Netrin-1-CD146 and netrin-1-S100A9 are associated with early stage of lymph node metastasis in colorectal cancer.
CD146
Colorectal cancer
Lymph node metastasis
Netrin-1
S100 proteins
Journal
BMC gastroenterology
ISSN: 1471-230X
Titre abrégé: BMC Gastroenterol
Pays: England
ID NLM: 100968547
Informations de publication
Date de publication:
11 Sep 2024
11 Sep 2024
Historique:
received:
27
03
2024
accepted:
03
09
2024
medline:
12
9
2024
pubmed:
12
9
2024
entrez:
11
9
2024
Statut:
epublish
Résumé
The netrin-1/CD146 pathway regulates colorectal cancer (CRC) liver metastasis, angiogenesis, and vascular development. However, few investigations have yet examined the biological function of netrin-1/CD146 complex in CRC. In this work, we investigated the relationship between the netrin-1/CD146 axis and S100 proteins in sentinel lymph node, and revealed a possible new clue for vascular metastasis of CRC. The expression levels of netrin-1 and CD146 proteins in CRC, as well as S100A8 and S100A9 proteins in the sentinel lymph nodes were determined by immunohistochemistry. Using GEPIA and UALCAN, we analyzed netrin-1 and CD146 gene expression in CRC, their association with CRC stage, and their expression levels and prognosis in CRC patients. The expression level of netrin-1 in N The netrin-1/CD146 and netrin-1/S100A9 axis in CRC tissues might related with early stage of lymph node metastasis, thus providing potential novel channels for blocking lymphatic metastasis and guiding biomarker discovery in CRC patients.
Sections du résumé
BACKGROUND
BACKGROUND
The netrin-1/CD146 pathway regulates colorectal cancer (CRC) liver metastasis, angiogenesis, and vascular development. However, few investigations have yet examined the biological function of netrin-1/CD146 complex in CRC. In this work, we investigated the relationship between the netrin-1/CD146 axis and S100 proteins in sentinel lymph node, and revealed a possible new clue for vascular metastasis of CRC.
METHODS
METHODS
The expression levels of netrin-1 and CD146 proteins in CRC, as well as S100A8 and S100A9 proteins in the sentinel lymph nodes were determined by immunohistochemistry. Using GEPIA and UALCAN, we analyzed netrin-1 and CD146 gene expression in CRC, their association with CRC stage, and their expression levels and prognosis in CRC patients.
RESULTS
RESULTS
The expression level of netrin-1 in N
CONCLUSIONS
CONCLUSIONS
The netrin-1/CD146 and netrin-1/S100A9 axis in CRC tissues might related with early stage of lymph node metastasis, thus providing potential novel channels for blocking lymphatic metastasis and guiding biomarker discovery in CRC patients.
Identifiants
pubmed: 39261771
doi: 10.1186/s12876-024-03401-w
pii: 10.1186/s12876-024-03401-w
doi:
Substances chimiques
Netrin-1
158651-98-0
CD146 Antigen
0
Calgranulin B
0
S100A9 protein, human
0
NTN1 protein, human
0
Biomarkers, Tumor
0
Calgranulin A
0
Types de publication
Journal Article
Langues
eng
Sous-ensembles de citation
IM
Pagination
308Subventions
Organisme : the Health, Science and Technology Plan Project of Hangzhou
ID : A20200024
Organisme : the Science and Technology Development Plan Project of Hangzhou
ID : 20201203B201
Organisme : the Zhejiang Provincial Natural Science Foundation of China
ID : LGF20H270001
Informations de copyright
© 2024. The Author(s).
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pmcid: 5387898
doi: 10.15537/smj.2017.3.16245