Structural Evaluation of a Nitroreductase Engineered for Improved Activation of the 5-Nitroimidazole PET Probe SN33623.
CB1954
NfsB
SN33623
cancer gene therapy
crystal structure
metronidazole
prodrug
targeted cellular ablation
theranostic imaging
type I nitroreductase
Journal
International journal of molecular sciences
ISSN: 1422-0067
Titre abrégé: Int J Mol Sci
Pays: Switzerland
ID NLM: 101092791
Informations de publication
Date de publication:
15 Jun 2024
15 Jun 2024
Historique:
received:
25
05
2024
revised:
12
06
2024
accepted:
13
06
2024
medline:
27
6
2024
pubmed:
27
6
2024
entrez:
27
6
2024
Statut:
epublish
Résumé
Bacterial nitroreductase enzymes capable of activating imaging probes and prodrugs are valuable tools for gene-directed enzyme prodrug therapies and targeted cell ablation models. We recently engineered a nitroreductase (
Identifiants
pubmed: 38928299
pii: ijms25126593
doi: 10.3390/ijms25126593
pii:
doi:
Substances chimiques
Nitroreductases
EC 1.7.-
Nitroimidazoles
0
Metronidazole
140QMO216E
Prodrugs
0
4-nitroimidazole
Y8U32AZ5O7
Escherichia coli Proteins
0
tretazicar
7865D5D01M
NfsB protein, E coli
EC 1.7.-
Aziridines
0
Types de publication
Journal Article
Langues
eng
Sous-ensembles de citation
IM
Subventions
Organisme : NIH HHS
ID : RF1MH126731
Pays : United States
Organisme : Royal Society Te Apārangi
ID : VUW1902
Organisme : the Royal Society of New Zealand Marsden Fund
ID : (contract VUW1902 awarded to D.F.A.)
Organisme : the US National Institutes of Health
ID : (contract RF1MH126731 awarded to J.S.M. and D.F.A.)