Cell-cycle dependence on the biological effects of boron neutron capture therapy and its modification by polyvinyl alcohol.

Humans Boron Neutron Capture Therapy / methods HeLa Cells Polyvinyl Alcohol / chemistry Cell Cycle / radiation effects Boron Compounds / pharmacology Phenylalanine / analogs & derivatives
BNCT BPA CR-39 detector Cell cycle Heavy ions PVA

Journal

Scientific reports
ISSN: 2045-2322
Titre abrégé: Sci Rep
Pays: England
ID NLM: 101563288

Informations de publication

Date de publication:
19 Jul 2024
Historique:
received: 15 04 2024
accepted: 08 07 2024
medline: 20 7 2024
pubmed: 20 7 2024
entrez: 19 7 2024
Statut: epublish

Résumé

Boron neutron capture therapy (BNCT) is a unique radiotherapy of selectively eradicating tumor cells using boron compounds (e.g., 4-borono-L-phenylalanine [BPA]) that are heterogeneously taken up at the cellular level. Such heterogenicity potentially reduces the curative efficiency. However, the effects of temporospatial heterogenicity on cell killing remain unclear. With the technical combination of radiation track detector and biophysical simulations, this study revealed the cell cycle-dependent heterogenicity of BPA uptake and subsequent biological effects of BNCT on HeLa cells expressing fluorescent ubiquitination-based cell cycle indicators, as well as the modification effects of polyvinyl alcohol (PVA). The results showed that the BPA concentration in the S/G

Identifiants

DOI: 10.1038/s41598-024-67041-6 PMID: 39030350
pubmed: 39030350
doi: 10.1038/s41598-024-67041-6
pii: 10.1038/s41598-024-67041-6
doi:

Substances chimiques

Polyvinyl Alcohol 9002-89-5
Boron Compounds 0
Phenylalanine 47E5O17Y3R

Types de publication

Journal Article

Langues

eng

Sous-ensembles de citation

IM

Pagination

16696

Informations de copyright

© 2024. The Author(s).

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Auteurs

Yusuke Matsuya (Y)

Nuclear Science and Engineering Center, Japan Atomic Energy Agency, Tokai, 319-1195, Japan. matsuya.yusuke@hs.hokudai.ac.jp.
Faculty of Health Sciences, Hokkaido University, Sapporo, 060-0812, Japan. matsuya.yusuke@hs.hokudai.ac.jp.

Tatsuhiko Sato (T)

Nuclear Science and Engineering Center, Japan Atomic Energy Agency, Tokai, 319-1195, Japan.

Tamon Kusumoto (T)

National Institutes for Quantum and Radiological Science and Technology, Chiba, 263-8555, Japan.

Yoshie Yachi (Y)

Graduate School of Health Sciences, Hokkaido University, Sapporo, 060-0812, Japan.

Ryosuke Seino (R)

Graduate School of Health Sciences, Hokkaido University, Sapporo, 060-0812, Japan.

Misako Miwa (M)

Department of Quantum Science and Energy Engineering, Graduate School of Engineering, Tohoku University, Sendai, 980-8579, Japan.

Masayori Ishikawa (M)

Faculty of Health Sciences, Hokkaido University, Sapporo, 060-0812, Japan.

Shigeo Matsuyama (S)

Department of Quantum Science and Energy Engineering, Graduate School of Engineering, Tohoku University, Sendai, 980-8579, Japan.

Hisanori Fukunaga (H)

Faculty of Health Sciences, Hokkaido University, Sapporo, 060-0812, Japan. hisanori.fukunaga@hs.hokudai.ac.jp.
Center for Environmental and Health Sciences, Hokkaido University, Sapporo, 060-0812, Japan. hisanori.fukunaga@hs.hokudai.ac.jp.
Institute of Development, Aging and Cancer, Tohoku University, Sendai, 980-8575, Japan. hisanori.fukunaga@hs.hokudai.ac.jp.

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Classifications MeSH

questionsmedicales.fr › Eucaryotes › Animaux › Chordés › Vertébrés › Mammifères › Eutheria › Primates › Haplorhini › Catarrhini › Hominidae › Humains › Cell-cycle dependence on the biological...
questionsmedicales.fr › Thérapeutique › Radiothérapie › Radiothérapie de haute énergie › Thérapie par capture de neutrons › Thérapie par capture de neutrons par le bore › Cell-cycle dependence on the biological...
questionsmedicales.fr › Cellules › Cellules épithéliales › Cellules HeLa › Cell-cycle dependence on the biological...
questionsmedicales.fr › Technologie, industrie et agriculture › Produits manufacturés › Matériaux biomédicaux et dentaires › Polymères › Matières plastiques › Polyvinyles › Poly(alcool vinylique) › Cell-cycle dependence on the biological...
questionsmedicales.fr › Phénomènes physiologiques cellulaires › Cycle cellulaire › Cell-cycle dependence on the biological...
questionsmedicales.fr › Composés chimiques organiques › Composés du bore › Cell-cycle dependence on the biological...
questionsmedicales.fr › Acides aminés, peptides et protéines › Acides aminés › Acides aminés essentiels › Phénylalanine › Cell-cycle dependence on the biological...