Freeze-Driven Adsorption of Oligonucleotides with polyA-Anchors on Au@Pt Nanozyme.
freeze–thaw method
gold nanoparticles
lateral flow test
nanozymes
oligonucleotide conjugation
peroxidase-like activity
platinum nanoparticles
spherical nucleic acids
Journal
International journal of molecular sciences
ISSN: 1422-0067
Titre abrégé: Int J Mol Sci
Pays: Switzerland
ID NLM: 101092791
Informations de publication
Date de publication:
20 Sep 2024
20 Sep 2024
Historique:
received:
22
08
2024
revised:
15
09
2024
accepted:
18
09
2024
medline:
28
9
2024
pubmed:
28
9
2024
entrez:
28
9
2024
Statut:
epublish
Résumé
A promising and sought-after class of nanozymes for various applications is Pt-containing nanozymes, primarily Au@Pt, due to their easy preparation and remarkable catalytic properties. This study aimed to explore the freeze-thaw method for functionalizing Pt-containing nanozymes with oligonucleotides featuring a polyadenine anchor. Spherical gold nanoparticles ([Au]NPs) were synthesized and subsequently used as seeds to produce urchin-like Au@Pt nanoparticles ([Au@Pt]NPs) with an average diameter of 29.8 nm. The nanoparticles were conjugated with a series of non-thiolated DNA oligonucleotides, each consisting of three parts: a 5'-polyadenine anchor (A
Identifiants
pubmed: 39337597
pii: ijms251810108
doi: 10.3390/ijms251810108
pii:
doi:
Substances chimiques
Gold
7440-57-5
Oligonucleotides
0
Platinum
49DFR088MY
Poly A
24937-83-5
Types de publication
Journal Article
Langues
eng
Sous-ensembles de citation
IM
Subventions
Organisme : Ministry of Science and Higher Education of the Russian Federation
ID : 075-15-2022-318