Design of new α-glucosidase inhibitors based on the bis-4-hydroxycoumarin skeleton: Synthesis, evaluation, and in silico studies.
1,2,3-Triazole-N-Phenylacetamide
Bis-4-Hydroxycoumarin
Molecular docking
α-Glucosidase
Journal
Scientific reports
ISSN: 2045-2322
Titre abrégé: Sci Rep
Pays: England
ID NLM: 101563288
Informations de publication
Date de publication:
12 Aug 2024
12 Aug 2024
Historique:
received:
30
03
2024
accepted:
06
08
2024
medline:
13
8
2024
pubmed:
13
8
2024
entrez:
12
8
2024
Statut:
epublish
Résumé
In this work, we have reported the design, synthesis, in vitro, and in silico enzymatic evaluation of new bis-4-hydroxycoumarin-based phenoxy-1,2,3-triazole-N-phenylacetamide derivatives 5a-m as potent α-glucosidase inhibitors. All the synthesized analogues showed high inhibition effects against α-glucosidase (IC
Identifiants
pubmed: 39134641
doi: 10.1038/s41598-024-69592-0
pii: 10.1038/s41598-024-69592-0
doi:
Substances chimiques
Glycoside Hydrolase Inhibitors
0
alpha-Glucosidases
EC 3.2.1.20
4-Hydroxycoumarins
0
4-hydroxycoumarin
X954ZLL2RD
Types de publication
Journal Article
Langues
eng
Sous-ensembles de citation
IM
Pagination
18693Informations de copyright
© 2024. The Author(s).
Références
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