Drug-resistant Pantoea agglomerans Causing Bacteremia at a Tertiary Care Hospital in Kolkata, India: First Report of Carbapenem Resistance Mediated by OXA-181.
Humans
India
Tertiary Care Centers
/ statistics & numerical data
Bacteremia
/ microbiology
beta-Lactamases
/ genetics
Pantoea
/ genetics
Plasmids
/ genetics
Anti-Bacterial Agents
/ pharmacology
Carbapenems
/ pharmacology
Microbial Sensitivity Tests
Enterobacteriaceae Infections
/ microbiology
Bacterial Proteins
/ genetics
Drug Resistance, Multiple, Bacterial
/ genetics
Male
Journal
Current microbiology
ISSN: 1432-0991
Titre abrégé: Curr Microbiol
Pays: United States
ID NLM: 7808448
Informations de publication
Date de publication:
05 Oct 2024
05 Oct 2024
Historique:
received:
27
05
2024
accepted:
06
09
2024
medline:
6
10
2024
pubmed:
6
10
2024
entrez:
5
10
2024
Statut:
epublish
Résumé
The spread of antibiotic resistance (ABR) in uncommon human pathogens endangers global public health, escalating morbidity, death, and healthcare expenditures. Pantoea agglomerans, a member of the Erwiniaceae family that rarely infects humans, is emerging as a drug-resistant nosocomial pathogen. Seven P. agglomerans isolates were recovered from bacteremia patients at a tertiary care hospital in Kolkata, West Bengal, between March 2022 and October 2022. The isolates were evaluated for phenotypic resistance, β-lactamase and plasmid-mediated quinolone resistance (PMQR) genes, plasmid profiling, and clonality assessment. All isolates were resistant to fluoroquinolones and third-generation cephalosporins, with four resistant to carbapenems. The following β-lactamases and PMQR genes were identified: bla
Identifiants
pubmed: 39367887
doi: 10.1007/s00284-024-03888-2
pii: 10.1007/s00284-024-03888-2
doi:
Substances chimiques
beta-Lactamases
EC 3.5.2.6
Anti-Bacterial Agents
0
Carbapenems
0
Bacterial Proteins
0
Types de publication
Journal Article
Langues
eng
Sous-ensembles de citation
IM
Pagination
389Subventions
Organisme : Indian Council of Medical Research
ID : AMR/Adhoc/241/2020-ECD-II
Informations de copyright
© 2024. The Author(s), under exclusive licence to Springer Science+Business Media, LLC, part of Springer Nature.
Références
Shrestha B, Nabin KC, Bastola C, Jahir T, Risal R, Thapa S, Enriquez D, Schmidt F, Thapa S (2021) Pantoea agglomerans: An elusive contributor to chronic obstructive pulmonary disease exacerbation. Cureus 13:e18562. https://doi.org/10.7759/cureus.18562
doi: 10.7759/cureus.18562
pubmed: 34760410
pmcid: 8571802
Gavini F, Mergaert J, Beji AM, Mielcarek C, Izard D, Kersters K, De Ley J (1989). Transfer of Enterobacter agglomerans (Beijerinck 1888) Ewing and Fife 1972 to Pantoea gen. nov. as Pantoea agglomerans comb, nov. and Description of Pantoea dispersa sp. nov.Int J Syst Evol. https://doi.org/10.1099/00207713-39-3-337
Dutkiewicz J, Mackiewicz B, Lemieszek MK, Golec M, Milanowski J (2015) Pantoeaagglomerans: a mysterious bacterium of evil and good. Part I. deleterious effects: dust-borne endotoxins and allergens-focus on cotton dust. Ann Agric Environ Med. https://doi.org/10.5604/12321966.1185757
doi: 10.5604/12321966.1185757
pubmed: 26706961
Cunningham DJ, Leber A (2018) Enterobacter, Cronobacter, and Pantoea species. Int J Infect Dis, In Principles and practice of pediatric. https://doi.org/10.1016/B978-0-323-40181-4.00140-7
doi: 10.1016/B978-0-323-40181-4.00140-7
Walterson AM, Stavrinides J (2015) Pantoea: insights into a highly versatile and diverse genus within the Enterobacteriaceae. FEMS Microbiol Rev 39:968–984. https://doi.org/10.1093/femsre/fuv027
doi: 10.1093/femsre/fuv027
pubmed: 26109597
Büyükcam A, Tuncer Ö, Gür D, Sancak B, Ceyhan M, Cengiz AB, Kara A (2018) Clinical and microbiological characteristics of Pantoeaagglomerans infection in children. J Infect Public Health 11:304–309. https://doi.org/10.1016/j.jiph.2017.07.020
doi: 10.1016/j.jiph.2017.07.020
pubmed: 28780309
Cruz AT, Cazacu AC, Allen CH (2007) Pantoeaagglomerans, a plant pathogen causing human disease. J Clin Microbiol 45:1989–1992. https://doi.org/10.1128/JCM.00632-07
doi: 10.1128/JCM.00632-07
pubmed: 17442803
pmcid: 1933083
Haralampidou H, Ladomenou F, Gkountoula T, Mertzidis P, Giannousi E (2022) Pantoeaagglomerans Bacteremia: a rare case of Bacteremia in an immunocompetent four-year-old child. Cureus. https://doi.org/10.7759/cureus.26080
doi: 10.7759/cureus.26080
pubmed: 35875297
pmcid: 9295193
Flores Popoca EO, Miranda García M, Romero Figueroa S, Mendoza Medellín A, Sandoval Trujillo H, Silva Rojas HV, RamírezDurán N (2012) Pantoeaagglomerans in immunodeficient patients with different respiratory symptoms. Sci World J. https://doi.org/10.1100/2012/156827
doi: 10.1100/2012/156827
Raphael E, Riley LW (2017) Infections caused by antimicrobial drug-resistant saprophytic Gram-negative bacteria in the environment. Front Med 4:183. https://doi.org/10.3389/fmed.2017.00183
doi: 10.3389/fmed.2017.00183
Guevarra RB, Magez S, Peeters E, Chung MS, Kim KH, Radwanska M (2021) Comprehensive genomic analysis reveals virulence factors and antibiotic resistance genes in Pantoea agglomerans KM1, a potential opportunistic pathogen. PLoS ONE 16:e0239792. https://doi.org/10.1371/journal.pone.0239792
doi: 10.1371/journal.pone.0239792
pubmed: 33406073
pmcid: 7787473
De Champs C, Le Seaux S, Dubost JJ, Boisgard S, Sauvezie B, Sirot J (2000) Isolation of Pantoea agglomerans in two cases of septic monoarthritis after plant thorn and wood sliver injuries. J Clin Microbiol 38:460–461. https://doi.org/10.1128/JCM.38.1.460-461.2000
doi: 10.1128/JCM.38.1.460-461.2000
pubmed: 10618144
pmcid: 88752
Kratz A, Greenberg D, Barki Y, Cohen E, Lifshitz M (2003) Pantoea agglomerans as a cause of septic arthritis after palm tree thorn injury; case report and literature review. Arch Dis Child 88:542–544. https://doi.org/10.1136/adc.88.6.542
doi: 10.1136/adc.88.6.542
pubmed: 12765929
pmcid: 1763127
Patel S, Prabhakar H, Kapoor I (2023) Rate of Multidrug-resistance to antimicrobial drugs in patients in pediatric neuro-intensive care. Indian J Crit Care Med 27:67. https://doi.org/10.5005/jp-journals-10071-24377
doi: 10.5005/jp-journals-10071-24377
pubmed: 36756473
pmcid: 9886037
Sengupta M, Banerjee S, Das NK, Guchhait P, Misra S (2016) Early onset neonatal septicaemia caused by Pantoeaagglomerans. J Clin Diagn Res. 10(5):DD01-2. https://doi.org/10.7860/JCDR/2016/19613.7807
doi: 10.7860/JCDR/2016/19613.7807
pubmed: 27437219
pmcid: 4948395
Khajuria A, Praharaj AK, Kumar M, Grover N (2014) Emergence of NDM-1 in a clinical isolate of Pantoeaagglomerans from India. J Glob Antimicrob Resist 2:340–341. https://doi.org/10.1016/j.jgar.2014.05.009
doi: 10.1016/j.jgar.2014.05.009
pubmed: 27873700
Tiwari S, Beriha SS (2015) Pantoea species causing early onset neonatal sepsis a case report. J Med Case Rep. https://doi.org/10.1186/s13256-015-0670-0
doi: 10.1186/s13256-015-0670-0
pubmed: 26341678
pmcid: 4560869
Sudhalkar A, Majji AB, Chhablani J, Manderwad G (2014) Pantoea agglomerans endophthalmitis: clinical features and outcomes. Retina 34(8):1702–1706. https://doi.org/10.1097/IAE.0000000000000127
doi: 10.1097/IAE.0000000000000127
pubmed: 24671031
Kenchappa P, Rao KR, Ahmed N, Joshi S, Ghousunnissa S, Vijayalakshmi V, Murthy KJ (2006) Fluorescent amplified fragment length polymorphism (FAFLP) based molecular epidemiology of hospital infections in a tertiary care setting in Hyderabad. India. Infect Genet Evol. 6(3):220–227. https://doi.org/10.1016/j.meegid.2005.05.003
doi: 10.1016/j.meegid.2005.05.003
pubmed: 16054876
Jain S, Bohra I, Mahajan R, Jain S, Chugh TD (2012) Pantoea agglomerans infection behaving like a tumor after plant thorn injury: an unusual presentation. Indian J Pathol Microbiol 55(3):386–388. https://doi.org/10.4103/0377-4929.101754
doi: 10.4103/0377-4929.101754
pubmed: 23032841
Siwakoti S, Sah R, Rajbhandari RS, Khanal B (2018) Pantoea agglomerans infections in children report of two cases. Case Rep Pediatr. https://doi.org/10.1155/2018/4158734
doi: 10.1155/2018/4158734
pubmed: 29527373
pmcid: 5828082
Sharma M et al (2012) Multidrug Resistant Pantoea agglomerans in a Patient with Septic Arthritis-a Rare Report from India. Int J Microbiol Res. https://doi.org/10.9735/0975-5276.4.6.263-265
doi: 10.9735/0975-5276.4.6.263-265
Priscilla J, Jagadeeswari S (2019) Pantoea infection-A rare case report from South India. Drug Invention Today 11(11):2783–2785
Naha K, Ramamoorthi PM (2012) Spontaneous septicaemia with multi-organ dysfunction–a new face for Pantoe agglomerans? Asian Pac J Trop Med 5(1):83–84. https://doi.org/10.1016/S1995-7645(11)60252-6
doi: 10.1016/S1995-7645(11)60252-6
pubmed: 22182651
Samreen AI, Malak HA, Abulreesh HH (2021) Environmental antimicrobial resistance and its drivers: a potential threat to public health. J Glob Antimicrob Resist. 27:101–111. https://doi.org/10.1016/j.jgar.2021.08.001
doi: 10.1016/j.jgar.2021.08.001
pubmed: 34454098
Aibinu I, Pfeifer Y, Peters F, Ogunsola F, Adenipekun E, Odugbemi T, König W (2012) Emergence of bla
doi: 10.1099/jmm.0.035238-0
pubmed: 21921107
Aryal PU, Thamjarungwong B, Singkhamanan K, Thongsuksai P, Ingviya N, Laohaprertthisan V, Darayon R, Yingkajorn M (2020) Emergence of carbapenem-resistant Enterobacteriaceae in a tertiary care hospital in Southern Thailand. Walailak J Sci Tech 17(10):1139–1148. https://doi.org/10.48048/wjst.2020.10729
doi: 10.48048/wjst.2020.10729
Saticioglu IB, Duman M, Altun S (2018) Antimicrobial resistance and molecular characterization of Pantoeaagglomerans isolated from rainbow trout (Oncorhynchus mykiss) fry. Microbpathog. 119:131–136. https://doi.org/10.1016/j.micpath.2018.04.022
doi: 10.1016/j.micpath.2018.04.022
The Clinical and Laboratory Standards Institute. Performance standards for antimicrobial susceptibility testing. 31st ed., CLSI supplement M100. 2021, Wayne, PA. https://clsi.org/standards/products/microbiology/ documents/m100/
Srinivasan R, Karaoz U, Volegova M, MacKichan J, Kato-Maeda M, Miller S, Nadarajan R, Brodie EL, Lynch SV (2015) Use of 16S rRNA gene for identification of a broad range of clinically relevant bacterial pathogens. PLoS ONE 10(2):e0117617. https://doi.org/10.1371/journal.pone.0117617
doi: 10.1371/journal.pone.0117617
pubmed: 25658760
pmcid: 4319838
Morales SE, Holben WE (2009) Empirical testing of 16S rRNA gene PCR primer pairs reveals variance in target specificity and efficacy not suggested by in silico analysis. Appl Environ Microbiol 75(9):2677–2683. https://doi.org/10.1128/AEM.02166-08
doi: 10.1128/AEM.02166-08
pubmed: 19251890
pmcid: 2681686
Das S, Mallick A, Barik M, Sarkar S, Saha P (2023) The emergence of clonally diverse carbapenem-resistant Enterobacter cloacae complex in West Bengal, India: a dockyard of β-lactamases periling nosocomial infections. Int Microbiol. https://doi.org/10.1007/s10123-023-00451-0
doi: 10.1007/s10123-023-00451-0
pubmed: 37985632
Mallick A, Barik M, Sarkar S, Das S (2024) β-lactamase and plasmid-mediated quinolone resistance determinants among Proteus spp. isolates at a tertiary-care hospital in Kolkata, India. Anti-Infect Agents 22(3):79–83. https://doi.org/10.2174/0122113525279277231223035547
doi: 10.2174/0122113525279277231223035547
Casale R, Boattini M, Bianco G, Comini S, Corcione S, Garazzino S, Silvestro E, De Rosa FG, Cavallo R, Costa C (2023) Bloodstream infections by Pantoea species: clinical and microbiological findings from a retrospective study, Italy, 2018–2023. Antibiotics (Basel) 12(12):1723. https://doi.org/10.3390/antibiotics12121723
doi: 10.3390/antibiotics12121723
pubmed: 38136757
Kaur IP, Inkollu S, Prakash A, Gandhi H, Mughal MS, Du D (2020) Pantoea agglomerans bacteremia: is it dangerous? Case Rep Infect Dis 2020:7890305. https://doi.org/10.1155/2020/7890305
doi: 10.1155/2020/7890305
pubmed: 32313708
pmcid: 7160720
Penner M, Romans B, Tah L, Argubright B, Strohmeyer M (2022) Successful treatment of Pantoea agglomerans bacteremia using oral antibiotics. Case Rep Int J Infect Dis 2022:6136265. https://doi.org/10.1155/2022/6136265
doi: 10.1155/2022/6136265
Mardaneh J, Dallal MM (2013) Isolation, identification and antimicrobial susceptibility of Pantoea (Enterobacter) agglomerans isolated from consumed powdered infant formula milk (PIF) in NICU ward: first report from Iran. Iran J Microbiol 5(3):263–267
pubmed: 24475334
pmcid: 3895565
Markovska RD, Stoeva TJ, Bojkova KD, Mitov IG (2014) Epidemiology and molecular characterization of extended-spectrum beta-lactamase-producing Enterobacter spp., Pantoeaagglomerans, and Serratia marcescens isolates from a Bulgarian hospital. Microb Drug Resist 20(2):131–137. https://doi.org/10.1089/mdr.2013.0102
doi: 10.1089/mdr.2013.0102
pubmed: 24171449
Bachmeyer C, Entressengle H, Gibeault M, Nédellec G, M’Bappé P, Delisle F, Jacquot F, Arlet G, Grateau G, Lionnet F (2007) Bilateral tibial chronic osteomyelitis due to Pantoea agglomerans in a patient with sickle cell disease. Rheumatology (Oxford) 46(8):1247. https://doi.org/10.1093/rheumatology/kem127
doi: 10.1093/rheumatology/kem127
pubmed: 17650525
Haji SH, Aka STH, Ali FA (2021) Prevalence and characterisation of carbapenemase encoding genes in multidrug-resistant Gram-negative bacilli. PLoS ONE 16(11):e0259005. https://doi.org/10.1371/journal.pone.0259005
doi: 10.1371/journal.pone.0259005
pubmed: 34723978
pmcid: 8559951
Hortaçİştar E, Alışkan HE, Göçmen JS (2021) Diverse efficacy of CarbaNP test among OXA-48 carbapenemase producing Enterobacterales in an endemic region. Acta Microbiol Immunol Hung 68(1):34–39. https://doi.org/10.1556/030.2021.01220
doi: 10.1556/030.2021.01220
Kopotsa K, Osei Sekyere J, Mbelle NM (2019) Plasmid evolution in carbapenemase-producing Enterobacteriaceae: a review. Ann N Y Acad Sci 1457(1):61–91. https://doi.org/10.1111/nyas.14223
doi: 10.1111/nyas.14223
pubmed: 31469443
Ramirez MS, Iriarte A, Reyes-Lamothe R, Sherratt DJ, Tolmasky ME (2019) Small Klebsiella pneumoniae plasmids: neglected contributors to antibiotic resistance. Front Microbiol 10:2182. https://doi.org/10.3389/fmicb.2019.02182
doi: 10.3389/fmicb.2019.02182
pubmed: 31616398
pmcid: 6764390