Concept and location neurons in the human brain provide the 'what' and 'where' in memory formation.
Journal
Nature communications
ISSN: 2041-1723
Titre abrégé: Nat Commun
Pays: England
ID NLM: 101528555
Informations de publication
Date de publication:
10 Sep 2024
10 Sep 2024
Historique:
received:
08
06
2021
accepted:
29
08
2024
medline:
11
9
2024
pubmed:
11
9
2024
entrez:
10
9
2024
Statut:
epublish
Résumé
Our brains create new memories by capturing the 'who/what', 'where' and 'when' of everyday experiences. On a neuronal level, mechanisms facilitating a successful transfer into episodic memory are still unclear. We investigated this by measuring single neuron activity in the human medial temporal lobe during encoding of item-location associations. While previous research has found predictive effects in population activity in human MTL structures, we could attribute such effects to two specialized sub-groups of neurons: concept cells in the hippocampus, amygdala and entorhinal cortex (EC), and a second group of parahippocampal location-selective neurons. In both item- and location-selective populations, firing rates were significantly higher during successfully encoded trials. These findings are in line with theories of hippocampal indexing, since selective index neurons may act as pointers to neocortical representations. Overall, activation of distinct populations of neurons could directly support the connection of the 'what' and 'where' of episodic memory.
Identifiants
pubmed: 39256373
doi: 10.1038/s41467-024-52295-5
pii: 10.1038/s41467-024-52295-5
doi:
Types de publication
Journal Article
Langues
eng
Sous-ensembles de citation
IM
Pagination
7926Subventions
Organisme : Deutsche Forschungsgemeinschaft (German Research Foundation)
ID : Mo930/4-2, SPP2205, SPP2411, SFB1089
Organisme : Volkswagen Foundation (VolkswagenStiftung)
ID : 86 507
Organisme : Bundesministerium für Bildung und Forschung (Federal Ministry of Education and Research)
ID : 031L0197B
Organisme : Ministerium für Innovation, Wissenschaft und Forschung des Landes Nordrhein-Westfalen (MIWF-NRW)
ID : iBehave
Informations de copyright
© 2024. The Author(s).
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