Divergent autoantibody and cytokine levels in COVID-19 sepsis patients influence survival.
COVID‐19
SARS‐CoV‐2
autoantibodies
cytokines
sepsis
survival
Journal
Journal of medical virology
ISSN: 1096-9071
Titre abrégé: J Med Virol
Pays: United States
ID NLM: 7705876
Informations de publication
Date de publication:
Oct 2024
Oct 2024
Historique:
revised:
20
08
2024
received:
12
03
2024
accepted:
15
09
2024
medline:
26
9
2024
pubmed:
26
9
2024
entrez:
26
9
2024
Statut:
ppublish
Résumé
Studies have pointed to a decisive role of autoantibodies in the context of sepsis and severe Coronavirus disease 2019 (COVID-19), which itself often fulfills the criteria for sepsis, including dysregulated immune responses and organ dysfunction. To directly compare and further analyze the autoantibody profiles of sepsis patients with and without COVID-19, the luciferase immunoprecipitation systems (LIPS) assay was used to measure the levels of autoantibodies against a variety of clinically relevant cytokines, lung-associated proteins, other autoantigens, and antibodies against the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2). In addition, cytokine titers were measured with the LEGENDplex™ Human Antivirus Response Panel. We observed significantly increased levels of autoantibodies in 59% of the COVID-19-Sepsis group compared to 48% of the Sepsis group. Significant differences were identified between the groups for the levels of autoantibodies against gATPase. The cytokine levels of interferon (IFN)-λ1 and IP-10 were higher in the COVID-19-Sepsis group compared to the Sepsis group. Additional correlations between autoantibodies, cytokines and 30-day survival could be demonstrated, suggesting varied underlying pathological mechanisms. Elevated levels of cytokines and autoantibodies may serve as prognostic indicators for the survival probability of sepsis patients, highlighting the intricate relationship between immune responses and patient outcomes in the context of both sepsis and COVID-19.
Substances chimiques
Autoantibodies
0
Cytokines
0
Antibodies, Viral
0
Types de publication
Journal Article
Langues
eng
Sous-ensembles de citation
IM
Pagination
e29935Subventions
Organisme : Ruhr University Bochum FoRUM Forschungsförderung
ID : P089-23
Organisme : Intramural program of the National Institute of Dental and Craniofacial Research
Organisme : European Regional Development Fund
Organisme : State of North Rhine-Westphalia
Organisme : German Federal Ministry of Education and Research
Organisme : German Research Foundation
ID : STE1954/8-1
Organisme : VIRus-ALlianz NRW (VIRAL)
Organisme : Ministry of Culture and Science of the State of North Rhine-Westfalia
ID : 76.06.04-20/2024-6626
Informations de copyright
© 2024 The Author(s). Journal of Medical Virology published by Wiley Periodicals LLC.
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