Developing guanine base editors for G-to-T editing in rice.
Journal
Journal of integrative plant biology
ISSN: 1744-7909
Titre abrégé: J Integr Plant Biol
Pays: China (Republic : 1949- )
ID NLM: 101250502
Informations de publication
Date de publication:
Aug 2024
Aug 2024
Historique:
received:
27
03
2024
accepted:
27
05
2024
medline:
16
8
2024
pubmed:
27
6
2024
entrez:
27
6
2024
Statut:
ppublish
Résumé
Two guanine base editors created using an engineered N-methylpurine DNA glycosylase with CRISPR systems achieved targeted G-to-T editing with 4.94-12.50% efficiency in rice (Oryza sativa). The combined use of the DNA glycosylase and deaminases enabled co-editing of target guanines with adenines or cytosines.
Substances chimiques
Guanine
5Z93L87A1R
DNA Glycosylases
EC 3.2.2.-
Thymine
QR26YLT7LT
Types de publication
Journal Article
Langues
eng
Sous-ensembles de citation
IM
Pagination
1557-1560Subventions
Organisme : Biological Breeding-Major Projects
ID : 2023ZD04074
Organisme : Nanfan special project of the Chinese Academy of Agricultural Sciences
ID : YBXM2313
Organisme : Hainan Seed Industry Laboratory
ID : B23CJ0208
Informations de copyright
© 2024 The Author(s). Journal of Integrative Plant Biology published by John Wiley & Sons Australia, Ltd on behalf of Institute of Botany, Chinese Academy of Sciences.
Références
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