Dynamic cytokine profiles of bloodstream infection caused by Klebsiella pneumoniae in China.
Humans
Klebsiella pneumoniae
/ drug effects
Klebsiella Infections
/ mortality
Male
Female
Cytokines
/ blood
Middle Aged
China
/ epidemiology
Anti-Bacterial Agents
/ pharmacology
Aged
Microbial Sensitivity Tests
Bacteremia
/ microbiology
Interleukin-10
/ blood
Adult
Interleukin-6
/ blood
Risk Factors
Tumor Necrosis Factor-alpha
/ blood
Arginase
/ blood
Sepsis
/ microbiology
Interferon-gamma
/ blood
Klebsiella pneumoniae
Arginase
IL-10
IL-6
Mortality
Journal
Annals of clinical microbiology and antimicrobials
ISSN: 1476-0711
Titre abrégé: Ann Clin Microbiol Antimicrob
Pays: England
ID NLM: 101152152
Informations de publication
Date de publication:
24 Aug 2024
24 Aug 2024
Historique:
received:
03
12
2023
accepted:
13
08
2024
medline:
26
8
2024
pubmed:
26
8
2024
entrez:
24
8
2024
Statut:
epublish
Résumé
The aim of this work was to assess dynamic cytokine profiles associated with bloodstream infection (BSI) caused by Klebsiella pneumoniae (Kpn) and investigate the clinical features associated with mortality. A total of 114 patients with positive BSI-Kpn and 12 sepsis individuals without blood positive bacteria culture were followed up. Cytokine profiles were analyzed by multiplex immunoassay on the first, third, seventh and fourteenth day after diagnosis. The test cytokines included arginase, interferon-gamma (IFN-γ), tumor necrosis factor alpha (TNF-α), interleukin (IL)-1β, IL-4, IL-6, IL-10, IL-12 (p70), and IL-23. The minimum inhibitory concentration (MIC) of 24 antibiotics were tested for BSI-Kpn. Risk factors associated with the 30-day mortality and 120-day mortality were evaluated using logistic analyses and nomogram. There were 55 out of 114 patients with BSI-Kpn were included. All isolates showed high susceptibility rate to novel avibactam combinations. The level of arginase was the highest in carbapenem-resistant Kpn (CRKP) patients. The AUCs of arginase, TNF-α and IL-4 reached 0.726, 0.495, and 0.549, respectively, whereas the AUC for the combination of these three cytokines was 0.805. Notably, 120-day mortality in patients with CRKP was higher than carbapenem-sensitive K. pneumoniae (CSKP). Furthermore, the long-term and high levels of IL-6 and IL-10 were associated with death. High expression of arginase is correlated with CRKP. In addition, BSI-CRKP could result in indolent clinic course but poor long-term prognosis. Continuous increase of IL-6 and IL-10 were associated with mortality.
Identifiants
pubmed: 39182143
doi: 10.1186/s12941-024-00739-7
pii: 10.1186/s12941-024-00739-7
doi:
Substances chimiques
Cytokines
0
Anti-Bacterial Agents
0
Interleukin-10
130068-27-8
Interleukin-6
0
Tumor Necrosis Factor-alpha
0
Arginase
EC 3.5.3.1
Interferon-gamma
82115-62-6
Types de publication
Journal Article
Langues
eng
Sous-ensembles de citation
IM
Pagination
79Informations de copyright
© 2024. The Author(s).
Références
Wang M, Earley M, Chen L, Hanson BM, Yu Y, Liu Z, Salcedo S, Cober E, Li L, Kanj SS, Gao H, Munita JM, Ordoñez K, Weston G, Satlin MJ, Valderrama-Beltrán SL, Marimuthu K, Stryjewski ME, Komarow L, Luterbach C, Marshall SH, Rudin SD, Manca C, Paterson DL, Reyes J, Villegas MV, Evans S, Hill C, Arias R, Baum K, Fries BC, Doi Y, Patel R, Kreiswirth BN, Bonomo RA, Chambers HF, Fowler VG Jr, Arias CA, van Duin D. Multi-drug Resistant Organism Network investigators. Clinical outcomes and bacterial characteristics of carbapenem-resistant Klebsiella pneumoniae complex among patients from different global regions (CRACKLE-2): a prospective, multicentre, cohort study. Lancet Infect Dis. 2022;22(3):401–12. https://doi.org/10.1016/S1473-3099(21)00399-6 .
doi: 10.1016/S1473-3099(21)00399-6
pubmed: 34767753
Zhang Y, Wang Q, Yin Y, Chen H, Jin L, Gu B, Xie L, Yang C, Ma X, Li H, Li W, Zhang X, Liao K, Man S, Wang S, Wen H, Li B, Guo Z, Tian J, Pei F, Liu L, Zhang L, Zou C, Hu T, Cai J, Yang H, Huang J, Jia X, Huang W, Cao B, Wang H. Epidemiology of Carbapenem-Resistant Enterobacteriaceae infections: Report from the China CRE Network. Antimicrob Agents Chemother. 2018;62(2):e01882–17. https://doi.org/10.1128/AAC.01882-17 .
doi: 10.1128/AAC.01882-17
pubmed: 29203488
pmcid: 5786810
Chen Y, Ji J, Ying C, Liu Z, Yang Q, Kong H, Xiao Y, Blood Bacterial Resistant Investigation Collaborative System (BRICS) Study Group. Blood bacterial resistant investigation collaborative system (BRICS) report: a national surveillance in China from 2014 to 2019. Antimicrob Resist Infect Control. 2022;11(1):17. https://doi.org/10.1186/s13756-022-01055-5 .
doi: 10.1186/s13756-022-01055-5
pubmed: 35074014
pmcid: 8785473
Chen Y, Ying S, Jiang L, Dong S, Dai J, Jin X, Yu W, Qiu Y. A Novel Nomogram for Predicting Risk factors and outcomes in Bloodstream infections caused by Klebsiella pneumoniae. Infect Drug Resist. 2022;15:1317–28. https://doi.org/10.2147/IDR.S349236 .
doi: 10.2147/IDR.S349236
pubmed: 35378894
pmcid: 8976504
Onorato L, Sarnelli B, D’Agostino F, Signoriello G, Trama U, D’Argenzio A, Montemurro MV, Coppola N. Epidemiological, clinical and microbiological characteristics of patients with bloodstream infections due to Carbapenem-Resistant K. Pneumoniae in Southern Italy: a Multicentre Study. Antibiot (Basel). 2022;11(5):633. https://doi.org/10.3390/antibiotics11050633 .
doi: 10.3390/antibiotics11050633
Sabino S, Soares S, Ramos F, Moretti M, Zavascki AP, Rigatto MH. A cohort study of the impact of Carbapenem-Resistant Enterobacteriaceae infections on Mortality of patients presenting with Sepsis. mSphere. 2019;4(2):e00052–19. https://doi.org/10.1128/mSphere.00052-19.] .
doi: 10.1128/mSphere.00052-19.]
pubmed: 30971443
pmcid: 6458433
Wong Fok Lung T, Charytonowicz D, Beaumont KG, Shah SS, Sridhar SH, Gorrie CL, Mu A, Hofstaedter CE, Varisco D, McConville TH, Drikic M, Fowler B, Urso A, Shi W, Fucich D, Annavajhala MK, Khan IN, Oussenko I, Francoeur N, Smith ML, Stockwell BR, Lewis IA, Hachani A, Upadhyay Baskota S, Uhlemann AC, Ahn D, Ernst RK, Howden BP, Sebra R, Prince A. Klebsiella pneumoniae induces host metabolic stress that promotes tolerance to pulmonary infection. Cell Metab. 2022;34(5):761–e7749. https://doi.org/10.1016/j.cmet.2022.03.009 .
doi: 10.1016/j.cmet.2022.03.009
pubmed: 35413274
pmcid: 9081115
Feriotti C, Sá-Pessoa J, Calderón-González R, Gu L, Morris B, Sugisawa R, Insua JL, Carty M, Dumigan A, Ingram RJ, Kissenpfening A, Bowie AG, Bengoechea JA. Klebsiella pneumoniae hijacks the Toll-IL-1R protein SARM1 in a type I IFN-dependent manner to antagonize host immunity. Cell Rep. 2022;40(6):111167. https://doi.org/10.1016/j.celrep.2022.111167 .
doi: 10.1016/j.celrep.2022.111167
pubmed: 35947948
pmcid: 9638020
Martynova E, Rizvanov A, Urbanowicz RA, Khaiboullina S. Inflammasome Contribution to the activation of Th1, Th2, and Th17 Immune responses. Front Microbiol. 2022;13:851835. https://doi.org/10.3389/fmicb.2022.851835 .
doi: 10.3389/fmicb.2022.851835
pubmed: 35369454
pmcid: 8969514
Olonisakin TF, Li H, Xiong Z, Kochman EJ, Yu M, Qu Y, Hulver M, Kolls JK, St Croix C, Doi Y, Nguyen MH, Shanks RM, Mallampalli RK, Kagan VE, Ray A, Silverstein RL, Ray P, Lee JS. CD36 provides host Protection Against Klebsiella pneumoniae Intrapulmonary infection by enhancing Lipopolysaccharide responsiveness and Macrophage Phagocytosis. J Infect Dis. 2016;214(12):1865–75. https://doi.org/10.1093/infdis/jiw451 .
doi: 10.1093/infdis/jiw451
pubmed: 27683817
pmcid: 5142085
Happel KI, Dubin PJ, Zheng M, Ghilardi N, Lockhart C, Quinton LJ, Odden AR, Shellito JE, Bagby GJ, Nelson S, Kolls JK. Divergent roles of IL-23 and IL-12 in host defense against Klebsiella pneumoniae. J Exp Med. 2005;202(6):761–9. https://doi.org/10.1084/jem.20050193 .
doi: 10.1084/jem.20050193
pubmed: 16157683
pmcid: 2212952
Yu W, Luo Q, Shen P, Chen Y, Xu H, Xiao Y, Qiu Y. New options for bloodstream infections caused by colistin- or ceftazidime/avibactam-resistant Klebsiella pneumoniae. Int J Antimicrob Agents. 2021;58(6):106458. https://doi.org/10.1016/j.ijantimicag.2021.106458 .
doi: 10.1016/j.ijantimicag.2021.106458
pubmed: 34706255
Clinical and Laboratory Standards Institute. Performance standards for antimicrobial susceptibility testing. 32th informational supplement 2022. http://www.clsi.org/ . Accessed February 2022.
Chen C, Chen H, Zhang Y, Thomas HR, Frank MH, He Y, Xia R. TBtools: an integrative Toolkit developed for interactive analyses of big Biological Data. Mol Plant. 2020;13(8):1194–202. https://doi.org/10.1016/j.molp.2020.06.009 .
doi: 10.1016/j.molp.2020.06.009
pubmed: 32585190
Pan H, Lou Y, Zeng L, Wang L, Zhang J, Yu W, Qiu Y. Infections caused by carbapenemase-producing Klebsiella pneumoniae: microbiological characteristics and risk factors. Microb Drug Resist. 2019;25(2):287–96. https://doi.org/10.1089/mdr.2018.0339 .
doi: 10.1089/mdr.2018.0339
pubmed: 30810470
pmcid: 6441289
Papp-Wallace KM. The latest advances in β-lactam/β-lactamase inhibitor combinations for the treatment of Gram-negative bacterial infections. Expert Opin Pharmacother. 2019;20(17):2169–84. https://doi.org/10.1080/14656566.2019.1660772 .
doi: 10.1080/14656566.2019.1660772
pubmed: 31500471
pmcid: 6834881
Bengoechea JA, Sa Pessoa J. Klebsiella pneumoniae infection biology: living to counteract host defences. FEMS Microbiol Rev. 2019;43(2):123–44. https://doi.org/10.1093/femsre/fuy043 .
doi: 10.1093/femsre/fuy043
pubmed: 30452654
Yu W, Xiong L, Luo Q, Chen Y, Ji J, Ying C, Liu Z, Xiao Y. In Vitro Activity comparison of Ceftazidime-Avibactam and Aztreonam-Avibactam against Bloodstream infections with Carbapenem-resistant organisms in China. Front Cell Infect Microbiol. 2021;11:780365. https://doi.org/10.3389/fcimb.2021.780365 .
doi: 10.3389/fcimb.2021.780365
pubmed: 34900759
pmcid: 8656719
Jarczak D, Nierhaus A. Cytokine Storm-Definition, causes, and implications. Int J Mol Sci. 2022;23(19):11740. https://doi.org/10.3390/ijms231911740 .
doi: 10.3390/ijms231911740
pubmed: 36233040
pmcid: 9570384
Haydar D, Gonzalez R, Garvy BA, Garneau-Tsodikova S, Thamban Chandrika N, Bocklage TJ, Feola DJ. Myeloid arginase-1 controls excessive inflammation and modulates T cell responses in Pseudomonas aeruginosa pneumonia. Immunobiology. 2021;226(1):152034. https://doi.org/10.1016/j.imbio.2020.152034 .
doi: 10.1016/j.imbio.2020.152034
pubmed: 33278710
Dowling JK, Afzal R, Gearing LJ, Cervantes-Silva MP, Annett S, Davis GM, De Santi C, Assmann N, Dettmer K, Gough DJ, Bantug GR, Hamid FI, Nally FK, Duffy CP, Gorman AL, Liddicoat AM, Lavelle EC, Hess C, Oefner PJ, Finlay DK, Davey GP, Robson T, Curtis AM, Hertzog PJ, Williams BRG, McCoy CE. Mitochondrial arginase-2 is essential for IL-10 metabolic reprogramming of inflammatory macrophages. Nat Commun. 2021;12(1):1460. https://doi.org/10.1038/s41467-021-21617-2 .
doi: 10.1038/s41467-021-21617-2
pubmed: 33674584
pmcid: 7936006
Joanna Homa A, Klosowska M, Chadzinska. Arginase Activity in Eisenia andrei Coelomocytes: function in the Earthworm Innate Response. Int J Mol Sci. 2021;22(7):3687. https://doi.org/10.3390/ijms22073687 .
doi: 10.3390/ijms22073687
pubmed: 33916228
pmcid: 8037997
Rhee C, Kadri SS, Dekker JP, Danner RL, Chen HC, Fram D, Zhang F, Wang R, Klompas M, CDC Prevention Epicenters Program. Prevalence of antibiotic-resistant pathogens in Culture-Proven Sepsis and outcomes Associated with inadequate and broad-spectrum empiric antibiotic use. JAMA Netw Open. 2020;3(4):e202899. https://doi.org/10.1001/jamanetworkopen.2020.2899 .
doi: 10.1001/jamanetworkopen.2020.2899
pubmed: 32297949
pmcid: 7163409
van Enckevort FH, Sweep CG, Span PN, Netea MG, Hermus AR, Kullberg BJ. Reduced adrenal response and increased mortality after systemic Klebsiella pneumoniae infection in interleukin-6-deficient mice. Eur Cytokine Netw. 2001;12(4):581–6.
pubmed: 11781184
Dolgachev VA, Yu B, Sun L, Shanley TP, Raghavendran K, Hemmila MR. Interleukin 10 overexpression alters survival in the setting of gram-negative pneumonia following lung contusion. Shock. 2014;41(4):301–10. https://doi.org/10.1097/SHK.0000000000000123 .
doi: 10.1097/SHK.0000000000000123
pubmed: 24430542
pmcid: 4019007