An RNA pseudoknot mediates toxin translation and antitoxin inhibition.
RNA structure
posttranscriptional regulation
small RNA
toxin–antitoxin
translation control
Journal
Proceedings of the National Academy of Sciences of the United States of America
ISSN: 1091-6490
Titre abrégé: Proc Natl Acad Sci U S A
Pays: United States
ID NLM: 7505876
Informations de publication
Date de publication:
02 Jul 2024
02 Jul 2024
Historique:
medline:
27
6
2024
pubmed:
27
6
2024
entrez:
27
6
2024
Statut:
ppublish
Résumé
Type I toxin-antitoxin systems (T1TAs) are bipartite bacterial loci encoding a growth-inhibitory toxin and an antitoxin small RNA (sRNA). In many of these systems, the transcribed toxin mRNA is translationally inactive, but becomes translation-competent upon ribonucleolytic processing. The antitoxin sRNA targets the processed mRNA to inhibit its translation. This two-level control mechanism prevents cotranscriptional translation of the toxin and allows its synthesis only when the antitoxin is absent. Contrary to this, we found that the
Identifiants
pubmed: 38935561
doi: 10.1073/pnas.2403063121
doi:
Substances chimiques
RNA, Bacterial
0
RNA, Messenger
0
Bacterial Toxins
0
Antitoxins
0
Types de publication
Journal Article
Langues
eng
Sous-ensembles de citation
IM
Pagination
e2403063121Subventions
Organisme : Vetenskapsr&ådet (VR)
ID : 2021-04657
Organisme : Uppsala Antibiotic Center
ID : 2021
Déclaration de conflit d'intérêts
Competing interests statement:The authors declare no competing interest.