Uncovering the Role of Inflammation with Asphyxia in the Newborn.

Humans Infant, Newborn Asphyxia Neonatorum / immunology Hypoxia-Ischemia, Brain / therapy Hypothermia, Induced / methods Inflammation / immunology Animals Anti-Inflammatory Agents / therapeutic use
Anti-inflammatory treatments Hypoxia-ischemia Inflammation

Journal

Clinics in perinatology
ISSN: 1557-9840
Titre abrégé: Clin Perinatol
Pays: United States
ID NLM: 7501306

Informations de publication

Date de publication:
Sep 2024
Historique:
medline: 3 8 2024
pubmed: 3 8 2024
entrez: 2 8 2024
Statut: ppublish

Résumé

The etiology of perinatal brain injury is multifactorial, but exposure to perinatal hypoxiaischemia (HI) is a major underlying factor. This review discusses the role of exposure to infection/inflammation in the evolution of HI brain injury, changes in immune responsiveness to subsequent inflammatory challenges after HI and modulation of neural outcomes with interaction between perinatal HI and inflammatory insults. The authors critically assess the clinical and preclinical evidence for the neuroprotective efficacy of therapeutic hypothermia and other anti-inflammatory treatments for inflammation-sensitized HI injury.

Identifiants

DOI: 10.1016/j.clp.2024.04.012 PMID: 39095095
pubmed: 39095095
pii: S0095-5108(24)00051-4
doi: 10.1016/j.clp.2024.04.012
pii:
doi:

Substances chimiques

Anti-Inflammatory Agents 0

Types de publication

Journal Article Review

Langues

eng

Sous-ensembles de citation

IM

Pagination

551-564

Informations de copyright

Copyright © 2024 Elsevier Inc. All rights reserved.

Déclaration de conflit d'intérêts

Disclosure The authors have nothing to disclose.

Auteurs

Simerdeep K Dhillon (SK)

Department of Physiology, The University of Auckland, 85 Park Road, Grafton, Auckland 1023, New Zealand.

Pierre Gressens (P)

Université Paris Cité, NeuroDiderot, Inserm, F-75019 Paris, France.

John Barks (J)

Department of Pediatrics and Communicable Diseases, The University of Michigan, 2018 MLB, Ann Arbor, MI 48109, USA.

Alistair J Gunn (AJ)

Department of Physiology, The University of Auckland, 85 Park Road, Grafton, Auckland 1023, New Zealand. Electronic address: aj.gunn@auckland.ac.nz.

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Classifications MeSH

questionsmedicales.fr › Eucaryotes › Animaux › Chordés › Vertébrés › Mammifères › Eutheria › Primates › Haplorhini › Catarrhini › Hominidae › Humains › Uncovering the Role of Inflammation with...
questionsmedicales.fr › Personnes › Tranches d'âge › Nourrisson › Nouveau-né › Uncovering the Role of Inflammation with...
questionsmedicales.fr › Malformations et maladies congénitales, héréditaires et néonatales › Maladies néonatales › Asphyxie néonatale › Uncovering the Role of Inflammation with...
questionsmedicales.fr › États, signes et symptômes pathologiques › Signes et symptômes › Signes et symptômes respiratoires › Hypoxie › Hypoxie cérébrale › Hypoxie-ischémie du cerveau › Uncovering the Role of Inflammation with...
questionsmedicales.fr › Thérapeutique › Cryothérapie › Hypothermie provoquée › Uncovering the Role of Inflammation with...
questionsmedicales.fr › États, signes et symptômes pathologiques › Processus pathologiques › Inflammation › Uncovering the Role of Inflammation with...
questionsmedicales.fr › Eucaryotes › Animaux › Uncovering the Role of Inflammation with...
questionsmedicales.fr › Actions chimiques et utilisations › Actions pharmacologiques › Utilisations thérapeutiques › Anti-inflammatoires › Uncovering the Role of Inflammation with...