Sweat lactate sensor for detecting anaerobic threshold in heart failure: a prospective clinical trial (LacS-001).

Humans Heart Failure / metabolism Sweat / metabolism Male Female Aged Middle Aged Anaerobic Threshold Lactic Acid / metabolism Prospective Studies Exercise Test / methods

Anaerobic threshold Heart failure Sweat lactate sensor Ventilatory threshold

Journal

Scientific reports

ISSN: 2045-2322

Titre abrégé: Sci Rep

Pays: England

ID NLM: 101563288

Informations de publication

Date de publication:
16 Aug 2024

Historique:

received: 15 09 2023

accepted: 12 08 2024

medline: 17 8 2024

pubmed: 17 8 2024

entrez: 16 8 2024

Statut: epublish

Résumé

A simple method for determining the anaerobic threshold in patients with heart failure (HF) is needed. This prospective clinical trial (LacS-001) aimed to investigate the safety of a sweat lactate-monitoring sensor and the correlation between lactate threshold in sweat (sLT) and ventilatory threshold (VT). To this end, we recruited 50 patients with HF and New York Heart Association functional classification I-II (mean age: 63.5 years, interquartile range: 58.0-72.0). Incremental exercise tests were conducted while monitoring sweat lactate levels using our sensor. sLT was defined as the first steep increase in lactate levels from baseline. Primary outcome measures were a correlation coefficient of ≥ 0.6 between sLT and VT, similarities as assessed by the Bland-Altman analysis, and standard deviation of the difference within 15 W. A correlation coefficient of 0.651 (95% confidence interval, 0.391-0.815) was achieved in 32/50 cases. The difference between sLT and VT was -4.9 ± 15.0 W. No comparative error was noted in the Bland-Altman plot. No device-related adverse events were reported among the registered patients. Our sweat lactate sensor is safe and accurate for detecting VT in patients with HF in clinical settings, thereby offering valuable additional information for treatment.

Identifiants

DOI: 10.1038/s41598-024-70001-9 PMID: 39152287

pubmed: 39152287

doi: 10.1038/s41598-024-70001-9

pii: 10.1038/s41598-024-70001-9

doi:

Substances chimiques

Lactic Acid 33X04XA5AT

Types de publication

Journal Article Clinical Trial

Langues

eng

Sous-ensembles de citation

Pagination

18985

Subventions

Organisme : Japan Science and Technology Corporation

ID : JPMJPF2101

Informations de copyright

Références

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