Engineering substrate channeling in a bifunctional terpene synthase.

Alkyl and Aryl Transferases / metabolism Substrate Specificity Polyisoprenyl Phosphates / metabolism Protein Engineering Catalytic Domain Diterpenes / metabolism
cryo-electron microscopy enzyme catalysis protein engineering

Journal

Proceedings of the National Academy of Sciences of the United States of America
ISSN: 1091-6490
Titre abrégé: Proc Natl Acad Sci U S A
Pays: United States
ID NLM: 7505876

Informations de publication

Date de publication:
08 Oct 2024
Historique:
medline: 4 10 2024
pubmed: 4 10 2024
entrez: 4 10 2024
Statut: ppublish

Résumé

Fusicoccadiene synthase from

Identifiants

DOI: 10.1073/pnas.2408064121 PMID: 39365814
pubmed: 39365814
doi: 10.1073/pnas.2408064121
doi:

Substances chimiques

Alkyl and Aryl Transferases EC 2.5.-
terpene synthase EC 2.5.1.-
Polyisoprenyl Phosphates 0
geranylgeranyl pyrophosphate N21T0D88LX
Diterpenes 0

Types de publication

Journal Article

Langues

eng

Sous-ensembles de citation

IM

Pagination

e2408064121

Subventions

Organisme : HHS | NIH | National Institute of General Medical Sciences (NIGMS)
ID : R01 GM56838
Organisme : NIGMS NIH HHS
ID : R35 GM118090
Pays : United States
Organisme : NIGMS NIH HHS
ID : T32 GM133398
Pays : United States

Déclaration de conflit d'intérêts

Competing interests statement:The authors declare no competing interest.

Auteurs

Eliott S Wenger (ES)

Roy and Diana Vagelos Laboratories, Department of Chemistry, University of Pennsylvania, Philadelphia, PA 19104-6323.
ORCID: 0000-0001-6391-8036

Kollin Schultz (K)

Abramson Family Cancer Research Institute, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA 19104.
Graduate Group in Biochemistry and Molecular Biophysics, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA 19104.
ORCID: 0000-0002-4456-8349

Ronen Marmorstein (R)

Abramson Family Cancer Research Institute, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA 19104.
Department of Biochemistry and Biophysics, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA 19104.
ORCID: 0000-0003-4373-4752

David W Christianson (DW)

Roy and Diana Vagelos Laboratories, Department of Chemistry, University of Pennsylvania, Philadelphia, PA 19104-6323.
ORCID: 0000-0002-0194-5212

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Classifications MeSH

questionsmedicales.fr › Enzymes et coenzymes › Enzymes › Transferases › Alkyl et aryl transferases › Engineering substrate channeling in a...
questionsmedicales.fr › Phénomènes chimiques › Phénomènes biochimiques › Spécificité du substrat › Engineering substrate channeling in a...
questionsmedicales.fr › Composés chimiques organiques › Composés organiques du phosphore › Organophosphates › Polyisoprényl-phosphates › Engineering substrate channeling in a...
questionsmedicales.fr › Techniques d'investigation › Techniques génétiques › Génie génétique › Ingénierie des protéines › Engineering substrate channeling in a...
questionsmedicales.fr › Phénomènes chimiques › Phénomènes biochimiques › Conformation moléculaire › Conformation des protéines › Éléments structuraux des protéines › Domaine catalytique › Engineering substrate channeling in a...
questionsmedicales.fr › Composés chimiques organiques › Hydrocarbures › Terpènes › Diterpènes › Engineering substrate channeling in a...