Mechanistic analysis of Riboswitch Ligand interactions provides insights into pharmacological control over gene expression.
Journal
Nature communications
ISSN: 2041-1723
Titre abrégé: Nat Commun
Pays: England
ID NLM: 101528555
Informations de publication
Date de publication:
17 Sep 2024
17 Sep 2024
Historique:
received:
26
02
2024
accepted:
28
08
2024
medline:
18
9
2024
pubmed:
18
9
2024
entrez:
17
9
2024
Statut:
epublish
Résumé
Riboswitches are structured RNA elements that regulate gene expression upon binding to small molecule ligands. Understanding the mechanisms by which small molecules impact riboswitch activity is key to developing potent, selective ligands for these and other RNA targets. We report the structure-informed design of chemically diverse synthetic ligands for PreQ
Identifiants
pubmed: 39289353
doi: 10.1038/s41467-024-52235-3
pii: 10.1038/s41467-024-52235-3
doi:
Substances chimiques
Riboswitch
0
Ligands
0
Aptamers, Nucleotide
0
RNA, Bacterial
0
Types de publication
Journal Article
Langues
eng
Sous-ensembles de citation
IM
Pagination
8173Subventions
Organisme : U.S. Department of Health & Human Services | NIH | National Cancer Institute (NCI)
ID : BC011585
Informations de copyright
© 2024. This is a U.S. Government work and not under copyright protection in the US; foreign copyright protection may apply.
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