Lysogeny destabilizes computationally simulated microbiomes.
Anna Karenina Principle
bacteriophage
diversity
lysogeny
microbiome
stability
Journal
Ecology letters
ISSN: 1461-0248
Titre abrégé: Ecol Lett
Pays: England
ID NLM: 101121949
Informations de publication
Date de publication:
Jun 2024
Jun 2024
Historique:
revised:
06
05
2024
received:
03
01
2024
accepted:
06
06
2024
medline:
26
6
2024
pubmed:
26
6
2024
entrez:
26
6
2024
Statut:
ppublish
Résumé
Microbiomes are ecosystems, and their stability can impact the health of their hosts. Theory predicts that predators influence ecosystem stability. Phages are key predators of bacteria in microbiomes, but phages are unusual predators because many have lysogenic life cycles. It has been hypothesized that lysogeny can destabilize microbiomes, but lysogeny has no direct analog in classical ecological theory, and no formal theory exists. We studied the stability of computationally simulated microbiomes with different numbers of temperate (lysogenic) and virulent (obligate lytic) phage species. Bacterial populations were more likely to fluctuate over time when there were more temperate phages species. After disturbances, bacterial populations returned to their pre-disturbance densities more slowly when there were more temperate phage species, but cycles engendered by disturbances dampened more slowly when there were more virulent phage species. Our work offers the first formal theory linking lysogeny to microbiome stability.
Types de publication
Journal Article
Langues
eng
Sous-ensembles de citation
IM
Pagination
e14464Subventions
Organisme : Horizon 2020 Framework Programme
ID : 767015
Organisme : Biotechnology and Biological Sciences Research Council
ID : BB/T008725/1
Pays : United Kingdom
Informations de copyright
© 2024 The Author(s). Ecology Letters published by John Wiley & Sons Ltd.
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