, Germany.
ORCID: 0000-0003-0933-6152

Paul Datlinger (P)

CeMM Research Center for Molecular Medicine of the Austrian Academy of Sciences, Vienna, Austria.

Saskia L Jauch-Speer (SL)

Hamburg Center for Translational Immunology (HCTI), University Medical Center Hamburg-Eppendorf, Hamburg, Germany.

Tobias Neben (T)

III. Department of Medicine, University Medical Center Hamburg-Eppendorf, Hamburg, Germany.
Hamburg Center for Translational Immunology (HCTI), University Medical Center Hamburg-Eppendorf, Hamburg, Germany.
Hamburg Center for Kidney Health (HCKH), University Medical Center Hamburg-Eppendorf, Hamburg, Germany.
ORCID: 0009-0002-5706-8375

Zeba Sultana (Z)

III. Department of Medicine, University Medical Center Hamburg-Eppendorf, Hamburg, Germany.
Hamburg Center for Translational Immunology (HCTI), University Medical Center Hamburg-Eppendorf, Hamburg, Germany.
Hamburg Center for Kidney Health (HCKH), University Medical Center Hamburg-Eppendorf, Hamburg, Germany.
ORCID: 0000-0001-6610-9955

Varshi Sivayoganathan (V)

III. Department of Medicine, University Medical Center Hamburg-Eppendorf, Hamburg, Germany.
Hamburg Center for Translational Immunology (HCTI), University Medical Center Hamburg-Eppendorf, Hamburg, Germany.
Hamburg Center for Kidney Health (HCKH), University Medical Center Hamburg-Eppendorf, Hamburg, Germany.
ORCID: 0000-0003-4118-9156

Alina Borchers (A)

III. Department of Medicine, University Medical Center Hamburg-Eppendorf, Hamburg, Germany.
Hamburg Center for Translational Immunology (HCTI), University Medical Center Hamburg-Eppendorf, Hamburg, Germany.
Hamburg Center for Kidney Health (HCKH), University Medical Center Hamburg-Eppendorf, Hamburg, Germany.

Hans-Joachim Paust (HJ)

III. Department of Medicine, University Medical Center Hamburg-Eppendorf, Hamburg, Germany.
Hamburg Center for Translational Immunology (HCTI), University Medical Center Hamburg-Eppendorf, Hamburg, Germany.
Hamburg Center for Kidney Health (HCKH), University Medical Center Hamburg-Eppendorf, Hamburg, Germany.
ORCID: 0000-0003-2654-7293

Yu Zhao (Y)

Hamburg Center for Translational Immunology (HCTI), University Medical Center Hamburg-Eppendorf, Hamburg, Germany.
Institute of Medical Systems Biology, University Medical Center Hamburg-Eppendorf, Hamburg, Germany.
Center for Biomedical AI, University Medical Center Hamburg-Eppendorf, Hamburg, Germany.
ORCID: 0000-0003-2632-7530

Nariaki Asada (N)

III. Department of Medicine, University Medical Center Hamburg-Eppendorf, Hamburg, Germany.
Hamburg Center for Translational Immunology (HCTI), University Medical Center Hamburg-Eppendorf, Hamburg, Germany.
Hamburg Center for Kidney Health (HCKH), University Medical Center Hamburg-Eppendorf, Hamburg, Germany.

Shuya Liu (S)

III. Department of Medicine, University Medical Center Hamburg-Eppendorf, Hamburg, Germany.
Hamburg Center for Kidney Health (HCKH), University Medical Center Hamburg-Eppendorf, Hamburg, Germany.
ORCID: 0000-0001-6897-036X

Theodora Agalioti (T)

Hamburg Center for Translational Immunology (HCTI), University Medical Center Hamburg-Eppendorf, Hamburg, Germany.
I. Department of Medicine, University Medical Center Hamburg-Eppendorf, Hamburg, Germany.
ORCID: 0000-0002-5898-2751

Penelope Pelczar (P)

Hamburg Center for Translational Immunology (HCTI), University Medical Center Hamburg-Eppendorf, Hamburg, Germany.
I. Department of Medicine, University Medical Center Hamburg-Eppendorf, Hamburg, Germany.
ORCID: 0000-0001-7868-0024

Thorsten Wiech (T)

Institute of Pathology, Division of Nephropathology, University Medical Center Hamburg-Eppendorf, Hamburg, Germany.
ORCID: 0000-0003-4053-1474

Christoph Bock (C)

CeMM Research Center for Molecular Medicine of the Austrian Academy of Sciences, Vienna, Austria.
Institute of Artificial Intelligence and Decision Support, Center for Medical Statistics, Informatics, and Intelligent Systems, Medical University of Vienna, Vienna, Austria.
ORCID: 0000-0001-6091-3088

Tobias B Huber (TB)

III. Department of Medicine, University Medical Center Hamburg-Eppendorf, Hamburg, Germany.
Hamburg Center for Translational Immunology (HCTI), University Medical Center Hamburg-Eppendorf, Hamburg, Germany.
Hamburg Center for Kidney Health (HCKH), University Medical Center Hamburg-Eppendorf, Hamburg, Germany.
ORCID: 0000-0001-7175-5062

Samuel Huber (S)

Hamburg Center for Translational Immunology (HCTI), University Medical Center Hamburg-Eppendorf, Hamburg, Germany.
I. Department of Medicine, University Medical Center Hamburg-Eppendorf, Hamburg, Germany.
ORCID: 0000-0001-9325-8227

Stefan Bonn (S)

Hamburg Center for Translational Immunology (HCTI), University Medical Center Hamburg-Eppendorf, Hamburg, Germany.
Institute of Medical Systems Biology, University Medical Center Hamburg-Eppendorf, Hamburg, Germany.
Center for Biomedical AI, University Medical Center Hamburg-Eppendorf, Hamburg, Germany.
ORCID: 0000-0003-4366-5662

Nicola Gagliani (N)

Hamburg Center for Translational Immunology (HCTI), University Medical Center Hamburg-Eppendorf, Hamburg, Germany.
I. Department of Medicine, University Medical Center Hamburg-Eppendorf, Hamburg, Germany.
Department for General, Visceral and Thoracic Surgery, University Medical Center Hamburg-Eppendorf, Hamburg, Germany.
ORCID: 0000-0001-8514-1395

Boris Fehse (B)

Hamburg Center for Translational Immunology (HCTI), University Medical Center Hamburg-Eppendorf, Hamburg, Germany.
Department of Stem Cell Transplantation, Research Department Cell and Gene Therapy, University Medical Center Hamburg-Eppendorf, Hamburg, Germany.
ORCID: 0000-0001-9780-7211

Ulf Panzer (U)

III. Department of Medicine, University Medical Center Hamburg-Eppendorf, Hamburg, Germany.
Hamburg Center for Translational Immunology (HCTI), University Medical Center Hamburg-Eppendorf, Hamburg, Germany.
Hamburg Center for Kidney Health (HCKH), University Medical Center Hamburg-Eppendorf, Hamburg, Germany.
ORCID: 0000-0001-9449-0722

Christian F Krebs (CF)

III. Department of Medicine, University Medical Center Hamburg-Eppendorf, Hamburg, Germany.
Hamburg Center for Translational Immunology (HCTI), University Medical Center Hamburg-Eppendorf, Hamburg, Germany.
Hamburg Center for Kidney Health (HCKH), University Medical Center Hamburg-Eppendorf, Hamburg, Germany.
ORCID: 0000-0003-2739-5578

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Classifications MeSH

questionsmedicales.fr › Eucaryotes › Animaux › Targeting T cell plasticity in kidney and gut...
questionsmedicales.fr › Eucaryotes › Animaux › Chordés › Vertébrés › Mammifères › Eutheria › Primates › Haplorhini › Catarrhini › Hominidae › Humains › Targeting T cell plasticity in kidney and gut...
questionsmedicales.fr › Eucaryotes › Animaux › Chordés › Vertébrés › Mammifères › Eutheria › Rodentia › Muridae › Murinae › Souris › Targeting T cell plasticity in kidney and gut...
questionsmedicales.fr › Techniques d'investigation › Techniques cytologiques › Analyse sur cellule unique › Targeting T cell plasticity in kidney and gut...
questionsmedicales.fr › Systèmes sanguin et immunitaire › Système immunitaire › Leucocytes › Agranulocytes › Lymphocytes › Lymphocytes T › Sous-populations de lymphocytes T › Lymphocytes T auxiliaires › Cellules Th17 › Targeting T cell plasticity in kidney and gut...
questionsmedicales.fr › Maladies urogénitales › Maladies urologiques › Maladies du rein › Néphrite › Glomérulonéphrite › Targeting T cell plasticity in kidney and gut...
questionsmedicales.fr › Phénomènes physiologiques cellulaires › Transdifférenciation cellulaire › Plasticité cellulaire › Targeting T cell plasticity in kidney and gut...
questionsmedicales.fr › Appareil urogénital › Voies urinaires › Rein › Targeting T cell plasticity in kidney and gut...
questionsmedicales.fr › Eucaryotes › Animaux › Chordés › Vertébrés › Mammifères › Eutheria › Rodentia › Muridae › Murinae › Souris › Lignées consanguines de souris › Souris de lignée C57BL › Targeting T cell plasticity in kidney and gut...
questionsmedicales.fr › Phénomènes génétiques › Régulation de l'expression des gènes › Épigenèse génétique › Extinction de l'expression des gènes › Systèmes CRISPR-Cas › Targeting T cell plasticity in kidney and gut...
questionsmedicales.fr › Maladies de l'appareil digestif › Maladies gastro-intestinales › Maladies intestinales › Maladies du côlon › Colite › Targeting T cell plasticity in kidney and gut...
questionsmedicales.fr › États, signes et symptômes pathologiques › Processus pathologiques › Inflammation › Targeting T cell plasticity in kidney and gut...
questionsmedicales.fr › Phénomènes génétiques › Structures génétiques › Génome › Composants de génome › Séquences répétées en tandem › Clustered regularly interspaced short palindromic repeats › Targeting T cell plasticity in kidney and gut...