Genetic architecture of routinely acquired blood tests in a British South Asian cohort.
Humans
Genome-Wide Association Study
Bangladesh
Female
Pakistan
Male
Glycated Hemoglobin
/ metabolism
Diabetes Mellitus, Type 2
/ genetics
Asian People
/ genetics
Adult
Ion Channels
/ genetics
United Kingdom
Middle Aged
Polymorphism, Single Nucleotide
Hematologic Tests
Cohort Studies
Alleles
Electronic Health Records
Blood Glucose
/ metabolism
Erythrocytes
/ metabolism
Journal
Nature communications
ISSN: 2041-1723
Titre abrégé: Nat Commun
Pays: England
ID NLM: 101528555
Informations de publication
Date de publication:
16 Oct 2024
16 Oct 2024
Historique:
received:
18
10
2023
accepted:
30
09
2024
medline:
17
10
2024
pubmed:
17
10
2024
entrez:
16
10
2024
Statut:
epublish
Résumé
Understanding the genetic basis of routinely-acquired blood tests can provide insights into several aspects of human physiology. We report a genome-wide association study of 42 quantitative blood test traits defined using Electronic Healthcare Records (EHRs) of ~50,000 British Bangladeshi and British Pakistani adults. We demonstrate a causal variant within the PIEZO1 locus which was associated with alterations in red cell traits and glycated haemoglobin. Conditional analysis and within-ancestry fine mapping confirmed that this signal is driven by a missense variant - chr16-88716656-G-T
Identifiants
pubmed: 39414775
doi: 10.1038/s41467-024-53091-x
pii: 10.1038/s41467-024-53091-x
doi:
Substances chimiques
Glycated Hemoglobin
0
Ion Channels
0
PIEZO1 protein, human
0
hemoglobin A1c protein, human
0
Blood Glucose
0
Types de publication
Journal Article
Langues
eng
Sous-ensembles de citation
IM
Pagination
8929Subventions
Organisme : RCUK | Medical Research Council (MRC)
ID : MR/V028766/1
Organisme : RCUK | Medical Research Council (MRC)
ID : M009017
Organisme : Wellcome Trust (Wellcome)
ID : WT102627
Investigateurs
Shaheen Akhtar
(S)
Mohammad Anwar
(M)
Elena Arciero
(E)
Omar Asgar
(O)
Samina Ashraf
(S)
Saeed Bidi
(S)
Gerome Breen
(G)
James Broster
(J)
Raymond Chung
(R)
David Collier
(D)
Charles J Curtis
(CJ)
Shabana Chaudhary
(S)
Megan Clinch
(M)
Grainne Colligan
(G)
Panos Deloukas
(P)
Ceri Durham
(C)
Faiza Durrani
(F)
Fabiola Eto
(F)
Sarah Finer
(S)
Joseph Gafton
(J)
Ana Angel Garcia
(AA)
Chris Griffiths
(C)
Joanne Harvey
(J)
Teng Heng
(T)
Sam Hodgson
(S)
Qin Qin Huang
(QQ)
Matt Hurles
(M)
Karen A Hunt
(KA)
Shapna Hussain
(S)
Kamrul Islam
(K)
Vivek Iyer
(V)
Ben Jacobs
(B)
Ahsan Khan
(A)
Cath Lavery
(C)
Sang Hyuck Lee
(SH)
Robin Lerner
(R)
Daniel MacArthur
(D)
Daniel Malawsky
(D)
Hilary Martin
(H)
Dan Mason
(D)
Rohini Mathur
(R)
Mohammed Bodrul Mazid
(MB)
John McDermott
(J)
Caroline Morton
(C)
Bill Newman
(B)
Elizabeth Owor
(E)
Asma Qureshi
(A)
Samiha Rahman
(S)
Shwetha Ramachandrappa
(S)
Mehru Reza
(M)
Jessry Russell
(J)
Nishat Safa
(N)
Miriam Samuel
(M)
Michael Simpson
(M)
John Solly
(J)
Marie Spreckley
(M)
Daniel Stow
(D)
Michael Taylor
(M)
Richard C Trembath
(RC)
Karen Tricker
(K)
Nasir Uddin
(N)
David A van Heel
(DA)
Klaudia Walter
(K)
Caroline Winckley
(C)
Suzanne Wood
(S)
John Wright
(J)
Julia Zollner
(J)
Informations de copyright
© 2024. The Author(s).
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