Remodeling of perturbed chromatin can initiate de novo transcriptional and post-transcriptional silencing.

Neurospora crassa / genetics Gene Silencing Chromatin Assembly and Disassembly Transcription, Genetic Chromatin / metabolism Heterochromatin / metabolism Fungal Proteins / metabolism Gene Expression Regulation, Fungal Transcription Factors / metabolism Nucleosomes / metabolism
Neurospora constitutive heterochromatin post-transcriptional gene silencing quelling transcriptional gene silencing

Journal

Proceedings of the National Academy of Sciences of the United States of America
ISSN: 1091-6490
Titre abrégé: Proc Natl Acad Sci U S A
Pays: United States
ID NLM: 7505876

Informations de publication

Date de publication:
30 Jul 2024
Historique:
medline: 26 7 2024
pubmed: 26 7 2024
entrez: 25 7 2024
Statut: ppublish

Résumé

In eukaryotes, repetitive DNA can become silenced de novo, either transcriptionally or post-transcriptionally, by processes independent of strong sequence-specific cues. The mechanistic nature of such processes remains poorly understood. We found that in the fungus

Identifiants

DOI: 10.1073/pnas.2402944121 PMID: 39052837
pubmed: 39052837
doi: 10.1073/pnas.2402944121
doi:

Substances chimiques

Chromatin 0
Heterochromatin 0
Fungal Proteins 0
Transcription Factors 0
Nucleosomes 0

Types de publication

Journal Article

Langues

eng

Sous-ensembles de citation

IM

Pagination

e2402944121

Subventions

Organisme : Agence Nationale de la Recherche (ANR)
ID : ANR-19-CE12-0002
Organisme : Agence Nationale de la Recherche (ANR)
ID : ANR-10-LABX-0062
Organisme : Agence Nationale de la Recherche (ANR)
ID : ANR-11-LABX-0044
Organisme : Agence Nationale de la Recherche (ANR)
ID : ANR-10-IDEX-0001-02
Organisme : Agence Nationale de la Recherche (ANR)
ID : ANR-10-INBS-04

Déclaration de conflit d'intérêts

Competing interests statement:The authors declare no competing interest.

Auteurs

Florian Carlier (F)

Institut Pasteur, Department of Mycology, Molecular Genetics and Epigenetics Unit, Université Paris Cité, Paris 75015, France.

Sebastian Castro Ramirez (S)

Institut Pasteur, Department of Mycology, Molecular Genetics and Epigenetics Unit, Université Paris Cité, Paris 75015, France.

Jaafar Kilani (J)

Institut Pasteur, Department of Mycology, Molecular Genetics and Epigenetics Unit, Université Paris Cité, Paris 75015, France.

Sara Chehboub (S)

Institut Pasteur, Department of Mycology, Molecular Genetics and Epigenetics Unit, Université Paris Cité, Paris 75015, France.
ORCID: 0009-0008-9239-2158

Isabelle Loïodice (I)

Institut Curie, UMR3664 Nuclear Dynamics, CNRS, Université Paris Sciences et Lettres, Sorbonne Université, Paris 75005, France.
ORCID: 0009-0004-5198-8351

Angela Taddei (A)

Institut Curie, UMR3664 Nuclear Dynamics, CNRS, Université Paris Sciences et Lettres, Sorbonne Université, Paris 75005, France.
ORCID: 0000-0002-3217-0739

Eugene Gladyshev (E)

Institut Pasteur, Department of Mycology, Molecular Genetics and Epigenetics Unit, Université Paris Cité, Paris 75015, France.
ORCID: 0000-0002-4074-4966

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Classifications MeSH

questionsmedicales.fr › Eucaryotes › Champignons › Ascomycota › Sordariales › Neurospora › Neurospora crassa › Remodeling of perturbed chromatin can initiate...
questionsmedicales.fr › Phénomènes génétiques › Régulation de l'expression des gènes › Épigenèse génétique › Extinction de l'expression des gènes › Remodeling of perturbed chromatin can initiate...
questionsmedicales.fr › Phénomènes génétiques › Régulation de l'expression des gènes › Assemblage et désassemblage de la chromatine › Remodeling of perturbed chromatin can initiate...
questionsmedicales.fr › Phénomènes génétiques › Expression des gènes › Transcription génétique › Remodeling of perturbed chromatin can initiate...
questionsmedicales.fr › Phénomènes génétiques › Structures génétiques › Structures de chromosome › Chromatine › Remodeling of perturbed chromatin can initiate...
questionsmedicales.fr › Phénomènes génétiques › Structures génétiques › Structures de chromosome › Chromatine › Hétérochromatine › Remodeling of perturbed chromatin can initiate...
questionsmedicales.fr › Acides aminés, peptides et protéines › Protéines › Protéines fongiques › Remodeling of perturbed chromatin can initiate...
questionsmedicales.fr › Phénomènes génétiques › Régulation de l'expression des gènes › Régulation de l'expression des gènes fongiques › Remodeling of perturbed chromatin can initiate...
questionsmedicales.fr › Acides aminés, peptides et protéines › Protéines › Facteurs de transcription › Remodeling of perturbed chromatin can initiate...
questionsmedicales.fr › Phénomènes génétiques › Structures génétiques › Structures de chromosome › Chromatine › Nucléosomes › Remodeling of perturbed chromatin can initiate...