Outcomes of Deceased Donor Kidney Recipients From the Same Donor Based on Donor-Recipient Sex Discordance.
Humans
Male
Female
Kidney Transplantation
Graft Rejection
/ etiology
Graft Survival
Middle Aged
Tissue Donors
Risk Factors
Follow-Up Studies
Adult
Sex Factors
Prognosis
Retrospective Studies
Postoperative Complications
Kidney Failure, Chronic
/ surgery
Transplant Recipients
/ statistics & numerical data
Glomerular Filtration Rate
Kidney Function Tests
Survival Rate
acute rejection
death‐censored graft failure
deceased donor kidney transplantation
sex discordance
Journal
Clinical transplantation
ISSN: 1399-0012
Titre abrégé: Clin Transplant
Pays: Denmark
ID NLM: 8710240
Informations de publication
Date de publication:
Jul 2024
Jul 2024
Historique:
revised:
21
06
2024
received:
17
01
2024
accepted:
30
06
2024
medline:
21
7
2024
pubmed:
21
7
2024
entrez:
21
7
2024
Statut:
ppublish
Résumé
Outcomes of deceased donor kidney transplant (DDKT) recipients from the same donor with donor-recipient sex discordance have been studied with inconsistent results. Adult DDKT where both kidneys from the same donor occurred at our center in two different recipients of different sexes were included. Outcomes were analyzed separately for male and female donors, based on the concordance or discordance between donor-recipient sex: Male-male (M-m) versus Male to female (M-f) or vice versa, F-f versus F-m. Acute rejection (AR) and uncensored graft failure were primary outcomes of interest. The univariate and multivariate risks for AR and graft failure were conducted using the Cox proportional hazards model and log-rank tests. A total of 130 donors, 84 male and 46 female fulfilled our selection criteria and were transplanted in 260 recipients. With respect to the concordant groups (M-m or F-f), sex discordance was not significantly associated with the risk of rejection in multivariate analysis (M-f vs. M-m HR 1.15 [0.53-2.53, P = 0.72]; F-m vs. F-f HR 1.77 [0.71-4.39, P = 0.23]). Sex discordance was also not significantly associated with graft failure in multivariate analysis. Interestingly, risk factors for AR differed among male donors and female donors. The higher calculated panel reactive antibodies (cPRA) and nonwhite recipients were at increased risk for AR in F-m, but not in M-f. Donor-recipient sex discordance was not significantly associated with AR or graft failure. Risk factors for AR may differ across male and female donors.
Types de publication
Journal Article
Langues
eng
Sous-ensembles de citation
IM
Pagination
e15409Informations de copyright
© 2024 The Author(s). Clinical Transplantation published by John Wiley & Sons Ltd.
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