Neonatal Encephalopathy is a Complex Phenotype Representing Reproductive and Pregnancy Exposome Effects on the Maternal-Placental-Fetal Triad.
Gene-environment interactions
Hypoxic-ischemic encephalopathy
Maternal-placental-fetal triad
Neonatal encephalopathy
Neural exposome
Placental disease
Social determinants of health
Journal
Clinics in perinatology
ISSN: 1557-9840
Titre abrégé: Clin Perinatol
Pays: United States
ID NLM: 7501306
Informations de publication
Date de publication:
Sep 2024
Sep 2024
Historique:
medline:
3
8
2024
pubmed:
3
8
2024
entrez:
2
8
2024
Statut:
ppublish
Résumé
Reproductive, pregnancy, and placental exposomes influence the fetal neural exposome through toxic stressor interplay, impairing the maternal-placental-fetal (MPF) triad. Neonatal encephalopathy represents different clinical presentations based on complex time-dependent etiopathogenetic mechanisms including hypoxia-ischemia that challenge diagnosis and prognosis. Reproductive, pregnancy, and placental exposomes impair the fetal neural exposome through toxic stressor interplay within the MPF triad. Long intervals often separate disease onset from phenotype. Interdisciplinary fetal-neonatal neurology training, practice, and research closes this knowledge gap. Maintaining reproductive health preserves MPF triad health with life-course benefits.
Identifiants
pubmed: 39095094
pii: S0095-5108(24)00040-X
doi: 10.1016/j.clp.2024.04.001
pii:
doi:
Types de publication
Journal Article
Review
Langues
eng
Sous-ensembles de citation
IM
Pagination
535-550Informations de copyright
Copyright © 2024 Elsevier Inc. All rights reserved.
Déclaration de conflit d'intérêts
Disclosure There are no commercial or financial conflicts and no funding sources to disclose.