Modifications in the T arm of tRNA globally determine tRNA maturation, function, and cellular fitness.

RNA, Transfer / metabolism Escherichia coli / genetics Protein Biosynthesis Escherichia coli Proteins / metabolism tRNA Methyltransferases / metabolism RNA Processing, Post-Transcriptional
aminoacylation methylation protein synthesis pseudouridine tRNA modification

Journal

Proceedings of the National Academy of Sciences of the United States of America
ISSN: 1091-6490
Titre abrégé: Proc Natl Acad Sci U S A
Pays: United States
ID NLM: 7505876

Informations de publication

Date de publication:
25 Jun 2024
Historique:
medline: 18 6 2024
pubmed: 18 6 2024
entrez: 18 6 2024
Statut: ppublish

Résumé

Almost all elongator tRNAs (Transfer RNAs) harbor 5-methyluridine 54 and pseudouridine 55 in the T arm, generated by the enzymes TrmA and TruB, respectively, in

Identifiants

DOI: 10.1073/pnas.2401154121 PMID: 38889150
pubmed: 38889150
doi: 10.1073/pnas.2401154121
doi:

Substances chimiques

RNA, Transfer 9014-25-9
Escherichia coli Proteins 0
tRNA Methyltransferases EC 2.1.1.-

Types de publication

Journal Article

Langues

eng

Sous-ensembles de citation

IM

Pagination

e2401154121

Subventions

Organisme : Canadian Government | Natural Sciences and Engineering Research Council of Canada (NSERC)
ID : RGPIN-2020-04965
Organisme : Canadian Government | Natural Sciences and Engineering Research Council of Canada (NSERC)
ID : RGPAS-2020-00010

Déclaration de conflit d'intérêts

Competing interests statement:The authors declare no competing interest.

Auteurs

Sarah K Schultz (SK)

Department of Chemistry, University of Manitoba, Winnipeg, MB R3T 2N2, Canada.
Department of Chemistry and Biochemistry, Alberta RNA Research and Training Institute, University of Lethbridge, Lethbridge, AB T1K 3M4, Canada.

Christopher D Katanski (CD)

Department of Biochemistry & Molecular Biology, University of Chicago, Chicago, IL 60637.
ORCID: 0000-0002-1707-081X

Mateusz Halucha (M)

Department of Biochemistry & Molecular Biology, University of Chicago, Chicago, IL 60637.

Noah Peña (N)

Department of Molecular Genetics and Cell Biology, University of Chicago, Chicago, IL 60637.
ORCID: 0000-0002-9079-4638

Richard P Fahlman (RP)

Department of Biochemistry, University of Alberta, Edmonton, AB T6G 2H7, Canada.

Tao Pan (T)

Department of Biochemistry & Molecular Biology, University of Chicago, Chicago, IL 60637.

Ute Kothe (U)

Department of Chemistry, University of Manitoba, Winnipeg, MB R3T 2N2, Canada.
Department of Chemistry and Biochemistry, Alberta RNA Research and Training Institute, University of Lethbridge, Lethbridge, AB T1K 3M4, Canada.
ORCID: 0000-0002-2744-7334

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Classifications MeSH

questionsmedicales.fr › Acides nucléiques, nucléotides et nucléosides › Acides nucléiques › ARN › ARN de transfert › Modifications in the T arm of tRNA globally...
questionsmedicales.fr › Bactéries › Proteobacteria › Gammaproteobacteria › Enterobacteriaceae › Escherichia › Escherichia coli › Modifications in the T arm of tRNA globally...
questionsmedicales.fr › Phénomènes génétiques › Expression des gènes › Biosynthèse des protéines › Modifications in the T arm of tRNA globally...
questionsmedicales.fr › Acides aminés, peptides et protéines › Protéines › Protéines bactériennes › Protéines Escherichia coli › Modifications in the T arm of tRNA globally...
questionsmedicales.fr › Enzymes et coenzymes › Enzymes › Transferases › One-carbon group transferases › Methyltransferases › T-RNA methyltransferases › Modifications in the T arm of tRNA globally...
questionsmedicales.fr › Phénomènes génétiques › Régulation de l'expression des gènes › Maturation post-transcriptionnelle des ARN › Modifications in the T arm of tRNA globally...