An immune-adrenergic pathway induces lethal levels of platelet-activating factor in mice.
Journal
Communications biology
ISSN: 2399-3642
Titre abrégé: Commun Biol
Pays: England
ID NLM: 101719179
Informations de publication
Date de publication:
29 Jun 2024
29 Jun 2024
Historique:
received:
12
08
2023
accepted:
24
06
2024
medline:
2
7
2024
pubmed:
2
7
2024
entrez:
1
7
2024
Statut:
epublish
Résumé
Acute immune responses with excess production of cytokines, lipid/chemical mediators, or coagulation factors, often result in lethal damage. In addition, the innate immune system utilizes multiple types of receptors that recognize neurotransmitters as well as pathogen-associated molecular patterns, making immune responses complex and clinically unpredictable. We here report an innate immune and adrenergic link inducing lethal levels of platelet-activating factor. Injecting mice with toll-like receptor (TLR) 4 ligand lipopolysaccharide (LPS), cell wall N-glycans of Candida albicans, and the α
Identifiants
pubmed: 38951147
doi: 10.1038/s42003-024-06498-7
pii: 10.1038/s42003-024-06498-7
doi:
Substances chimiques
Platelet Activating Factor
0
Lipopolysaccharides
0
1-Acylglycerophosphocholine O-Acyltransferase
EC 2.3.1.23
Toll-Like Receptor 4
0
Adrenergic alpha-2 Receptor Agonists
0
Types de publication
Journal Article
Langues
eng
Sous-ensembles de citation
IM
Pagination
782Informations de copyright
© 2024. The Author(s).
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