Evolutionary origin and population diversity of a cryptic hybrid pathogen.

Humans Genome, Fungal / genetics Genetic Variation Aspergillus / genetics COVID-19 / virology Phylogeny SARS-CoV-2 / genetics Hybridization, Genetic Phenotype Evolution, Molecular Gene Expression Profiling / methods

Journal

Nature communications
ISSN: 2041-1723
Titre abrégé: Nat Commun
Pays: England
ID NLM: 101528555

Informations de publication

Date de publication:
28 Sep 2024
Historique:
received: 25 06 2024
accepted: 16 09 2024
medline: 28 9 2024
pubmed: 28 9 2024
entrez: 27 9 2024
Statut: epublish

Résumé

Cryptic fungal pathogens pose disease management challenges due to their morphological resemblance to known pathogens. Here, we investigated the genomes and phenotypes of 53 globally distributed isolates of Aspergillus section Nidulantes fungi and found 30 clinical isolates-including four isolated from COVID-19 patients-were A. latus, a cryptic pathogen that originated via allodiploid hybridization. Notably, all A. latus isolates were misidentified. A. latus hybrids likely originated via a single hybridization event during the Miocene and harbor substantial genetic diversity. Transcriptome profiling of a clinical isolate revealed that both parental subgenomes are actively expressed and respond to environmental stimuli. Characterizing infection-relevant traits-such as drug resistance and growth under oxidative stress-revealed distinct phenotypic profiles among A. latus hybrids compared to parental and closely related species. Moreover, we identified four features that could aid A. latus taxonomic identification. Together, these findings deepen our understanding of the origin of cryptic pathogens.

Identifiants

DOI: 10.1038/s41467-024-52639-1 PMID: 39333551
pubmed: 39333551
doi: 10.1038/s41467-024-52639-1
pii: 10.1038/s41467-024-52639-1
doi:

Types de publication

Journal Article

Langues

eng

Sous-ensembles de citation

IM

Pagination

8412

Subventions

Organisme : NIAID NIH HHS
ID : R01 AI153356
Pays : United States
Organisme : National Science Foundation (NSF)
ID : DEB-2110404
Organisme : Burroughs Wellcome Fund (BWF)
ID : N/a
Organisme : Howard Hughes Medical Institute (HHMI)
ID : James H. Gilliam Fellowships for Advanced Study program
Organisme : Howard Hughes Medical Institute (HHMI)
ID : James H. Gilliam Fellowships for Advanced Study program
Organisme : Life Sciences Research Foundation (LSRF)
ID : Howard Hughes Medical Institute Awardee of the Life Sciences Research Foundation

Informations de copyright

© 2024. The Author(s).

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Auteurs

Jacob L Steenwyk (JL)

Howards Hughes Medical Institute and the Department of Molecular and Cell Biology, University of California, Berkeley, Berkeley, USA.
Vanderbilt University, Department of Biological Sciences, VU Station B #35-1634, Nashville, USA.
Evolutionary Studies Initiative, Vanderbilt University, Nashville, USA.

Sonja Knowles (S)

Department of Chemistry & Biochemistry, University of North Carolina at Greensboro, Greensboro, USA.

Rafael W Bastos (RW)

Faculdade de Ciencias Farmacêuticas de Ribeirão Preto, Universidade de São Paulo, São Paulo, Brazil.
Department of Microbiology and Parasitology, Bioscience Center, Federal University of Rio Grande do Norte, Natal-RN, Brazil.

Charu Balamurugan (C)

Vanderbilt University, Department of Biological Sciences, VU Station B #35-1634, Nashville, USA.
Evolutionary Studies Initiative, Vanderbilt University, Nashville, USA.
ORCID: 0009-0006-7746-2248

David Rinker (D)

Vanderbilt University, Department of Biological Sciences, VU Station B #35-1634, Nashville, USA.
Evolutionary Studies Initiative, Vanderbilt University, Nashville, USA.
ORCID: 0000-0001-5894-7633

Matthew E Mead (ME)

Vanderbilt University, Department of Biological Sciences, VU Station B #35-1634, Nashville, USA.
Evolutionary Studies Initiative, Vanderbilt University, Nashville, USA.
Ginkgo Bioworks, 27 Drydock Avenue, 8th Floor, Boston, USA.

Christopher D Roberts (CD)

Department of Chemistry & Biochemistry, University of North Carolina at Greensboro, Greensboro, USA.
ORCID: 0000-0003-0949-1320

Huzefa A Raja (HA)

Department of Chemistry & Biochemistry, University of North Carolina at Greensboro, Greensboro, USA.
ORCID: 0000-0002-0824-9463

Yuanning Li (Y)

Institute of Marine Science and Technology, Shandong University, 72 Binhai Road, Qingdao, China.
ORCID: 0000-0002-2206-5804

Ana Cristina Colabardini (AC)

Faculdade de Ciencias Farmacêuticas de Ribeirão Preto, Universidade de São Paulo, São Paulo, Brazil.

Patrícia Alves de Castro (PA)

Faculdade de Ciencias Farmacêuticas de Ribeirão Preto, Universidade de São Paulo, São Paulo, Brazil.

Thaila Fernanda Dos Reis (TF)

Faculdade de Ciencias Farmacêuticas de Ribeirão Preto, Universidade de São Paulo, São Paulo, Brazil.
ORCID: 0000-0002-7776-977X

Adiyantara Gumilang (A)

Vanderbilt University, Department of Biological Sciences, VU Station B #35-1634, Nashville, USA.
Evolutionary Studies Initiative, Vanderbilt University, Nashville, USA.

María Almagro-Molto (M)

Max von Pettenkofer-Institut für Hygiene und Medizinische Mikrobiologie, Faculty of Medicine, Ludwig Maximilian University, Munich, Germany.

Alexandre Alanio (A)

Institut Pasteur, Paris Cité University, National Reference Center for Invasives Mycoses and Antifungals, Translational Mycology Research Group, Mycology Department, Paris, France.
Laboratoire de parasitologie-mycologie, AP-HP, Hôpital Saint-Louis, Paris, France.

Dea Garcia-Hermoso (D)

Institut Pasteur, Paris Cité University, National Reference Center for Invasives Mycoses and Antifungals, Translational Mycology Research Group, Mycology Department, Paris, France.

Endrews Delbaje (E)

Faculdade de Ciencias Farmacêuticas de Ribeirão Preto, Universidade de São Paulo, São Paulo, Brazil.
ORCID: 0000-0002-0313-9046

Laís Pontes (L)

Faculdade de Ciencias Farmacêuticas de Ribeirão Preto, Universidade de São Paulo, São Paulo, Brazil.

Camila Figueiredo Pinzan (CF)

Faculdade de Ciencias Farmacêuticas de Ribeirão Preto, Universidade de São Paulo, São Paulo, Brazil.

Angélica Zaninelli Schreiber (AZ)

School of Medical Sciences, State University of Campinas, Campinas, Brazil.
ORCID: 0000-0002-5095-5054

David Canóvas (D)

Departamento de Genética, Facultad de Biología, Universidad de Sevilla, Seville, Spain.
Clinical Microbiology Unit. Synlab Laboratory at Viamed Sta. Ángela de la Cruz Hospital, Seville, Spain.
ORCID: 0000-0002-7293-7332

Rafael Sanchez Luperini (R)

Faculdade de Ciencias Farmacêuticas de Ribeirão Preto, Universidade de São Paulo, São Paulo, Brazil.

Katrien Lagrou (K)

Department of Microbiology, Immunology and Transplantation, Katholieke Universiteit Leuven, Leuven, Belgium.
Department of Laboratory Medicine and National Reference Centre for Mycosis, University Hospitals Leuven, Leuven, Belgium.

Egídio Torrado (E)

Life and Health Sciences Research Institute (ICVS), School of Medicine, University of Minho, 4715-495 Braga, Portugal; ICVS/3B's-PT Government Associate Laboratory, Braga, Portugal.
ORCID: 0000-0002-7462-8234

Fernando Rodrigues (F)

Life and Health Sciences Research Institute (ICVS), School of Medicine, University of Minho, 4715-495 Braga, Portugal; ICVS/3B's-PT Government Associate Laboratory, Braga, Portugal.

Nicholas H Oberlies (NH)

Department of Chemistry & Biochemistry, University of North Carolina at Greensboro, Greensboro, USA.
ORCID: 0000-0002-0354-8464

Xiaofan Zhou (X)

Guangdong Laboratory for Lingnan Modern Agriculture, Guangdong Province Key Laboratory of Microbial Signals and Disease Control, Integrative Microbiology Research Centre, South China Agricultural University, Guangzhou, China.
ORCID: 0000-0002-2879-6317

Gustavo H Goldman (GH)

Faculdade de Ciencias Farmacêuticas de Ribeirão Preto, Universidade de São Paulo, São Paulo, Brazil. ggoldman@usp.br.
National Institute of Science and Technology in Human Pathogenic, Fungi, Brazil. ggoldman@usp.br.
ORCID: 0000-0002-2986-350X

Antonis Rokas (A)

Vanderbilt University, Department of Biological Sciences, VU Station B #35-1634, Nashville, USA. antonis.rokas@vanderbilt.edu.
Evolutionary Studies Initiative, Vanderbilt University, Nashville, USA. antonis.rokas@vanderbilt.edu.
ORCID: 0000-0002-7248-6551

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Classifications MeSH

questionsmedicales.fr › Eucaryotes › Animaux › Chordés › Vertébrés › Mammifères › Eutheria › Primates › Haplorhini › Catarrhini › Hominidae › Humains › Evolutionary origin and population diversity...
questionsmedicales.fr › Phénomènes génétiques › Structures génétiques › Génome › Génome microbien › Génome fongique › Evolutionary origin and population diversity...
questionsmedicales.fr › Phénomènes génétiques › Variation génétique › Evolutionary origin and population diversity...
questionsmedicales.fr › Eucaryotes › Champignons › Deuteromycota › Aspergillus › Evolutionary origin and population diversity...
questionsmedicales.fr › Maladies de l'appareil respiratoire › Infections de l'appareil respiratoire › Pneumopathie infectieuse › Pneumopathie virale › COVID-19 › Evolutionary origin and population diversity...
questionsmedicales.fr › Sciences de l'information › Phylogenèse › Evolutionary origin and population diversity...
questionsmedicales.fr › Virus › Virus à ARN › Virus à ARN à brin positif › Nidovirales › Coronaviridae › Coronavirus › Betacoronavirus › Virus du SRAS › SARS-CoV-2 › Evolutionary origin and population diversity...
questionsmedicales.fr › Phénomènes génétiques › Sélection › Hybridation génétique › Evolutionary origin and population diversity...
questionsmedicales.fr › Phénomènes génétiques › Phénotype › Evolutionary origin and population diversity...
questionsmedicales.fr › Phénomènes biologiques › Évolution biologique › Évolution moléculaire › Evolutionary origin and population diversity...
questionsmedicales.fr › Techniques d'investigation › Techniques génétiques › Analyse de profil d'expression de gènes › Evolutionary origin and population diversity...