Divergent synthesis of complex withanolides enabled by a scalable route and late-stage functionalization.

Withanolides / chemistry Chemistry Techniques, Synthetic Molecular Structure Biological Products / chemistry

Journal

Science advances
ISSN: 2375-2548
Titre abrégé: Sci Adv
Pays: United States
ID NLM: 101653440

Informations de publication

Date de publication:
28 Jun 2024
Historique:
medline: 28 6 2024
pubmed: 28 6 2024
entrez: 28 6 2024
Statut: ppublish

Résumé

Withanolides are a group of naturally occurring C

Identifiants

DOI: 10.1126/sciadv.adp9375 PMID: 38941454
pubmed: 38941454
doi: 10.1126/sciadv.adp9375
doi:

Substances chimiques

Withanolides 0
Biological Products 0

Types de publication

Journal Article

Langues

eng

Sous-ensembles de citation

IM

Pagination

eadp9375

Auteurs

Wen Che (W)

Drug Discovery Department, H. Lee Moffitt Cancer Center and Research Institute, 12902 Magnolia Drive, Tampa, FL 33612, USA.
ORCID: 0009-0004-8912-6423

Lukasz Wojitas (L)

Department of Chemistry, University of South Florida; Tampa, FL 33620, USA.
ORCID: 0000-0003-0545-0302

Chuan Shan (C)

Department of Chemistry, University of South Florida; Tampa, FL 33620, USA.
ORCID: 0000-0002-5173-1335

Justin M Lopchuk (JM)

Drug Discovery Department, H. Lee Moffitt Cancer Center and Research Institute, 12902 Magnolia Drive, Tampa, FL 33612, USA.
Department of Chemistry, University of South Florida; Tampa, FL 33620, USA.
Department of Oncologic Sciences, College of Medicine, University of South Florida, Tampa, FL 33612, USA.
ORCID: 0000-0002-6910-6132

Articles similaires

Withaferin a modulation of microglia autophagy mitigates neuroinflammation and enhances cognitive function in POCD.

Haijun Hu, Bingbing Cao, Dan Huang et al.
1.00
Withanolides Animals Microglia Autophagy Mice

Expanding the antiprotozoal activity and the mechanism of action of n-butyl and iso-butyl ester of quinoxaline-1,4-di-

Alonzo González-González, Oscar Sánchez-Sánchez, Lilián Yépez-Mulia et al.
1.00
Giardia lamblia Trichomonas vaginalis Entamoeba histolytica Antiprotozoal Agents Quinoxalines

Wnt/β-catenin signaling pathway: proteins' roles in osteoporosis and cancer diseases and the regulatory effects of natural compounds on osteoporosis.

Xiaohao Wang, Zechao Qu, Songchuan Zhao et al.
1.00
Humans Osteoporosis Wnt Signaling Pathway Animals Osteoblasts

Proactive therapeutic drug monitoring of biologic drugs in adult patients with inflammatory bowel disease, inflammatory arthritis, or psoriasis: a clinical practice guideline.

Leticia Kawano-Dourado, Eirik Klami Kristianslund, Dena Zeraatkar et al.
1.00
Humans Drug Monitoring Inflammatory Bowel Diseases Psoriasis Adult

Classifications MeSH

questionsmedicales.fr › Facteurs biologiques › Composés phytochimiques › Phytostérols › Withanolides › Divergent synthesis of complex withanolides...
questionsmedicales.fr › Technologie, industrie et agriculture › Technologie › Technologie pharmaceutique › Techniques de chimie synthétique › Divergent synthesis of complex withanolides...
questionsmedicales.fr › Phénomènes chimiques › Structure moléculaire › Divergent synthesis of complex withanolides...
questionsmedicales.fr › Mélanges complexes › Produits biologiques › Divergent synthesis of complex withanolides...