The origin of methyl group in methanogen-mediated mercury methylation: From the Wolfe cycle.

Methylation Methylmercury Compounds / metabolism Methane / metabolism Mercury / metabolism Methanospirillum / metabolism Proteomics / methods
Wolfe cycle mechanism mercury methylation methanogens methylmercury

Journal

Proceedings of the National Academy of Sciences of the United States of America
ISSN: 1091-6490
Titre abrégé: Proc Natl Acad Sci U S A
Pays: United States
ID NLM: 7505876

Informations de publication

Date de publication:
15 Oct 2024
Historique:
medline: 9 10 2024
pubmed: 9 10 2024
entrez: 9 10 2024
Statut: ppublish

Résumé

Methylmercury (MeHg) is a bioaccumulating neurotoxin mainly produced by anaerobic microorganisms, with methanogen being one of the important methylators. A critical aspect for understanding the mechanism for microbial mercury (Hg) methylation is the origin of the methyl group. However, the origin of methyl group in methanogen-mediated Hg methylation remains unclear. This study aims to identify the source of methyl group for MeHg synthesis in methanogens. Our study revealed that Hg methylation in

Identifiants

DOI: 10.1073/pnas.2416761121 PMID: 39382993
pubmed: 39382993
doi: 10.1073/pnas.2416761121
doi:

Substances chimiques

Methylmercury Compounds 0
Methane OP0UW79H66
Mercury FXS1BY2PGL

Types de publication

Journal Article

Langues

eng

Sous-ensembles de citation

IM

Pagination

e2416761121

Subventions

Organisme : MOST | National Natural Science Foundation of China (NSFC)
ID : 42025704
Organisme : MOST | NSFC | National Natural Science Foundation of China-Yunnan Joint Fund (NSFC-Yunnan Joint Fund)
ID : 22193052
Organisme : MOST | National Key Research and Development Program of China (NKPs)
ID : 2020YFA0907500
Organisme : MOST | National Key Research and Development Program of China (NKPs)
ID : 2020YFA0907400
Organisme : CAS | Research Center for Eco-Environmental Sciences, Chinese Academy of Sciences (RCEES, CAS)
ID : RCEES-TDZ-2021-22

Déclaration de conflit d'intérêts

Competing interests statement:The authors declare no competing interest.

Auteurs

Jun Gao (J)

State Key Laboratory of Environmental Chemistry and Ecotoxicology, Research Center for Eco-Environmental Sciences, Chinese Academy of Sciences, Beijing 100085, China.
College of Resources and Environment, University of Chinese Academy of Sciences, Beijing 100049, China.
ORCID: 0000-0002-1014-3318

Jingyi Yang (J)

State Key Laboratory of Environmental Chemistry and Ecotoxicology, Research Center for Eco-Environmental Sciences, Chinese Academy of Sciences, Beijing 100085, China.

Hongzhe Dong (H)

State Key Laboratory of Environmental Chemistry and Ecotoxicology, Research Center for Eco-Environmental Sciences, Chinese Academy of Sciences, Beijing 100085, China.

Shaoyang Tao (S)

State Key Laboratory of Environmental Chemistry and Ecotoxicology, Research Center for Eco-Environmental Sciences, Chinese Academy of Sciences, Beijing 100085, China.

Jianbo Shi (J)

State Key Laboratory of Environmental Chemistry and Ecotoxicology, Research Center for Eco-Environmental Sciences, Chinese Academy of Sciences, Beijing 100085, China.
School of Environment, Hangzhou Institute for Advanced Study, University of Chinese Academy of Sciences, Hangzhou 310000, China.

Bin He (B)

State Key Laboratory of Environmental Chemistry and Ecotoxicology, Research Center for Eco-Environmental Sciences, Chinese Academy of Sciences, Beijing 100085, China.
School of Environment, Hangzhou Institute for Advanced Study, University of Chinese Academy of Sciences, Hangzhou 310000, China.

Xiqing Bian (X)

School of Pharmarcy, Macau University of Science and Technology, Macau 999078, China.

Jian-Lin Wu (JL)

School of Pharmarcy, Macau University of Science and Technology, Macau 999078, China.

Yongguang Yin (Y)

State Key Laboratory of Environmental Chemistry and Ecotoxicology, Research Center for Eco-Environmental Sciences, Chinese Academy of Sciences, Beijing 100085, China.
School of Environment and Health, Jianghan University, Wuhan 430056, China.
ORCID: 0000-0002-7287-8598

Ligang Hu (L)

State Key Laboratory of Environmental Chemistry and Ecotoxicology, Research Center for Eco-Environmental Sciences, Chinese Academy of Sciences, Beijing 100085, China.
College of Resources and Environment, University of Chinese Academy of Sciences, Beijing 100049, China.
School of Environment, Hangzhou Institute for Advanced Study, University of Chinese Academy of Sciences, Hangzhou 310000, China.
School of Environment and Health, Jianghan University, Wuhan 430056, China.
ORCID: 0000-0002-6213-4720

Guibin Jiang (G)

State Key Laboratory of Environmental Chemistry and Ecotoxicology, Research Center for Eco-Environmental Sciences, Chinese Academy of Sciences, Beijing 100085, China.
ORCID: 0000-0002-6335-3917

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Classifications MeSH

questionsmedicales.fr › Métabolisme › Alkylation › Méthylation › The origin of methyl group in...
questionsmedicales.fr › Composés chimiques organiques › Composés organométalliques › Composés organiques du mercure › Composés alkylés du mercure › Composés méthylés du mercure › The origin of methyl group in...
questionsmedicales.fr › Composés chimiques organiques › Hydrocarbures › Hydrocarbures acycliques › Alcanes › Méthane › The origin of methyl group in...
questionsmedicales.fr › Produits chimiques inorganiques › Métaux › Métaux lourds › Mercure › The origin of methyl group in...
questionsmedicales.fr › Archéobactéries › Euryarchaeota › Methanomicrobiales › Methanospirillum › The origin of methyl group in...
questionsmedicales.fr › Disciplines des sciences naturelles › Chimie › Biochimie › Protéomique › The origin of methyl group in...