Different Prostatic Tissue Microbiomes between High- and Low-Grade Prostate Cancer Pathogenesis.
Cutibacterium
biomarker
high-grade prostate tumor (HGT)
low-grade prostate tumor (LGT)
prostate cancer
therapeutic targets
Journal
International journal of molecular sciences
ISSN: 1422-0067
Titre abrégé: Int J Mol Sci
Pays: Switzerland
ID NLM: 101092791
Informations de publication
Date de publication:
16 Aug 2024
16 Aug 2024
Historique:
received:
28
06
2024
revised:
10
08
2024
accepted:
14
08
2024
medline:
31
8
2024
pubmed:
31
8
2024
entrez:
29
8
2024
Statut:
epublish
Résumé
Numerous human pathologies, such as neoplasia, are related to particular bacteria and changes in microbiome constituents. To investigate the association between an imbalance of bacteria and prostate carcinoma, the microbiome and gene functionality from tissues of patients with high-grade prostate tumor (HGT) and low-grade prostate tumor (LGT) were compared utilizing next-generation sequencing (NGS) technology. The results showed abnormalities in the bacterial profiles between the HGT and LGT specimens, indicating alterations in the make-up of bacterial populations and gene functionalities. The HGT specimens showed higher frequencies of
Identifiants
pubmed: 39201629
pii: ijms25168943
doi: 10.3390/ijms25168943
pii:
doi:
Types de publication
Journal Article
Langues
eng
Sous-ensembles de citation
IM
Subventions
Organisme : National Research Foundation of Korea
ID : RS-2024-00333544
Organisme : National Research Foundation of Korea
ID : RS-2023-00219563
Organisme : Soonchunhyang University
ID : Soonchunhyang University Research Fund