Structural insights into polyamine spermidine uptake by the ABC transporter PotD-PotABC.

Spermidine / metabolism ATP-Binding Cassette Transporters / metabolism Escherichia coli Proteins / metabolism Escherichia coli / metabolism Biological Transport Models, Molecular Protein Conformation Protein Binding

Journal

Science advances
ISSN: 2375-2548
Titre abrégé: Sci Adv
Pays: United States
ID NLM: 101653440

Informations de publication

Date de publication:
20 Sep 2024
Historique:
medline: 20 9 2024
pubmed: 20 9 2024
entrez: 20 9 2024
Statut: ppublish

Résumé

Polyamines, characterized by their polycationic nature, are ubiquitously present in all organisms and play numerous cellular functions. Among polyamines, spermidine stands out as the predominant type in both prokaryotic and eukaryotic cells. The PotD-PotABC protein complex in

Identifiants

DOI: 10.1126/sciadv.ado8107 PMID: 39303029
pubmed: 39303029
doi: 10.1126/sciadv.ado8107
doi:

Substances chimiques

Spermidine U87FK77H25
ATP-Binding Cassette Transporters 0
Escherichia coli Proteins 0

Types de publication

Journal Article

Langues

eng

Sous-ensembles de citation

IM

Pagination

eado8107

Auteurs

Zhu Qiao (Z)

School of Biological Sciences, Nanyang Technological University, Singapore 637551, Singapore.
NTU Institute of Structural Biology, Nanyang Technological University, Singapore 636921, Singapore.
ORCID: 0000-0002-1828-7658

Phong Hoa Do (PH)

School of Biological Sciences, Nanyang Technological University, Singapore 637551, Singapore.
NTU Institute of Structural Biology, Nanyang Technological University, Singapore 636921, Singapore.

Joshua Yi Yeo (JY)

School of Biological Sciences, Nanyang Technological University, Singapore 637551, Singapore.
NTU Institute of Structural Biology, Nanyang Technological University, Singapore 636921, Singapore.
ORCID: 0000-0002-0253-0238

Rya Ero (R)

School of Biological Sciences, Nanyang Technological University, Singapore 637551, Singapore.
NTU Institute of Structural Biology, Nanyang Technological University, Singapore 636921, Singapore.
ORCID: 0000-0001-5691-9188

Zhuowen Li (Z)

School of Biological Sciences, Nanyang Technological University, Singapore 637551, Singapore.
ORCID: 0000-0002-1845-5586

Liying Zhan (L)

Department of Critical Care Medicine, Renmin Hospital of Wuhan University, Wuhan 430060, China.
ORCID: 0000-0003-1667-0570

Sandip Basak (S)

School of Biological Sciences, Nanyang Technological University, Singapore 637551, Singapore.
NTU Institute of Structural Biology, Nanyang Technological University, Singapore 636921, Singapore.

Yong-Gui Gao (YG)

School of Biological Sciences, Nanyang Technological University, Singapore 637551, Singapore.
NTU Institute of Structural Biology, Nanyang Technological University, Singapore 636921, Singapore.
ORCID: 0000-0001-7298-0835

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Classifications MeSH

questionsmedicales.fr › Composés chimiques organiques › Amines › Polyamines › Spermidine › Structural insights into polyamine spermidine...
questionsmedicales.fr › Acides aminés, peptides et protéines › Protéines › Protéines membranaires › Protéines de transport membranaire › Transporteurs ABC › Structural insights into polyamine spermidine...
questionsmedicales.fr › Acides aminés, peptides et protéines › Protéines › Protéines bactériennes › Protéines Escherichia coli › Structural insights into polyamine spermidine...
questionsmedicales.fr › Bactéries › Proteobacteria › Gammaproteobacteria › Enterobacteriaceae › Escherichia › Escherichia coli › Structural insights into polyamine spermidine...
questionsmedicales.fr › Métabolisme › Transport biologique › Structural insights into polyamine spermidine...
questionsmedicales.fr › Techniques d'investigation › Modèles théoriques › Modèles moléculaires › Structural insights into polyamine spermidine...
questionsmedicales.fr › Phénomènes chimiques › Phénomènes biochimiques › Conformation moléculaire › Conformation des protéines › Structural insights into polyamine spermidine...
questionsmedicales.fr › Métabolisme › Liaison aux protéines › Structural insights into polyamine spermidine...