Genomic analysis of an acute gastroenteritis outbreak caused by rotavirus C in Hebei, China.

Humans Gastroenteritis / virology Disease Outbreaks Rotavirus Infections / virology China / epidemiology Rotavirus / genetics Phylogeny Genome, Viral Genotype Male Child, Preschool RNA, Viral / genetics Whole Genome Sequencing Female Sequence Analysis, DNA Infant Genetic Variation Reassortant Viruses / genetics Cluster Analysis
Genetic recombination Human rotavirus C Phylogenetic analysis

Journal

Virology journal
ISSN: 1743-422X
Titre abrégé: Virol J
Pays: England
ID NLM: 101231645

Informations de publication

Date de publication:
02 Oct 2024
Historique:
received: 10 06 2024
accepted: 29 08 2024
medline: 3 10 2024
pubmed: 3 10 2024
entrez: 2 10 2024
Statut: epublish

Résumé

Rotavirus group C is an important cause of sporadic cases and outbreaks of gastroenteritis worldwide. Whole-Genome sequences of human rotavirus C (RVC) in public databases are limited. We performed genome sequencing to analyze a RVC outbreak of acute gastroenteritis in China. Samples from 22 patients were screened for pathogens using RT-PCR, and six samples were positive for rotavirus. Whole-Genome sequencing analysis showed that the outbreak strain SJZ217 belongs to the G4-P[2]-I2-R2-C2-M3-A2-N2-T2-E2-H2 genotype and shares almost identical genomic sequences with Chungnam isolated in Korea. Phylogenetic analysis revealed strain SJZ217 also fell into a cluster with rotavirus C strains from Japan and Europe. Reassortment in the VP4 fragment was observed. These results helped to understand the genetic diversity and possible spread of RVC strains.

Identifiants

DOI: 10.1186/s12985-024-02486-9 PMID: 39358760
pubmed: 39358760
doi: 10.1186/s12985-024-02486-9
pii: 10.1186/s12985-024-02486-9
doi:

Substances chimiques

RNA, Viral 0

Types de publication

Journal Article

Langues

eng

Sous-ensembles de citation

IM

Pagination

242

Subventions

Organisme : National Key Research and Development Program of China
ID : 2023YFC2604400
Organisme : National Science and Technology Major Project
ID : 2018ZX10305410

Informations de copyright

© 2024. The Author(s).

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Auteurs

Kaiying Wang (K)

Chinese PLA Center for Disease Control and Prevention, 20 Dongda Street, Fengtai District, Beijing, 100071, China.

Yun Wang (Y)

Tianjin Binhai New Area Center for Disease Control and Prevention, Tianjin, 300450, China.

Lang Yang (L)

Chinese PLA Center for Disease Control and Prevention, 20 Dongda Street, Fengtai District, Beijing, 100071, China.

Jinhui Li (J)

Chinese PLA Center for Disease Control and Prevention, 20 Dongda Street, Fengtai District, Beijing, 100071, China.

Peihan Li (P)

Chinese PLA Center for Disease Control and Prevention, 20 Dongda Street, Fengtai District, Beijing, 100071, China.

Chaojie Yang (C)

Chinese PLA Center for Disease Control and Prevention, 20 Dongda Street, Fengtai District, Beijing, 100071, China.

Leili Jia (L)

Chinese PLA Center for Disease Control and Prevention, 20 Dongda Street, Fengtai District, Beijing, 100071, China.

Shaofu Qiu (S)

Chinese PLA Center for Disease Control and Prevention, 20 Dongda Street, Fengtai District, Beijing, 100071, China. qiushf0613@hotmail.com.

Hongbin Song (H)

Chinese PLA Center for Disease Control and Prevention, 20 Dongda Street, Fengtai District, Beijing, 100071, China. hongbinsong@263.net.

Peng Li (P)

Chinese PLA Center for Disease Control and Prevention, 20 Dongda Street, Fengtai District, Beijing, 100071, China. jiekenlee@126.com.

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Classifications MeSH

questionsmedicales.fr › Eucaryotes › Animaux › Chordés › Vertébrés › Mammifères › Eutheria › Primates › Haplorhini › Catarrhini › Hominidae › Humains › Genomic analysis of an acute gastroenteritis...
questionsmedicales.fr › Maladies de l'appareil digestif › Maladies gastro-intestinales › Gastroentérite › Genomic analysis of an acute gastroenteritis...
questionsmedicales.fr › Environnement et santé publique › Santé publique › Épidémies de maladies › Genomic analysis of an acute gastroenteritis...
questionsmedicales.fr › Infection › Maladies virales › Infections à virus à ARN › Infections à Reoviridae › Infections à rotavirus › Genomic analysis of an acute gastroenteritis...
questionsmedicales.fr › Régions géographiques › Asie › Extrême-Orient › Chine › Genomic analysis of an acute gastroenteritis...
questionsmedicales.fr › Virus › Virus à ARN › Virus à ARN double brin › Reoviridae › Rotavirus › Genomic analysis of an acute gastroenteritis...
questionsmedicales.fr › Sciences de l'information › Phylogenèse › Genomic analysis of an acute gastroenteritis...
questionsmedicales.fr › Phénomènes génétiques › Structures génétiques › Génome › Génome microbien › Génome viral › Genomic analysis of an acute gastroenteritis...
questionsmedicales.fr › Phénomènes génétiques › Génotype › Genomic analysis of an acute gastroenteritis...
questionsmedicales.fr › Personnes › Tranches d'âge › Enfant › Enfant d'âge préscolaire › Genomic analysis of an acute gastroenteritis...
questionsmedicales.fr › Acides nucléiques, nucléotides et nucléosides › Acides nucléiques › ARN › ARN viral › Genomic analysis of an acute gastroenteritis...
questionsmedicales.fr › Techniques d'investigation › Techniques génétiques › Analyse de séquence › Analyse de séquence d'ADN › Séquençage du génome entier › Genomic analysis of an acute gastroenteritis...
questionsmedicales.fr › Techniques d'investigation › Techniques génétiques › Analyse de séquence › Analyse de séquence d'ADN › Genomic analysis of an acute gastroenteritis...
questionsmedicales.fr › Personnes › Tranches d'âge › Nourrisson › Genomic analysis of an acute gastroenteritis...
questionsmedicales.fr › Phénomènes génétiques › Variation génétique › Genomic analysis of an acute gastroenteritis...
questionsmedicales.fr › Virus › Virus recombinants › Genomic analysis of an acute gastroenteritis...
questionsmedicales.fr › Environnement et santé publique › Santé publique › Méthodes épidémiologiques › Statistiques comme sujet › Analyse de regroupements › Genomic analysis of an acute gastroenteritis...