Isolation and Quantification of Palmatine from

Hypoglycemic Agents / pharmacology Antioxidants / pharmacology Molecular Docking Simulation Berberine Alkaloids / pharmacology Plant Extracts / pharmacology Chromatography, High Pressure Liquid Biphenyl Compounds / antagonists & inhibitors Picrates / antagonists & inhibitors Computer Simulation alpha-Glucosidases / metabolism Structure-Activity Relationship
Fibraurea tinctoria Lour antidiabetic antioxidant berberine palmatine

Journal

Drug design, development and therapy
ISSN: 1177-8881
Titre abrégé: Drug Des Devel Ther
Pays: New Zealand
ID NLM: 101475745

Informations de publication

Date de publication:
2024
Historique:
received: 29 12 2023
accepted: 10 07 2024
medline: 7 8 2024
pubmed: 7 8 2024
entrez: 7 8 2024
Statut: epublish

Résumé

This study aimed to isolate and characterize palmatine from Palmatine was isolated from the methanol extract of The isolated compound was identified as palmatine. Quantification of palmatine compound by HPLC showed that palmatine was found in the extract and all fractions. In the in vitro antioxidant activity test using the DPPH method, fraction 4 showed the highest activity, with an IC These results showed that

Identifiants

DOI: 10.2147/DDDT.S454091 PMID: 39109327 PMC: PMC11302523
pubmed: 39109327
doi: 10.2147/DDDT.S454091
pii: 454091
pmc: PMC11302523
doi:

Substances chimiques

Hypoglycemic Agents 0
palmatine G50C034217
Antioxidants 0
Berberine Alkaloids 0
Plant Extracts 0
Biphenyl Compounds 0
Picrates 0
1,1-diphenyl-2-picrylhydrazyl DFD3H4VGDH
alpha-Glucosidases EC 3.2.1.20

Types de publication

Journal Article

Langues

eng

Sous-ensembles de citation

IM

Pagination

3443-3459

Informations de copyright

© 2024 Purwaningsih et al.

Déclaration de conflit d'intérêts

The authors report no conflicts of interest in this work.

Auteurs

Indah Purwaningsih (I)

Department of Chemistry, Faculty of Mathematics and Natural Science, Universitas Padjadjaran, Sumedang, 45363, Indonesia.
Department of Medical Laboratory Technology, Poltekkes Kemenkes Pontianak, Pontianak, 78124, Indonesia.
ORCID: 0000-0003-1800-7000

Iman Permana Maksum (IP)

Department of Chemistry, Faculty of Mathematics and Natural Science, Universitas Padjadjaran, Sumedang, 45363, Indonesia.

Dadan Sumiarsa (D)

Department of Chemistry, Faculty of Mathematics and Natural Science, Universitas Padjadjaran, Sumedang, 45363, Indonesia.

Sriwidodo Sriwidodo (S)

Department of Pharmaceutics and Pharmaceutical Technology, Faculty of Pharmacy, Universitas Padjadjaran, Sumedang, 45363, Indonesia.
ORCID: 0000-0003-3049-8375

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Classifications MeSH

questionsmedicales.fr › Actions chimiques et utilisations › Actions pharmacologiques › Effets physiologiques des médicaments › Hypoglycémiants › Isolation and Quantification of Palmatine from
questionsmedicales.fr › Actions chimiques et utilisations › Utilisations spécialisées de produits chimiques › Agents protecteurs › Antioxydants › Isolation and Quantification of Palmatine from
questionsmedicales.fr › Sciences de l'information › Méthodologies informatiques › Simulation numérique › Simulation de docking moléculaire › Isolation and Quantification of Palmatine from
questionsmedicales.fr › Composés hétérocycliques › Composés hétérocycliques à cycles fusionnés › Composés hétérocycliques avec 4 noyaux ou plus › Alcaloïdes de type berbérine › Isolation and Quantification of Palmatine from
questionsmedicales.fr › Préparations pharmaceutiques › Extraits de plantes › Isolation and Quantification of Palmatine from
questionsmedicales.fr › Techniques d'investigation › Techniques de chimie analytique › Chromatographie › Chromatographie en phase liquide › Chromatographie en phase liquide à haute performance › Isolation and Quantification of Palmatine from
questionsmedicales.fr › Composés chimiques organiques › Hydrocarbures › Hydrocarbures cycliques › Hydrocarbures aromatiques › Dérivés du benzène › Dérivés du biphényle › Isolation and Quantification of Palmatine from
questionsmedicales.fr › Composés chimiques organiques › Composés nitrés › Nitrophénols › Picrates › Isolation and Quantification of Palmatine from
questionsmedicales.fr › Sciences de l'information › Méthodologies informatiques › Simulation numérique › Isolation and Quantification of Palmatine from
questionsmedicales.fr › Enzymes et coenzymes › Enzymes › Hydrolases › Glycosidases › Glucosidases › alpha-Glucosidase › Isolation and Quantification of Palmatine from
questionsmedicales.fr › Phénomènes physiologiques › Phénomènes pharmacologiques et toxicologiques › Phénomènes pharmacologiques › Relation structure-activité › Isolation and Quantification of Palmatine from