The Immune Modulation
HLA
HLA-G
HLA-G*01:01:01
cancer
complotypes
gastric adenocarcinoma
haplotypes
immune modulation
non-classical HLA
tolerance
Journal
International journal of molecular sciences
ISSN: 1422-0067
Titre abrégé: Int J Mol Sci
Pays: Switzerland
ID NLM: 101092791
Informations de publication
Date de publication:
03 Oct 2024
03 Oct 2024
Historique:
received:
06
09
2024
revised:
25
09
2024
accepted:
28
09
2024
medline:
16
10
2024
pubmed:
16
10
2024
entrez:
16
10
2024
Statut:
epublish
Résumé
The Human Leukocyte Antigen (HLA) system contains a set of genes involved at many levels in the innate and adaptive immune response. Among the non-classical HLA class I genes, HLA-G stands out for the numerous studies about its pivotal role in regulating/modulating immune responses. Also, its involvement in extravillous cytotrophoblast function, viral infections, autoimmunity, and cancer has been extensively documented. The present study explores for the first time the relationship between natural alleles of HLA-G, rather than STSs, SNPs, or partial gene polymorphisms, and the development of gastric adenocarcinoma, by analyzing the genetic profile of a cohort of 40 Spanish patients with this type of tumor using DNA extracted from paired biopsies of tumoral and adjacent non-tumoral gastric tissue. Our results reveal a significant statistical relationship between the presence of the
Identifiants
pubmed: 39408976
pii: ijms251910645
doi: 10.3390/ijms251910645
pii:
doi:
Substances chimiques
HLA-G Antigens
0
Types de publication
Journal Article
Langues
eng
Sous-ensembles de citation
IM