Assessing seasonal variations of biomarkers in inflammatory bowel disease.
Humans
Seasons
Biomarkers
/ blood
Female
Colitis, Ulcerative
/ blood
Crohn Disease
/ blood
Male
Leukocyte L1 Antigen Complex
/ analysis
Adult
C-Reactive Protein
/ analysis
Feces
/ chemistry
Middle Aged
Blood Sedimentation
Vitamin D
/ blood
Young Adult
Aged
Disease Progression
Inflammation Mediators
/ blood
Hexosaminidases
Journal
European journal of gastroenterology & hepatology
ISSN: 1473-5687
Titre abrégé: Eur J Gastroenterol Hepatol
Pays: England
ID NLM: 9000874
Informations de publication
Date de publication:
01 Aug 2024
01 Aug 2024
Historique:
medline:
8
7
2024
pubmed:
8
7
2024
entrez:
8
7
2024
Statut:
ppublish
Résumé
Inflammatory bowel diseases are chronic pathologies characterized by a complex interplay of genetic and environmental factors, as well as aberrant immune responses. This study aimed to investigate inflammation markers' seasonality and association with disease exacerbation episodes in patients with Crohn's disease and ulcerative colitis. 284 patients were classified based on clinical, endoscopic, and histopathological criteria. Systemic inflammation was evaluated using C-reactive protein (CRP), erythrocyte sedimentation rate (ESR), and chitotriosidase, while fecal calprotectin was measured to assess intestinal inflammation. Serum vitamin D levels and the seasonality of an activity score that combines several clinical and biological parameters were also evaluated. The peak number of patients reporting endoscopic activity occurred in autumn for Crohn's disease (82%) and spring for ulcerative colitis (95%). Regarding histological activity, spring saw the highest number of patients for both diseases (72% for Crohn's disease; 87% for ulcerative colitis). Most of the inflammatory markers exhibited lower values during winter. Systemic inflammatory markers follow a slightly different trend than fecal calprotectin and differ in the two pathologies. The maximum values of intestinal inflammation were observed in autumn for Crohn's disease (784 µg/g) and in spring for ulcerative colitis (1269 µg/g). Serum vitamin D concentrations were consistently low throughout the year. Statistical analysis revealed differences between the seasons for CRP and ESR (P < 0.05). The evolution of flares and inflammatory markers in Crohn's disease and ulcerative colitis displayed distinct seasonal patterns. Systemic inflammation did not consistently parallel intestinal inflammation.
Identifiants
pubmed: 38973542
doi: 10.1097/MEG.0000000000002795
pii: 00042737-202408000-00003
doi:
Substances chimiques
Biomarkers
0
Leukocyte L1 Antigen Complex
0
C-Reactive Protein
9007-41-4
Vitamin D
1406-16-2
chitotriosidase
EC 3.2.1.-
Inflammation Mediators
0
Hexosaminidases
EC 3.2.1.-
Types de publication
Journal Article
Langues
eng
Sous-ensembles de citation
IM
Pagination
993-999Informations de copyright
Copyright © 2024 Wolters Kluwer Health, Inc. All rights reserved.
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