SURF2 is a MDM2 antagonist in triggering the nucleolar stress response.
Journal
Nature communications
ISSN: 2041-1723
Titre abrégé: Nat Commun
Pays: England
ID NLM: 101528555
Informations de publication
Date de publication:
27 Sep 2024
27 Sep 2024
Historique:
received:
21
11
2023
accepted:
16
09
2024
medline:
28
9
2024
pubmed:
28
9
2024
entrez:
27
9
2024
Statut:
epublish
Résumé
Cancer cells rely on high ribosome production to sustain their proliferation rate. Many chemotherapies impede ribosome production which is perceived by cells as "nucleolar stress" (NS), triggering p53-dependent and independent pathways leading to cell cycle arrest and/or apoptosis. The 5S ribonucleoprotein (RNP) particle, a sub-ribosomal particle, is instrumental to NS response. Upon ribosome assembly defects, the 5S RNP accumulates as free form. This free form is able to sequester and inhibit MDM2, thus promoting p53 stabilization. To investigate how cancer cells can resist to NS, here we purify free 5S RNP and uncover an interaction partner, SURF2. Functional characterization of SURF2 shows that its depletion increases cellular sensitivity to NS, while its overexpression promotes their resistance to it. Consistently, SURF2 is overexpressed in many cancers and its expression level is an independent marker of prognosis for adrenocortical cancer. Our data demonstrate that SURF2 buffers free 5S RNP particles, and can modulate their activity, paving the way for the research of new molecules that can finely tune the response to nucleolar stress in the framework of cancer therapies.
Identifiants
pubmed: 39333141
doi: 10.1038/s41467-024-52659-x
pii: 10.1038/s41467-024-52659-x
doi:
Substances chimiques
Proto-Oncogene Proteins c-mdm2
EC 2.3.2.27
MDM2 protein, human
EC 2.3.2.27
Tumor Suppressor Protein p53
0
TP53 protein, human
0
Types de publication
Journal Article
Langues
eng
Sous-ensembles de citation
IM
Pagination
8404Subventions
Organisme : Ligue Contre le Cancer
ID : 62339
Organisme : Ligue Contre le Cancer
ID : Labelisation
Organisme : Institut National Du Cancer (French National Cancer Institute)
ID : PLBIO022-065
Informations de copyright
© 2024. The Author(s).
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