De Novo Synthesis of Resveratrol from Sucrose by Metabolically Engineered
Resveratrol
/ metabolism
Yarrowia
/ genetics
Metabolic Engineering
/ methods
Sucrose
/ metabolism
Acyltransferases
/ genetics
Vitis
/ microbiology
Coenzyme A Ligases
/ metabolism
Malonyl Coenzyme A
/ metabolism
Nicotiana
/ genetics
Rhodotorula
/ genetics
Fermentation
Arabidopsis
/ genetics
Ammonia-Lyases
Bacterial Proteins
Yarrowia lipolytica
metabolic engineering
microbial cell factory
resveratrol
Journal
Biomolecules
ISSN: 2218-273X
Titre abrégé: Biomolecules
Pays: Switzerland
ID NLM: 101596414
Informations de publication
Date de publication:
16 Jun 2024
16 Jun 2024
Historique:
received:
21
04
2024
revised:
10
06
2024
accepted:
14
06
2024
medline:
27
6
2024
pubmed:
27
6
2024
entrez:
27
6
2024
Statut:
epublish
Résumé
Resveratrol, a phenylpropanoid compound, exhibits diverse pharmacological properties, making it a valuable candidate for health and disease management. However, the demand for resveratrol exceeds the capacity of plant extraction methods, necessitating alternative production strategies. Microbial synthesis offers several advantages over plant-based approaches and presents a promising alternative.
Identifiants
pubmed: 38927115
pii: biom14060712
doi: 10.3390/biom14060712
pii:
doi:
Substances chimiques
Resveratrol
Q369O8926L
Sucrose
57-50-1
stilbene synthase
EC 2.3.1.-
Acyltransferases
EC 2.3.-
Coenzyme A Ligases
EC 6.2.1.-
4-coumarate-CoA ligase
EC 6.2.1.12
L-tyrosine ammonia-lyase
EC 4.3.1.-
Malonyl Coenzyme A
524-14-1
malonyl-CoA synthetase
EC 6.2.1.-
Ammonia-Lyases
EC 4.3.1.-
Bacterial Proteins
0
Types de publication
Journal Article
Langues
eng
Sous-ensembles de citation
IM
Subventions
Organisme : National Natural Science Foundation of China
ID : NSFC32170090
Organisme : Wuhan Science and Technology Major Special "Choke Neck" Key Technological Breakthrough Project
ID : 2023020302020708