Receptor and metabolic insights on the ability of caffeine to prevent alcohol-induced stimulation of mesolimbic dopamine transmission.

Animals Caffeine / pharmacology Dopamine / metabolism Ethanol / pharmacology Male Ventral Tegmental Area / drug effects Nucleus Accumbens / drug effects Dopaminergic Neurons / drug effects Rats Receptor, Adenosine A2A / metabolism Synaptic Transmission / drug effects Adenosine A2 Receptor Antagonists / pharmacology Isoquinolines

Journal

Translational psychiatry
ISSN: 2158-3188
Titre abrégé: Transl Psychiatry
Pays: United States
ID NLM: 101562664

Informations de publication

Date de publication:
28 Sep 2024
Historique:
received: 13 08 2024
accepted: 23 09 2024
revised: 19 09 2024
medline: 29 9 2024
pubmed: 29 9 2024
entrez: 28 9 2024
Statut: epublish

Résumé

The consumption of alcohol and caffeine affects the lives of billions of individuals worldwide. Although recent evidence indicates that caffeine impairs the reinforcing properties of alcohol, a characterization of its effects on alcohol-stimulated mesolimbic dopamine (DA) function was lacking. Acting as the pro-drug of salsolinol, alcohol excites DA neurons in the posterior ventral tegmental area (pVTA) and increases DA release in the nucleus accumbens shell (AcbSh). Here we show that caffeine, via antagonistic activity on A

Identifiants

DOI: 10.1038/s41398-024-03112-6 PMID: 39341817
pubmed: 39341817
doi: 10.1038/s41398-024-03112-6
pii: 10.1038/s41398-024-03112-6
doi:

Substances chimiques

Caffeine 3G6A5W338E
Dopamine VTD58H1Z2X
Ethanol 3K9958V90M
salsolinol 9ILS801M65
Receptor, Adenosine A2A 0
Adenosine A2 Receptor Antagonists 0
Isoquinolines 0

Types de publication

Journal Article

Langues

eng

Sous-ensembles de citation

IM

Pagination

391

Subventions

Organisme : U.S. Department of Health & Human Services | NIH | National Institute on Alcohol Abuse and Alcoholism (NIAAA)
ID : T32AA007456
Organisme : U.S. Department of Health & Human Services | National Institutes of Health (NIH)
ID : AA028982
Organisme : U.S. Department of Health & Human Services | National Institutes of Health (NIH)
ID : AA021667
Organisme : Regione Autonoma della Sardegna (Sardinia Region)
ID : RAS, CRP2_537-CUP F71J090006200002
Organisme : Fondazione Banco di Sardegna (Bank of Sardinia Foundation)
ID : Project ID F74I19000970007 (2018)

Informations de copyright

© 2024. The Author(s).

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Auteurs

Valentina Bassareo (V)

Department of Biomedical Sciences, University of Cagliari, Cittadella Universitaria Monserrato, Monserrato, CA, Italy.

Riccardo Maccioni (R)

Department of Immunology and Microbiology, The Scripps Research Institute, La Jolla, CA, USA. rmaccioni@scripps.edu.
ORCID: 0000-0003-1349-4903

Giuseppe Talani (G)

Institute of Neuroscience - National Research Council (C.N.R.) of Italy, Cagliari, Italy.

Simone Zuffa (S)

Skaggs School of Pharmacy and Pharmaceutical Sciences, University of California San Diego, San Diego, CA, USA.
Collaborative Mass Spectrometry Innovation Center, Skaggs School of Pharmacy and Pharmaceutical Sciences, University of California San Diego, San Diego, CA, USA.
ORCID: 0000-0001-7237-3402

Yasin El Abiead (Y)

Skaggs School of Pharmacy and Pharmaceutical Sciences, University of California San Diego, San Diego, CA, USA.
Collaborative Mass Spectrometry Innovation Center, Skaggs School of Pharmacy and Pharmaceutical Sciences, University of California San Diego, San Diego, CA, USA.

Irene Lorrai (I)

Department of Immunology and Microbiology, The Scripps Research Institute, La Jolla, CA, USA.

Tomoya Kawamura (T)

Department of Immunology and Microbiology, The Scripps Research Institute, La Jolla, CA, USA.

Sofia Pantis (S)

Department of Immunology and Microbiology, The Scripps Research Institute, La Jolla, CA, USA.
Department of Neurology & Neurological Sciences, Stanford University School of Medicine, Stanford, CA, USA.

Roberta Puliga (R)

Department of Life and Environmental Sciences, University of Cagliari, Cittadella Universitaria Monserrato, Monserrato, CA, Italy.

Romina Vargiu (R)

Department of Biomedical Sciences, University of Cagliari, Cittadella Universitaria Monserrato, Monserrato, CA, Italy.

Daniele Lecca (D)

Department of Biomedical Sciences, University of Cagliari, Cittadella Universitaria Monserrato, Monserrato, CA, Italy.

Paolo Enrico (P)

Department of Biomedical Sciences, University of Sassari, Sassari, Italy.

Alessandra Peana (A)

Department of Medical, Surgical and Experimental Sciences, University of Sassari, Sassari, Italy.

Laura Dazzi (L)

Department of Life and Environmental Sciences, University of Cagliari, Cittadella Universitaria Monserrato, Monserrato, CA, Italy.

Pieter C Dorrestein (PC)

Skaggs School of Pharmacy and Pharmaceutical Sciences, University of California San Diego, San Diego, CA, USA.
Collaborative Mass Spectrometry Innovation Center, Skaggs School of Pharmacy and Pharmaceutical Sciences, University of California San Diego, San Diego, CA, USA.

Pietro Paolo Sanna (PP)

Department of Immunology and Microbiology, The Scripps Research Institute, La Jolla, CA, USA.
ORCID: 0000-0002-8307-2151

Enrico Sanna (E)

Institute of Neuroscience - National Research Council (C.N.R.) of Italy, Cagliari, Italy.
Department of Life and Environmental Sciences, University of Cagliari, Cittadella Universitaria Monserrato, Monserrato, CA, Italy.

Elio Acquas (E)

Department of Life and Environmental Sciences, University of Cagliari, Cittadella Universitaria Monserrato, Monserrato, CA, Italy.

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Classifications MeSH

questionsmedicales.fr › Eucaryotes › Animaux › Receptor and metabolic insights on the ability...
questionsmedicales.fr › Composés hétérocycliques › Composés hétérocycliques à cycles fusionnés › Composés hétérobicycliques › Purines › Purinones › Xanthines › Caféine › Receptor and metabolic insights on the ability...
questionsmedicales.fr › Composés chimiques organiques › Hydrocarbures › Hydrocarbures cycliques › Hydrocarbures aromatiques › Dérivés du benzène › Phénols › Catéchols › Catécholamines › Dopamine › Receptor and metabolic insights on the ability...
questionsmedicales.fr › Composés chimiques organiques › Alcools › Éthanol › Receptor and metabolic insights on the ability...
questionsmedicales.fr › Système nerveux › Système nerveux central › Encéphale › Tronc cérébral › Mésencéphale › Pédoncule cérébral › Tegmentum du mésencéphale › Aire tegmentale ventrale › Receptor and metabolic insights on the ability...
questionsmedicales.fr › Système nerveux › Système nerveux central › Encéphale › Prosencéphale › Télencéphale › Cerveau › Noyaux gris centraux › Corps strié › Striatum ventral › Noyau accumbens › Receptor and metabolic insights on the ability...
questionsmedicales.fr › Cellules › Neurones › Neurones dopaminergiques › Receptor and metabolic insights on the ability...
questionsmedicales.fr › Eucaryotes › Animaux › Chordés › Vertébrés › Mammifères › Eutheria › Rodentia › Muridae › Murinae › Rats › Receptor and metabolic insights on the ability...
questionsmedicales.fr › Acides aminés, peptides et protéines › Protéines › Protéines membranaires › Récepteurs de surface cellulaire › Récepteurs aux neuromédiateurs › Récepteurs purinergiques › Récepteurs purinergiques P1 › Récepteurs A2 à l'adénosine › Récepteur A2A à l'adénosine › Receptor and metabolic insights on the ability...
questionsmedicales.fr › Phénomènes physiologiques de l'appareil locomoteur et du système nerveux › Phénomènes physiologiques du système nerveux › Transmission synaptique › Receptor and metabolic insights on the ability...
questionsmedicales.fr › Actions chimiques et utilisations › Actions pharmacologiques › Effets physiologiques des médicaments › Agents neuromédiateurs › Agents purinergiques › Antagonistes purinergiques › Antagonistes des récepteurs purinergiques P1 › Antagonistes des récepteurs A2 à l'adénosine › Receptor and metabolic insights on the ability...
questionsmedicales.fr › Composés hétérocycliques › Composés hétérocycliques à cycles fusionnés › Composés hétérobicycliques › Isoquinoléines › Receptor and metabolic insights on the ability...