Structure-Based Analysis of Cefaclor Pharmacokinetic Diversity According to Human Peptide Transporter-1 Genetic Polymorphism.

Humans Peptide Transporter 1 / genetics Cefaclor / pharmacokinetics Exons / genetics Genotype Polymorphism, Genetic Anti-Bacterial Agents / pharmacokinetics Polymorphism, Single Nucleotide Models, Molecular
PEPT1 SLC15A1 exons 5 and 16 cefaclor inter-individual variability pharmacokinetics

Journal

International journal of molecular sciences
ISSN: 1422-0067
Titre abrégé: Int J Mol Sci
Pays: Switzerland
ID NLM: 101092791

Informations de publication

Date de publication:
22 Jun 2024
Historique:
received: 22 05 2024
revised: 15 06 2024
accepted: 20 06 2024
medline: 13 7 2024
pubmed: 13 7 2024
entrez: 13 7 2024
Statut: epublish

Résumé

Cefaclor is a substrate of human-peptide-transporter-1 (PEPT1), and the impact of inter-individual pharmacokinetic variation due to genetic polymorphisms of solute-carrier-family-15-member-1 (

Identifiants

DOI: 10.3390/ijms25136880 PMID: 38999989
pubmed: 38999989
pii: ijms25136880
doi: 10.3390/ijms25136880
pii:
doi:

Substances chimiques

Peptide Transporter 1 0
Cefaclor 69K7K19H4L
SLC15A1 protein, human 0
Anti-Bacterial Agents 0

Types de publication

Journal Article

Langues

eng

Sous-ensembles de citation

IM

Subventions

Organisme : National Research Foundation of Korea
ID : RS-2023-00245453

Auteurs

Ji-Hun Jang (JH)

College of Pharmacy, Sunchon National University, 255 Jungang-ro, Suncheon-si 57922, Republic of Korea.

Seung-Hyun Jeong (SH)

College of Pharmacy, Sunchon National University, 255 Jungang-ro, Suncheon-si 57922, Republic of Korea.
College of Pharmacy and Research Institute of Life and Pharmaceutical Sciences, Sunchon National University, Suncheon-si 57922, Republic of Korea.
ORCID: 0000-0002-7515-0631

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Classifications MeSH

questionsmedicales.fr › Eucaryotes › Animaux › Chordés › Vertébrés › Mammifères › Eutheria › Primates › Haplorhini › Catarrhini › Hominidae › Humains › Structure-Based Analysis of Cefaclor...
questionsmedicales.fr › Acides aminés, peptides et protéines › Protéines › Protéines membranaires › Protéines de transport membranaire › Protéines transporteurs de solutés › Transporteur-1 de peptides › Structure-Based Analysis of Cefaclor...
questionsmedicales.fr › Composés hétérocycliques › Composés hétérocycliques à cycles fusionnés › Composés hétérobicycliques › bêta-Lactames › Céphalosporines › Céfalexine › Céfaclor › Structure-Based Analysis of Cefaclor...
questionsmedicales.fr › Phénomènes génétiques › Structures génétiques › Génome › Composants de génome › Gènes › Composants de gène › Exons › Structure-Based Analysis of Cefaclor...
questionsmedicales.fr › Phénomènes génétiques › Génotype › Structure-Based Analysis of Cefaclor...
questionsmedicales.fr › Phénomènes génétiques › Variation génétique › Polymorphisme génétique › Structure-Based Analysis of Cefaclor...
questionsmedicales.fr › Actions chimiques et utilisations › Actions pharmacologiques › Utilisations thérapeutiques › Anti-infectieux › Antibactériens › Structure-Based Analysis of Cefaclor...
questionsmedicales.fr › Phénomènes génétiques › Variation génétique › Polymorphisme génétique › Polymorphisme de nucléotide simple › Structure-Based Analysis of Cefaclor...
questionsmedicales.fr › Techniques d'investigation › Modèles théoriques › Modèles moléculaires › Structure-Based Analysis of Cefaclor...