Validation of shikimate dehydrogenase as the herbicidal target of drupacine and screening of target-based compounds with high herbicidal activity.

Alcohol Oxidoreductases / metabolism Herbicides / pharmacology Mutagenesis, Site-Directed
Herbicide Lead compounds Natural product Shikimate dehydrogenase

Journal

Pesticide biochemistry and physiology
ISSN: 1095-9939
Titre abrégé: Pestic Biochem Physiol
Pays: United States
ID NLM: 1301573

Informations de publication

Date de publication:
Sep 2024
Historique:
received: 21 06 2024
revised: 29 07 2024
accepted: 04 08 2024
medline: 15 9 2024
pubmed: 15 9 2024
entrez: 14 9 2024
Statut: ppublish

Résumé

The discovery of new targets and lead compounds is the key to developing new pesticides. The herbicidal target of drupacine has been identified as shikimate dehydrogenase (SkDH). However, the mechanism of interaction between them remains unclear. This study found that drupacine specifically binds to SkDH with a dissociation equilibrium constant (K

Identifiants

DOI: 10.1016/j.pestbp.2024.106077 PMID: 39277390
pubmed: 39277390
pii: S0048-3575(24)00310-9
doi: 10.1016/j.pestbp.2024.106077
pii:
doi:

Substances chimiques

Alcohol Oxidoreductases EC 1.1.-
Herbicides 0
Shikimate dehydrogenase EC 1.1.1.25

Types de publication

Journal Article

Langues

eng

Sous-ensembles de citation

IM

Pagination

106077

Informations de copyright

Copyright © 2024 Elsevier Inc. All rights reserved.

Déclaration de conflit d'intérêts

Declaration of competing interest The authors declare no competing financial interests.

Auteurs

Mingyu Wang (M)

College of Plant Protection, Hebei Agricultural University, Baoding 071000, China.

Lili Dong (L)

College of Plant Protection, Hebei Agricultural University, Baoding 071000, China; Key Laboratory of Hebei Province for Plant Physiology and Molecular Pathology/ State Key Laboratory of North China Crop Improvement and Regulation, Hebei Agricultural University, Baoding 071000, China.

Yuwei Wang (Y)

College of Plant Protection, Hebei Agricultural University, Baoding 071000, China.

Fengyue Suo (F)

College of Plant Protection, Hebei Agricultural University, Baoding 071000, China.

Lihui Zhang (L)

College of Plant Protection, Hebei Agricultural University, Baoding 071000, China; Key Laboratory of Hebei Province for Plant Physiology and Molecular Pathology/ State Key Laboratory of North China Crop Improvement and Regulation, Hebei Agricultural University, Baoding 071000, China. Electronic address: zhanglihui@hebau.edu.cn.

Jingao Dong (J)

College of Plant Protection, Hebei Agricultural University, Baoding 071000, China; Key Laboratory of Hebei Province for Plant Physiology and Molecular Pathology/ State Key Laboratory of North China Crop Improvement and Regulation, Hebei Agricultural University, Baoding 071000, China. Electronic address: dongjingao@126.com.

Shujie Ma (S)

College of Plant Protection, Hebei Agricultural University, Baoding 071000, China; Key Laboratory of Hebei Province for Plant Physiology and Molecular Pathology/ State Key Laboratory of North China Crop Improvement and Regulation, Hebei Agricultural University, Baoding 071000, China. Electronic address: mashujie89@126.com.

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Classifications MeSH

questionsmedicales.fr › Enzymes et coenzymes › Enzymes › Oxidoreductases › Alcohol oxidoreductases › Validation of shikimate dehydrogenase as the...
questionsmedicales.fr › Actions chimiques et utilisations › Actions toxiques › Pesticides › Herbicides › Validation of shikimate dehydrogenase as the...
questionsmedicales.fr › Techniques d'investigation › Techniques génétiques › Génie génétique › Ingénierie des protéines › Mutagenèse dirigée › Validation of shikimate dehydrogenase as the...