Long noncoding RNA AK144717 exacerbates pathological cardiac hypertrophy through modulating the cellular distribution of HMGB1 and subsequent DNA damage response.
Animals
Cardiomegaly
/ genetics
RNA, Long Noncoding
/ genetics
HMGB1 Protein
/ metabolism
DNA Damage
Mice
Male
Mice, Inbred C57BL
Sirtuin 1
/ metabolism
Myocytes, Cardiac
/ metabolism
Ataxia Telangiectasia Mutated Proteins
/ metabolism
Angiotensin II
/ metabolism
Signal Transduction
Acetylation
Oxidative Stress
/ genetics
Cardiac hypertrophy
DNA damage response
HMGB1 acetylation
LncRNAs
Journal
Cellular and molecular life sciences : CMLS
ISSN: 1420-9071
Titre abrégé: Cell Mol Life Sci
Pays: Switzerland
ID NLM: 9705402
Informations de publication
Date de publication:
12 Oct 2024
12 Oct 2024
Historique:
received:
03
06
2024
accepted:
27
09
2024
revised:
09
09
2024
medline:
12
10
2024
pubmed:
12
10
2024
entrez:
12
10
2024
Statut:
epublish
Résumé
DNA damage induced by oxidative stress during cardiac hypertrophy activates the ataxia telangiectasia mutated (ATM)-mediated DNA damage response (DDR) signaling, in turn aggravating the pathological cardiomyocyte growth. This study aims to identify the functional associations of long noncoding RNA (lncRNAs) with cardiac hypertrophy and DDR. The altered ventricular lncRNAs in the mice between sham and transverse aortic constriction (TAC) group were identified by microarray analysis, and a novel lncRNA AK144717 was found to gradually upregulate during the development of pathological cardiac hypertrophy induced by TAC surgery or angiotensin II (Ang II) stimulation. Silencing AK144717 had a similar anti-hypertrophic effect to that of ATM inhibitor KU55933 and also suppressed the activated ATM-DDR signaling induced by hypertrophic stimuli. The involvement of AK144717 in DDR and cardiac hypertrophy was closely related to its interaction with HMGB1, as silencing HMGB1 abolished the effects of AK144717 knockdown. The binding of AK144717 to HMGB1 prevented the interaction between HMGB1 and SIRT1, contributing to the increased acetylation and then cytosolic translocation of HMGB1. Overall, our study highlights the role of AK144717 in the hypertrophic response by interacting with HMGB1 and regulating DDR, hinting that AK144717 is a promising therapeutic target for pathological cardiac growth.
Identifiants
pubmed: 39395058
doi: 10.1007/s00018-024-05464-0
pii: 10.1007/s00018-024-05464-0
doi:
Substances chimiques
RNA, Long Noncoding
0
HMGB1 Protein
0
Sirtuin 1
EC 3.5.1.-
Ataxia Telangiectasia Mutated Proteins
EC 2.7.11.1
Angiotensin II
11128-99-7
HMGB1 protein, mouse
0
Types de publication
Journal Article
Langues
eng
Sous-ensembles de citation
IM
Pagination
432Subventions
Organisme : National Natural Science Foundation of China
ID : No. 82370333, 82170321 and 81871113
Organisme : Natural Science Foundation of Jiangsu Province
ID : BK20201489
Organisme : Project 333 of Jiangsu Province
ID : 2022-2-408
Informations de copyright
© 2024. The Author(s).
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