The deubiquitinase Ubp3/Usp10 constrains glucose-mediated mitochondrial repression via phosphate budgeting.

Glucose / metabolism Mitochondria / metabolism Saccharomyces cerevisiae / genetics Saccharomyces cerevisiae Proteins / metabolism Phosphates / metabolism Ubiquitin Thiolesterase / metabolism Glycolysis Trehalose / metabolism Endopeptidases
GAPDH S. cerevisiae biochemistry cancer biology chemical biology glycolysis inorganic phosphate metabolic flux mitochondria trehalose

Journal

eLife
ISSN: 2050-084X
Titre abrégé: Elife
Pays: England
ID NLM: 101579614

Informations de publication

Date de publication:
26 Sep 2024
Historique:
medline: 26 9 2024
pubmed: 26 9 2024
entrez: 26 9 2024
Statut: epublish

Résumé

Many cells in high glucose repress mitochondrial respiration, as observed in the Crabtree and Warburg effects. Our understanding of biochemical constraints for mitochondrial activation is limited. Using a

Identifiants

DOI: 10.7554/eLife.90293 PMID: 39324403
pubmed: 39324403
doi: 10.7554/eLife.90293
pii: 90293
doi:
pii:

Substances chimiques

Glucose IY9XDZ35W2
Saccharomyces cerevisiae Proteins 0
Phosphates 0
UBP3 protein, S cerevisiae EC 3.4.99.-
Ubiquitin Thiolesterase EC 3.4.19.12
Trehalose B8WCK70T7I
Endopeptidases EC 3.4.-

Types de publication

Journal Article

Langues

eng

Sous-ensembles de citation

IM

Subventions

Organisme : Wellcome Trust/DBT India Alliance
ID : IA/S/21/2/505922
Organisme : Department of Biotechnology, Ministry of Science and Technology, India
ID : DBT SRNBIOS
Organisme : Department of Science and Technology, Ministry of Science and Technology, India
ID : IF170236
Organisme : Department of Science and Technology, Ministry of Science and Technology, India
ID : CRG/2019/004772

Informations de copyright

© 2023, Vengayil et al.

Déclaration de conflit d'intérêts

VV, SN, SA, SV, SL No competing interests declared

Auteurs

Vineeth Vengayil (V)

Institute for Stem Cell Science and Regenerative Medicine (DBT-inStem), Bangalore, India.
Manipal Academy of Higher Education, Bangalore, India.
ORCID: 0000-0002-1078-5476

Shreyas Niphadkar (S)

Institute for Stem Cell Science and Regenerative Medicine (DBT-inStem), Bangalore, India.
Manipal Academy of Higher Education, Bangalore, India.
ORCID: 0009-0002-4028-395X

Swagata Adhikary (S)

Institute for Stem Cell Science and Regenerative Medicine (DBT-inStem), Bangalore, India.
Manipal Academy of Higher Education, Bangalore, India.
ORCID: 0000-0003-2470-8356

Sriram Varahan (S)

Institute for Stem Cell Science and Regenerative Medicine (DBT-inStem), Bangalore, India.

Sunil Laxman (S)

Institute for Stem Cell Science and Regenerative Medicine (DBT-inStem), Bangalore, India.
ORCID: 0000-0002-0861-5080

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Classifications MeSH

questionsmedicales.fr › Glucides › Sucres › Oses › Hexose › Glucose › The deubiquitinase Ubp3/Usp10 constrains...
questionsmedicales.fr › Cellules › Structures cellulaires › Fractions subcellulaires › Mitochondries › The deubiquitinase Ubp3/Usp10 constrains...
questionsmedicales.fr › Eucaryotes › Champignons › Levures › Saccharomyces › Saccharomyces cerevisiae › The deubiquitinase Ubp3/Usp10 constrains...
questionsmedicales.fr › Acides aminés, peptides et protéines › Protéines › Protéines fongiques › Protéines de Saccharomyces cerevisiae › The deubiquitinase Ubp3/Usp10 constrains...
questionsmedicales.fr › Produits chimiques inorganiques › Composés du phosphore › Acides du phosphore › Acides phosphoriques › Phosphates › The deubiquitinase Ubp3/Usp10 constrains...
questionsmedicales.fr › Acides aminés, peptides et protéines › Protéines › Protéines associées à la maladie de Parkinson › Ubiquitin thiolesterase › The deubiquitinase Ubp3/Usp10 constrains...
questionsmedicales.fr › Métabolisme › Voies et réseaux métaboliques › Glycolyse › The deubiquitinase Ubp3/Usp10 constrains...
questionsmedicales.fr › Glucides › Sucres › Diholoside › Tréhalose › The deubiquitinase Ubp3/Usp10 constrains...
questionsmedicales.fr › Enzymes et coenzymes › Enzymes › Hydrolases › Peptide hydrolases › Endopeptidases › The deubiquitinase Ubp3/Usp10 constrains...