Antidiarrheal properties of Ligusticum chuanxiong Hort's ethanol extract in mice and its impact on the contraction of rabbits' isolated jejunal smooth muscles.
Animals
Rabbits
Antidiarrheals
/ pharmacology
Jejunum
/ drug effects
Muscle, Smooth
/ drug effects
Muscle Contraction
/ drug effects
Mice
Male
Ligusticum
/ chemistry
Ethanol
/ chemistry
Diarrhea
/ drug therapy
Plant Extracts
/ pharmacology
Drugs, Chinese Herbal
/ pharmacology
Dose-Response Relationship, Drug
Castor Oil
Journal
Pakistan journal of pharmaceutical sciences
ISSN: 1011-601X
Titre abrégé: Pak J Pharm Sci
Pays: Pakistan
ID NLM: 9426356
Informations de publication
Date de publication:
Jul 2024
Jul 2024
Historique:
medline:
30
9
2024
pubmed:
30
9
2024
entrez:
30
9
2024
Statut:
ppublish
Résumé
Ligusticum chuanxiong Hort (CR) is the dried rhizome of Ligusticum belongs to the Umbelliferae family. The present study aimed to assess the antidiarrheal effects of ethanol extracts of CR (CR ext.). The mice were administered castor oil to induce diarrhea and the antidiarrheal effects of CR ext (250, 500 and 1000mg/kg) were assessed in vivo. The potential effect of CR ext (0.01-10 mg/mL) was examined on isolated rabbit jejunum smooth muscle in vitro. CR ext exhibited antidiarrheal effects at a dose ranging from 500 to 1000 mg/kg (P <0.01). CR ext (0.01-10 mg/mL) relaxed the smooth muscles in a dose-dependent manner and its median effective concentration (EC
Substances chimiques
Antidiarrheals
0
Ethanol
3K9958V90M
Plant Extracts
0
Drugs, Chinese Herbal
0
Castor Oil
8001-79-4
Types de publication
Journal Article
Langues
eng
Sous-ensembles de citation
IM