Cell factories for biosynthesis of D-glucaric acid: a fusion of static and dynamic strategies.
Cell factory
D-glucaric acid
Dynamic control
Metabolic engineering
Journal
World journal of microbiology & biotechnology
ISSN: 1573-0972
Titre abrégé: World J Microbiol Biotechnol
Pays: Germany
ID NLM: 9012472
Informations de publication
Date de publication:
08 Aug 2024
08 Aug 2024
Historique:
received:
14
06
2024
accepted:
26
07
2024
medline:
8
8
2024
pubmed:
8
8
2024
entrez:
7
8
2024
Statut:
epublish
Résumé
D-glucaric acid is an important organic acid with numerous applications in therapy, food, and materials, contributing significantly to its substantial market value. The biosynthesis of D-glucaric acid (GA) from renewable sources such as glucose has garnered significant attention due to its potential for sustainable and cost-effective production. This review summarizes the current understanding of the cell factories for GA production in different chassis strains, from static to dynamic control strategies for regulating their metabolic networks. We highlight recent advances in the optimization of D-glucaric acid biosynthesis, including metabolic dynamic control, alternative feedstocks, metabolic compartments, and so on. Additionally, we compare the differences between different chassis strains and discuss the challenges that each chassis strain must overcome to achieve highly efficient GA productions. In this review, the processes of engineering a desirable cell factory for highly efficient GA production are just like an epitome of metabolic engineering of strains for chemical biosynthesis, inferring general trends for industrial chassis strain developments.
Identifiants
pubmed: 39112688
doi: 10.1007/s11274-024-04097-6
pii: 10.1007/s11274-024-04097-6
doi:
Substances chimiques
Glucaric Acid
QLZ991V4A2
Glucose
IY9XDZ35W2
Types de publication
Journal Article
Review
Langues
eng
Sous-ensembles de citation
IM
Pagination
292Subventions
Organisme : National Natural Science Foundation of China
ID : 32101170
Organisme : National Natural Science Foundation of China
ID : 32101170
Organisme : National Natural Science Foundation of China
ID : 32101170
Organisme : National Natural Science Foundation of China
ID : 32101170
Organisme : National Natural Science Foundation of China
ID : 32101170
Organisme : National Natural Science Foundation of China
ID : 32101170
Organisme : Natural Science Foundation of Zhejiang Province
ID : LQ22C010001
Organisme : Natural Science Foundation of Zhejiang Province
ID : LQ22C010001
Organisme : Natural Science Foundation of Zhejiang Province
ID : LQ22C010001
Organisme : Natural Science Foundation of Zhejiang Province
ID : LQ22C010001
Organisme : Natural Science Foundation of Zhejiang Province
ID : LQ22C010001
Organisme : Natural Science Foundation of Zhejiang Province
ID : LQ22C010001
Informations de copyright
© 2024. The Author(s), under exclusive licence to Springer Nature B.V.
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