The RPD3L deacetylation complex is required for facultative heterochromatin repression in

Neurospora crassa / genetics Heterochromatin / metabolism Histones / metabolism Gene Expression Regulation, Fungal Fungal Proteins / metabolism Acetylation Gene Silencing Methylation Histone Deacetylases / metabolism
H3K27 methylation epigenetics histone modification polycomb repressive complex transcriptional silencing

Journal

Proceedings of the National Academy of Sciences of the United States of America
ISSN: 1091-6490
Titre abrégé: Proc Natl Acad Sci U S A
Pays: United States
ID NLM: 7505876

Informations de publication

Date de publication:
06 Aug 2024
Historique:
medline: 29 7 2024
pubmed: 29 7 2024
entrez: 29 7 2024
Statut: ppublish

Résumé

Repression of facultative heterochromatin is essential for developmental processes in numerous organisms. Methylation of histone H3 lysine 27 (H3K27) by Polycomb repressive complex 2 is a prominent feature of facultative heterochromatin in both fungi and higher eukaryotes. Although this methylation is frequently associated with silencing, the detailed mechanism of repression remains incompletely understood. We utilized a forward genetics approach to identify genes required to maintain silencing at facultative heterochromatin genes in

Identifiants

DOI: 10.1073/pnas.2404770121 PMID: 39074265
pubmed: 39074265
doi: 10.1073/pnas.2404770121
doi:

Substances chimiques

Heterochromatin 0
Histones 0
Fungal Proteins 0
Histone Deacetylases EC 3.5.1.98

Types de publication

Journal Article

Langues

eng

Sous-ensembles de citation

IM

Pagination

e2404770121

Subventions

Organisme : HHS | NIH | National Institute of General Medical Sciences (NIGMS)
ID : GM127142
Organisme : HHS | NIH | National Institute of General Medical Sciences (NIGMS)
ID : GM093061

Déclaration de conflit d'intérêts

Competing interests statement:The authors declare no competing interest.

Auteurs

Colleen C Mumford (CC)

Institute of Molecular Biology, University of Oregon, Eugene, OR 97403.
ORCID: 0000-0003-0213-0901

Hideki Tanizawa (H)

Institute of Molecular Biology, University of Oregon, Eugene, OR 97403.
ORCID: 0000-0002-2573-2473

Elizabeth T Wiles (ET)

Institute of Molecular Biology, University of Oregon, Eugene, OR 97403.
ORCID: 0000-0001-7269-7466

Kevin J McNaught (KJ)

Institute of Molecular Biology, University of Oregon, Eugene, OR 97403.
ORCID: 0000-0002-6887-3161

Kirsty Jamieson (K)

Institute of Molecular Biology, University of Oregon, Eugene, OR 97403.

Kenta Tsukamoto (K)

Institute of Molecular Biology, University of Oregon, Eugene, OR 97403.

Eric U Selker (EU)

Institute of Molecular Biology, University of Oregon, Eugene, OR 97403.
ORCID: 0000-0001-6465-0094

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Classifications MeSH

questionsmedicales.fr › Eucaryotes › Champignons › Ascomycota › Sordariales › Neurospora › Neurospora crassa › The RPD3L deacetylation complex is required...
questionsmedicales.fr › Phénomènes génétiques › Structures génétiques › Structures de chromosome › Chromatine › Hétérochromatine › The RPD3L deacetylation complex is required...
questionsmedicales.fr › Acides aminés, peptides et protéines › Protéines › Nucléoprotéines › Histone › The RPD3L deacetylation complex is required...
questionsmedicales.fr › Phénomènes génétiques › Régulation de l'expression des gènes › Régulation de l'expression des gènes fongiques › The RPD3L deacetylation complex is required...
questionsmedicales.fr › Acides aminés, peptides et protéines › Protéines › Protéines fongiques › The RPD3L deacetylation complex is required...
questionsmedicales.fr › Métabolisme › Acylation › Acétylation › The RPD3L deacetylation complex is required...
questionsmedicales.fr › Phénomènes génétiques › Régulation de l'expression des gènes › Épigenèse génétique › Extinction de l'expression des gènes › The RPD3L deacetylation complex is required...
questionsmedicales.fr › Métabolisme › Alkylation › Méthylation › The RPD3L deacetylation complex is required...
questionsmedicales.fr › Enzymes et coenzymes › Enzymes › Hydrolases › Amidohydrolases › Histone deacetylases › The RPD3L deacetylation complex is required...